Research Opportunity Announcement (ROA): All of Us Center for Linkage and Acquisition of Data (CLAD)

The purpose of this Research Opportunity Announcement (ROA) is to solicit and review proposals, evaluate potential partners, and fund the future All of Us Center for Linkage and Acquisition of Data (CLAD). The intention of CLAD is to expand the type and research utility of program data by acquiring new passive data streams and providing additional methods to acquire data for existing data streams, such as electronic health records (EHRs). This ROA will include three phases. These phases aim to identify an offeror that has or can readily assemble a promising technology platform and services with capabilities to acquire and link passive data streams with existing All of Us participant data. The three phases include the following: Phase I � Submission and Evaluation of Full Technical and Cost Proposal Phase II � Data Linkage Platform (DLP) Capabilities Demonstration and Evaluation (Invitation Only) Phase III � Negotiation and OT Award (Invitation Only) The NIH intends to down-select at each phase, resulting in making one Other Transaction (OT) award in Phase III. For selected proposals invited to the next phase, further instructions will be provided to offerors at the conclusion of each phase. Award Project Duration: The period of performance anticipated for this OT award will be an 18-month base period, and may include up to four (4) twelve (12) month optional periods. Proposal Deadline: Proposals must be submitted by April 17, 2023 at 3 p.m. Eastern Time to be eligible for Phase I evaluation and potential invitation to subsequent phases of the CLAD competition. Letter of Intent: If you intend to submit a proposal in response to the CLAD ROA, please furnish the information requested in the Intent to Submit Proposal Form in the attachments for this posting and return by March 15, 2023 at 3pm ET. Although a letter of intent is not binding and does not enter into the review of a subsequent proposal, the information that it contains allows the All of Us Research Program to estimate the potential review workload and plan the review. Documents and Related Links: The full ROA package is attached in the 'Attachments/Links' section. Potential offerors are encouraged to carefully review the most recent updates to the announcement and attachments before submitting questions and/or preparing a proposal submission. A link to the All of Us Research Program webpage has been provided for additional information about our program. AMENDMENT 1 - The updates below are included in amendment 1. 1. Adds additional direction in CLAD ROA Section 8.1.2 - Proposal Format for font size in charts, tables, figures, and illustrations. 2. Revises direction in CLAD ROA Section 8.1.3 - Proposal Content #11 c, regarding the potential cost models to be proposed. 3. Adds attachment AOU_CLAD_ROA_OTA-23-003 FAQ -Amendment 1 dated 15 March 2023 4. Adds attachment AOU_CLAD_ROA_OTA-23-003 Informational Webinar 3 March 2023 AMENDMENT 2 - The updates below are included in Amendment 2: 1. Revises direction in CLAD ROA Section 8.1.2 Appendix A: Key Personnel, regarding NIH biosketch and resume requirements for Key Personnel proposed. 2. Add clarification in CLAD ROA Section 8.1.3 #10 Key Personnel that offerors must have at least a Principal Investigator or Program Director as key personnel. 3. Add attachment AOU_CLAD_ROA_OTA-23-003 FAQ -Amendment 2 dated 30 March 2023 4. Adds the link to the All of Us Funding Opportunity webpage that contains the Research Opportunity Announcement (ROA): All of Us Center for Linkage and Acquisition of Data No. OTA-23-003 pre-submission webinar, held March 3, 2023. AMENDMENT 3 - The updates below are included in Amendment 3: 1. Adds attachment AOU_CLAD_ROA_OTA-23-003 FAQ Set 2_7April 2023 2. Adds revised attachment AOU_CLAD_ROA-OTA-23-003 Appendix F-Cost Proposal Breakdown 7 APR 2023