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490 BIOTECH INC

UEI: L2T9XGZ1JUL5

490 BIOTECH INC is a federal contractor, registered under UEI L2T9XGZ1JUL5. It has been awarded $5,486,737 in federal contracts. Primary work spans Unknown NAICS. Top awarding agencies include Department Of Health And Human Services, National Aeronautics And Space Administration (nasa), and National Science Foundation.

Contact Information

Registration and classification details

Registration

UEI Code

L2T9XGZ1JUL5

Federal Contracting Overview

Award totals, agency breakdown, NAICS distribution, and geographic footprint.

AI Capability Profile

490 BIOTECH INC specializes in the development of advanced bioluminescent reporters and high-throughput screening technologies for biomedical research. Their core capabilities include the engineering of synthetic luciferase/luciferin genetic pathways and the expression of humanized bacterial lucifer...

Key Performance Metrics

Awards Count

12

All time

Active

0

Currently performing

Completed

12

Past period of performance

Total Awards

All time

Contracts

Prime · all time

Subcontracts

Sub · all time

Grants

Prime · all time

Subgrants

Sub · all time

Award Analytics & Distribution

Awards by Agency

Department Of Health And Human Services$4.8M87.2%National Aeronautics And Space Administration (nasa)$453.4K8.3%National Science Foundation$150.0K2.7%Department Of Agriculture$99.6K1.8%

Awards by NAICS

Awards by Agency Over Time

Awards by Place of Performance

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AI-Assisted Chatbot and TA Knowledge Base DevelopmentThis subcontract opportunity with the Department of Health and Human Services focuses on the development and implementation of a curated knowledge repository and an AI-driven interface for prime contractors working on Administration for Community Living projects. The selected provider will be responsible for building a searchable Technical Assistance Knowledge Base and deploying an AI-assisted chatbot designed to automate the delivery of authoritative guidance. The project requires specialized expertise in AI/ML development and Knowledge Management architecture to ensure the successful delivery of a functional chatbot and a comprehensive knowledge base. Performance for this contract will take place in Rockville, Maryland, with a response deadline set for November 3, 2026.

Department Of Health And Human Services

POSTED

DEADLINE

in about 17 hours

UCEDD Core Functions Dashboard DevelopmentThis subcontract involves the development and maintenance of a public-facing performance visibility tool for prime contractors working on projects for the Department of Health and Human Services Administration for Community Living. The primary objectives include the design of a Core Functions Dashboard and a web-based Program Progress Report submission system to ensure efficient tracking and reporting of project milestones. The project requires strict adherence to Section 508 accessibility compliance and HHS Information Security Program standards to ensure data security and inclusivity. Performance will take place in Rockville, Maryland, under NAICS code 541511, with the ultimate goal of delivering a fully functional dashboard and a sustainably maintained reporting system.

Department Of Health And Human Services

POSTED

DEADLINE

in about 17 hours

I/DD Program Development and Technical Assistance (TA)The I/DD Program Development and Technical Assistance subcontract supports prime contractors on projects for the Department of Health and Human Services Administration for Community Living. The scope of work focuses on network-wide training, capacity-building, and intensive community-driven technical assistance designed to facilitate problem solving for individuals with intellectual and developmental disabilities and their families. Key deliverables include the development of Community Impact Blueprints, Strategic TA Plans, and community-driven outcome reports. Execution of this contract requires deep subject matter expertise in the DD Act of 2000. The performance location is based in Rockville, Maryland, under NAICS code 541618. Interested parties should note the response deadline of November 3, 2026.

Department Of Health And Human Services

POSTED

DEADLINE

in about 17 hours

University Centers for Excellence in Developmental Disabilities Education, Research and Service Community Impact and Capacity Building Initiative: Technical Assistance to Strengthen Outcomes for People with I/DD and Their Families

Solicitation # UCEDD

The Department of Health and Human Services, through the Administration for Community Living and the Administration on Disabilities, has issued a Request for Information to conduct market research for a contract providing network-wide training, technical assistance, and capacity-building support to University Centers for Excellence in Developmental Disabilities Education, Research and Service. The primary objective is to strengthen outcomes for people with intellectual and developmental disabilities and their families in accordance with the Developmental Disabilities Assistance and Bill of Rights Act of 2000. The contemplated scope includes the development of Community Impact Blueprints to scale promising approaches, the creation of a Strategic TA Plan to establish annual levels of effort, and the implementation of technology solutions such as a Core Functions Dashboard and an AI-assisted chatbot. The government is seeking industry feedback on the feasibility of the draft Performance Work Statement, recommended staffing models, and rough order of magnitude cost estimates. Preliminary classification is under NAICS 541611 for Administrative Management and General Management Consulting Services. The anticipated contract structure consists of a base year and four option years, requiring strict adherence to HHS Information Security Program standards and Section 508 accessibility requirements. Interested respondents must submit their capabilities and recommendations by November 3, 2026.

Department Of Health And Human Services

POSTED

DEADLINE

in about 17 hours

Repatriation Case Management and Financial Support Services

Solicitation # 47QTCA25D007Q-7571MN26F80127

This special notice announces the transfer of a contract for Repatriation Case Management and Financial Support Services from the Department of the Interior to the Department of Health and Human Services. Originally awarded to Respones AI, LLC on September 24, 2025, as contract number 47QTCA25D007Q - 140D0425F1000, the agreement transitioned to the new contract number 47QTCA25D007Q - 7571MN26F80127 effective September 29, 2026. The transfer maintains all original terms and conditions, specifically preserving the ultimate contract value and the period of performance. This project is designated as a total small business set-aside under NAICS code 541519, with the place of performance located in Virginia.

Department Of Health And Human Services

POSTED

about 1 month ago

DEADLINE

OHS Region 11 Training and Technical Assistance Network

Solicitation # 7571MN26C00013

The Department of the Interior’s existing contract with ICF Incorporated, LLC, numbered 140D0425C0027, has been administratively transferred to the Department of Health and Human Services under a new task order, 7571MN26C00013, effective July 1, 2026. This transfer is purely administrative and does not alter the original contract’s scope of work, deliverables, ultimate value, or period of performance. The work continues under the same terms and conditions, now managed by HHS to support the OHS Region 11 Training and Technical Assistance Network, with performance based in Reston, Virginia, and administrative oversight from Washington, DC. The contract, classified under NAICS code 541611, remains unrestricted with no set-aside requirements and is fully maintained under the original contractor’s responsibility. Point of contact for inquiries includes Carla Carter and Hamed Hassanzadeh Makou at HHS.

Department Of Health And Human Services

POSTED

DEADLINE

Portfolio Management System (OPS)

Solicitation # 7571MN26F80053

The Department of the Interior’s contract GS35F523BA/140D0422F0466, originally awarded to the Community Development Institute on May 11, 2022, for the Portfolio Management System (OPS), has been administratively transferred to the Department of Health and Human Services under the new contract number GS35F523BA/7571MN26F80053, effective June 12, 2026. This transfer does not modify any existing terms, including the ultimate contract value or the period of performance, and all scope of work, deliverables, and contractual obligations remain unchanged. The contract, identified by NAICS code 541511, is managed by HHS with the primary point of contact being Amber Harris at [email hidden], and the work is performed in Madison, Wisconsin, while the contracting office is located in Washington, D.C. The contract notice was posted on June 15, 2026, and the change is purely administrative, with no impact on the contractor or the execution of the project.

Department Of Health And Human Services

POSTED

DEADLINE

Clinical Research Organization (CRO)This subcontract opportunity with the Department of Health and Human Services is for a Clinical Research Organization to manage and execute clinical trials for small businesses on NIH STTR projects. The selected provider will be responsible for patient recruitment, trial monitoring, clinical data management, and regulatory submission support, utilizing specialized management software and medical monitoring equipment. All operations must maintain strict FDA compliance and obtain necessary IRB approvals to deliver comprehensive clinical trial reports, patient outcome data, and regulatory filings. The procurement is designated as a Total Small Business Set-Aside under the SBIR/STTR mandate for companies with fewer than 500 employees, falling under NAICS code 541715. The solicitation was posted on May 28, 2026, with a response deadline of April 6, 2027.

Department of Health and Human Services

POSTED

DEADLINE

Specialized Scientific/Technical ConsultantThis subcontract opportunity with the Department of Health and Human Services seeks a Specialized Scientific/Technical Consultant to provide niche technical services for small businesses on NIH STTR projects. The scope of work includes performing specialized assays, toxicity testing, laboratory tests, data analysis, and the fabrication of specialized components using high-precision instrumentation and specific chemical or biological reagents. Deliverables consist of test results, analyzed data sets, or fabricated prototype components, with a requirement for GLP or GMP certifications if clinical trials are involved. The contract is a total small business set-aside under the SBIR/STTR mandate for firms with fewer than 500 employees, falling under NAICS code 541715. It was posted on May 28, 2026, with a response deadline of April 6, 2027.

Department of Health and Human Services

POSTED

DEADLINE

Non-Profit Research Institution PartnerThis subcontract opportunity with the Department of Health and Human Services seeks a recognized non-profit research institution to partner with small business concerns on NIH STTR projects. The selected partner will be responsible for establishing technical merit, conducting feasibility studies, and executing full-scale research, development, and prototype creation. To fulfill these requirements, the institution must provide access to specialized medical and scientific equipment, laboratory facilities, and academic research archives. The project requires the delivery of validated prototypes, comprehensive technical reports, research data, and peer-reviewed publications. This is a total small business set-aside under the SBIR/STTR mandate for organizations with fewer than 500 employees, falling under NAICS code 541715. The response deadline for this opportunity is April 6, 2027.

Department of Health and Human Services

POSTED

DEADLINE

Clinical Research Coordination and EnrollmentThis subcontract for Clinical Research Coordination and Enrollment supports prime contractors on clinical trials for the NIH, CDC, and FDA. The scope of work involves participant recruitment, enrollment, and administrative management using electronic medical records, Electronic Data Capture systems, and practice-based research networks. All activities must adhere to GCP standards, HIPAA compliance, and require IRB approval to deliver patient cohorts and clinical trial data reports. The opportunity is issued by the Department of Health and Human Services under NAICS code 541715. It is designated as a Total Small Business Set-Aside for firms with fewer than 500 employees. The solicitation was posted on May 28, 2026, with a response deadline of April 6, 2027.

Department of Health and Human Services

POSTED

DEADLINE

Commercial Product PrototypingThis subcontract opportunity with the Department of Health and Human Services focuses on the supply and manufacture of early stage prototypes and proof of concept hardware for prime contractors working on NIH, CDC, and FDA research and development projects. The scope of work includes rapid prototyping, 3D printing, CNC machining, and PCB design, specifically utilizing biocompatible materials and medical grade plastics to deliver functional models of commercial products. The contract is designated as a total small business set aside under NAICS code 339113, requiring firms to have fewer than 500 employees. A critical requirement for eligibility is ISO 13485 certification for medical devices. Interested parties must submit their responses by April 6, 2027.

Department of Health and Human Services

POSTED

DEADLINE

R&D Laboratory Testing and AnalysisThis subcontract opportunity with the Department of Health and Human Services focuses on providing specialized scientific testing, assays, and laboratory analysis to support prime contractors on R&D projects for the NIH, CDC, and FDA. The scope of work includes conducting feasibility studies, biological or chemical analysis, sample testing, and data validation utilizing mass spectrometers, bio-analytical tools, and high-throughput screening equipment. All work must adhere to GLP or ISO/IEC 17025 standards, with the final deliverables consisting of validated data sets and technical reports. The project is categorized under NAICS code 541715 and is designated as a Total Small Business Set-Aside, specifically adhering to SBIR/STTR mandates for companies with fewer than 500 employees. The solicitation was posted on May 28, 2026, and the deadline for responses is April 6, 2027.

Department of Health and Human Services

POSTED

DEADLINE

FDA/NIH Regulatory Affairs ConsultingThis subcontract opportunity with the Department of Health and Human Services focuses on providing expert regulatory affairs consulting for prime contractors working on innovation projects for the NIH, CDC, and FDA. The selected provider will be responsible for developing regulatory strategies, creating compliance roadmaps, and preparing critical documentation, including 510(k) submissions, PMA applications, and Investigational Device Exemptions using specialized submission software. A deep expertise in FDA CFR is required to ensure all delivery packages meet strict federal standards. The contract is designated as a total small business set-aside under NAICS code 541611, specifically catering to firms with fewer than 500 employees in alignment with SBIR/STTR mandates. Interested parties must submit their responses by April 6, 2027, following the posting date of May 28, 2026.

Department of Health and Human Services

POSTED

DEADLINE

Intellectual Property (IP) Strategy ConsultingThis subcontract for Intellectual Property Strategy Consulting supports prime contractors receiving NIH SBIR/STTR grants through the Department of Health and Human Services. The selected provider must be a licensed Patent Attorney or IP Strategist capable of performing IP audits, developing protection strategies, and conducting patent landscape analyses. Key deliverables include the drafting and filing of patent applications, the execution of freedom-to-operate searches, and the comprehensive management of IP portfolios, culminating in a formal IP Strategy Report. The opportunity is designated as a Total Small Business Set-Aside under NAICS code 541110, requiring the contractor to have fewer than 500 employees. The solicitation was posted on May 28, 2026, with a response deadline of April 6, 2027.

Department of Health and Human Services

POSTED

DEADLINE

Regulatory Strategy and Submission ConsultingThis subcontract for Regulatory Strategy and Submission Consulting supports prime contractors receiving NIH SBIR/STTR grants by providing expert regulatory analysis and submission preparation. The scope of work includes developing regulatory strategies, managing clinical trial filings, and preparing 510(k) or PMA submissions to ensure full compliance with FDA and EMA standards. The selected provider must possess deep expertise in medical device and drug approval pathways to deliver a formal regulatory roadmap and completed submission packages. The opportunity is issued by the Department of Health and Human Services and is designated as a Total Small Business Set-Aside for firms with fewer than 500 employees. It falls under NAICS code 541611, with a response deadline of April 6, 2027.

Department of Health and Human Services

POSTED

DEADLINE

Independent R&D Replication/Confirmation ServicesThis subcontract opportunity with the Department of Health and Human Services involves providing independent R&D replication and confirmation services for prime contractors receiving NIH SBIR/STTR grants. The selected provider will be responsible for conducting independent replication studies and validation tests to confirm research findings and prove technical efficacy, ultimately delivering a formal Validation Report or Independent Study Results. The contract is a total small business set-aside under NAICS code 541715, requiring the provider to have fewer than 500 employees. Eligible candidates must possess CRO status or operate within CLIA/CAP accredited laboratory facilities. The solicitation was posted on May 28, 2026, with a response deadline of April 6, 2027.

Department of Health and Human Services

POSTED

DEADLINE

Market Research and Commercialization AnalysisThis subcontract opportunity with the Department of Health and Human Services focuses on providing third-party market analysis and commercialization strategies for prime contractors receiving NIH SBIR/STTR grants. The selected provider will be responsible for identifying target customers, analyzing competitive positioning, conducting customer interviews, and defining TAM, SAM, and SOM market sizes. The final deliverables include a comprehensive Market Research Report and a detailed Commercialization Plan. Eligible candidates must possess specialized experience in the biotech, med-tech, or healthcare sectors. This is a Total Small Business Set-Aside under NAICS code 541613, requiring the contractor to have fewer than 500 employees. The solicitation was posted on May 28, 2026, with a response deadline of April 6, 2027.

Department of Health and Human Services

POSTED

DEADLINE