​Mitigating Proliferation Risks Posed by Artificial Intelligence Enabled Molecular Models and Leveraging Nonproliferation Opportunities​

The Department of State’s Bureau of Arms Control and Nonproliferation is seeking proposals through solicitation DFOP0018449 to address emerging proliferation risks posed by artificial intelligence-enabled molecular models, with the goal of developing safeguards, tools, and international frameworks to prevent the misuse of such technologies for chemical and biological weapons purposes. This funding opportunity is open to domestic and international non-profits, educational institutions, and for-profit organizations, which must demonstrate the ability to identify key stakeholders in AI-driven molecular design, assess technical vulnerabilities in training data and infrastructure, and develop actionable mitigation measures including secure platforms, ethical guidelines, and capacity-building initiatives such as workshops, table-top exercises, and mentorship programs. All proposals must align with the stated program objectives, include a detailed project narrative not exceeding ten pages, and adhere to strict formatting guidelines including English language, 12-point Times New Roman font, single-spacing, and 8.5 x 11 paper size. Applicants are required to submit standardized federal forms including SF-424 and SF-424A, a detailed line-item budget using the provided template, and consolidated resumes or position descriptions for key personnel, with all financial figures stated in U.S. dollars. Proposals must be submitted via Grants.gov and MyGrants by the deadline of July 21, 2026, and are subject to a two-stage evaluation process: a mandatory technical eligibility review screening for compliance with all required documentation and eligibility criteria, followed by a merit review conducted by a panel assessing proposed activities, organizational capability, and budget realism—all scored on a 100-point scale. Successful applicants must maintain an active UEI and SAM.gov registration throughout the award period and comply with a wide array of federal regulations including 2 CFR parts 200, 170, 175, 182, 183, and 600, as well as Executive Orders regarding free speech, drug-free workplaces, and prohibitions against contracting with enemies. Foreign assistance exceeding $500,000 requires a Trafficking in Persons compliance plan and certification. Awards are limited to a maximum period of performance of 24 months, with quarterly narrative and financial reporting mandated via MyGrants, including an M&E tracker comparing targets and results. Final reports are due within 120 days of award expiration and must include sustainability plans, lessons learned, and supporting documentation. Payment will be processed through the HHS Payment Management System,