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This Sources Sought opportunity was posted on August 9, 2017. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

Biomarker Study

Awarded
W81XWH17T0394Federal

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The Biomarker Study, solicitation number W81XWH17T0394, requires the delivery of a detailed report analyzing 22 confounding issues for 350 study participants, including both PTSD cases and controls. The objective is to determine if selected biomarker panels can accurately identify PTSD despite the presence of variables such as specific medications, depression, co-morbidities, or alcoholism. This data is essential for testing current molecular indicators and exploring the stratification of PTSD into subtypes to enable more personalized therapeutic strategies. To complete this report, a comprehensive review of participant files is necessary, including oral psychiatric interviews and various self-report tools such as the Beck Depression Index, the Pittsburgh Sleep Quality Index, and the Symptoms Checklist-90. The work is performed in support of the consortium for Systems Biology of PTSD and is based at Fort Detrick, Maryland.

General Info

Agency

N/A

Contract Value

$525,000

NAICS

541380 - Testing Laboratories and Services

Place of Performance

Fort Detrick, MD, 21702, USA

Set-Aside

NONE

Award Issued Date

Documents

0

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Timeline

PhaseAwarded
Posted

Sources Sought

Awarded

Contract was awarded

Submission Closed

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Organization & Contact Information

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AgencyN/A
Contacts1 person available
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Office AddressN/A
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Full Description

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Provide a report of 22 confounding issues for each participant, showing the ID numbers of the PTSD cases and controls for the entire set of persons participating the study (350 total). Twenty-two confounding issues have been listed to date. Therefore, 22 individual sets of information will need to be determined from each of the 350 persons. This information is critical to be able to determine if the panels of biomarkers USACEHR has selected continue to identify PTSD if the individual are taking specific medicines, if they are being treated for depression or other co-morbidities, in the presence of alcoholism, etc. Additionally, USACEHR is asking whether some of the confounding factors (such as inflammatory markers) to separate subgroups of individuals. Such stratification into subtypes of PTSD will enable us to obtain a better success rate for the identification of persons with PTSD and have potential to provide a - personalized approach for therapeutic strategies. For the past 5 years, the consortium for Systems Biology of PTSD, has collaborated to carry out studies to determine a panel of measurements which will objectively identify PTSD. This report is urgently needed in order to test the current panels of molecular indicators. It will involve going through each file of the 350 persons in these various cohorts to determine which of the 22 overarching confounders is/is not present. The records which will be searched include notes from the oral psychiatric interview, each of the self-report tests addressing depression (Beck Depression Index), sleep quality (Pittsburgh sleep quality index), general symptoms (Symptoms checklist -90) and some 6 other detailed information report tools which form a basis of the analysis.

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