This Solicitation opportunity from Government of Canada was posted on January 25, 2023. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Correction of AECL doses in the NDR, and Mortality and Cancer Incidence Analysis of Canadian NEWs

Closed

1000245949International

Submission Closed02/08/2023, 02:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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about 16 hours ago

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in almost 2 years

AI Contract Overview

This contract, managed by Health Canada in partnership with the Canadian Nuclear Safety Commission, focuses on validating the National Dose Registry database and analyzing the health outcomes of Canadian nuclear energy workers. The contractor is tasked with reviewing Atomic Energy of Canada Limited source files to identify and correct dose discrepancies within the registry. This phase includes replicating a 1993 analysis to assess how dose corrections impact risk estimates, followed by the production of a peer-reviewed report detailing the verification and correction process. Additionally, the contractor will develop and execute a scientific proposal to analyze mortality from 1950 to 2018 and cancer incidence from 1969 to 2018. This involves comparing cohort rates against the general Canadian population and conducting detailed statistical analyses on the effects of low-LET ionizing radiation and tritium internal doses. The project concludes with the delivery of a final peer-reviewed report and the preparation of a manuscript for scientific publication.

General Info

Contract to validate dose registry and analyze health outcomes for Canadian nuclear workers.

Agency

Government of Canada → Health Canada

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

*National Capital Region (NCR), CAN

Set-Aside

NONE

Documents

pr1000245949_acan_english.docx

AI Contract Breakdown

Uniform Contract Format

Contract not broken down yet

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Timeline

PhaseClosed

PostedJan 25

Solicitation

Response DeadlineFeb 8

Deadline has passed

Submission Closed

02/08/2023, 02:00:00 PM UTC

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Organization & Contact Information

AgencyGovernment of Canada → Health Canada

Contacts1 person available

OfficeN/A

Organization / AgencyGovernment of Canada → Health Canada

Office AddressN/A

Contacts

Phillips WesleyPoint of Contact

contact@example.gov

+1 (555) 000-0000

Full Description

The over-arching objectives are to validate that the National Dose Registry (NDR) database contains all the best available data for Atomic Energy of Canada Limited (AECL) workers, and then to use the whole NDR dataset, linked to mortality (1950–2018) and cancer incidence (1969–2018), to characterize the dose-response relationship between occupational exposure to ionizing radiation and health outcomes. The contractor will:a. Review and compare the characteristics and doses of the different AECL source files to the NDR. Identify all discrepancies and recommend and document corrective measures. Review and describe characteristics of AECL links and non-links to the NDR. Create a corrected AECL file, through discussions with HC and the Canadian Nuclear Safety Commission (CNSC).b. Replicate and compare an analysis published by AECL in 1993 (Gribbin, Weeks et al. 1993) using the corrected AECL file and mortality follow-up to 1990. Compare risk estimates with the Gribbin study and assess the impact of the dose corrections on risk estimates and the impact of links/non-links to the NDR.c. Meet with CNSC and HC staff to discuss the dose discrepancies and seek consensus on any recommended additions/corrections to doses to the NDR. HC will make the agreed additions/corrections in the NDR.d. Prepare a report, which includes the background, methods, results, discussion, conclusions, and recommendations of the verification and correction of AECL doses (a.), dose-response analysis (b.) and addition of early AECL doses in the NDR (c.). The report will be internally and externally peer reviewed. HC and CNSC staff will arrange the peer reviews and contractor will prepare disposition report in response to peer reviewers.In partnership with Health Canada (HC) and the Canadian Nuclear Safety Commission (CNSC), the contractor will also:e. Prepare a scientific proposal for an updated mortality (1950–2018) and cancer incidence (1969–2018) analysis of the NDR’s Canadian nuclear energy workers (i.e., background, objectives, proposed analysis strategy, proposed methods, timetable, deliverables, and budget).f. Participate in activities (i.e., prepare applications, support presentations, revise proposal) to obtain approvals (i.e., PHAC/HC Research Ethics Board approval, Statistics Canada Microdata Access Agreement) for this project.g. Conduct a detailed statistical analysis as outlined in the scientific proposal. This must include the following:Comparison of the rates of all causes of mortality and all causes of cancer incidence of the cohort with those for the sex- age- and calendar-specific rates for the general Canadian population (SMR and SIR).h. Detailed internal scientific analysis of the cancer mortality (1950–2018) and cancer incidence (1969–2018) among the NDR’s Canadian nuclear energy workers cohort with respect to the following:Whole-body doses of low-LET ionizing radiation (internal comparisons, dose response relationships, modifying effects, confounding, etc.).Internal doses from tritium (internal comparisons, dose response relationships, modifying effects, confounding, etc.).i. Prepare a detailed draft report (introduction, methods, results, discussion, and conclusion) for external peer review. HC/CNSC staff will arrange the external peer review.j. Prepare a final report, which dispositions/addresses the peer review comments.k. Prepare manuscript (in partnership with HC/CNSC staff) for publication.