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Emergency Permit for Management of Hazardous Waste, RAPT Therapeutics, Inc., South San Francisco, California

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The California Department of Toxic Substances Control has issued an emergency permit to RAPT Therapeutics, Inc. in South San Francisco to safely stabilize a highly hazardous quantity of 1-Hydroxybenzotriazole, a shock- and friction-sensitive explosive powder stored at their facility. Due to the extreme risk of detonation from even minor disturbances, the permit authorizes controlled chemical treatment using remote equipment to open the container and dilute the substance with deionized water into 1-gallon containers at a 1% concentration, reducing its explosive potential prior to transportation. This stabilization work must be performed by Triumvirate Environmental, LLC using specialized remote-handling tools to ensure operator safety, with approximately 40 grams of the chemical diluted per gallon of water. The stabilized waste will then be transferred to a DOT-compliant trailer for transport to an authorized hazardous waste disposal facility. The emergency permit is effective from June 29, 2026, through August 27, 2026, and requires RAPT Therapeutics to submit a certified final report within ten business days after expiration, confirming complete removal of all residual hazardous material and proper management of all waste generated during the stabilization process. The action is mandated under Title 22, CCR, Section 66270.61, to mitigate an imminent and substantial threat to public safety and the environment posed by the unstable chemical. The permit reflects a direct response to the hazardous properties of the substance and the critical need to prevent accidental detonation during storage or transport, with oversight and coordination managed by DTSC and designated contractors to ensure compliance with state hazardous waste regulations.

General Info

DTSC authorizes remote stabilization of explosive 1-Hydroxybenzotriazole using diluted water, safe transport, and certified waste removal by Triumvirate.

Agency

California Toxic Substances Control, Department of

NAICS

562211 - Hazardous Waste Treatment and DisposalView NAICS

Place of Performance

South San Francisco, CA, 94080

Set-Aside

NONE

Documents

(1)

Emergency Permit for Hazardous Waste Management - RAPT Therapeutics

PDFemergency-permit

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Organization & Contact Information

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AgencyCalifornia Toxic Substances Control, Department of
Contacts3 people available
OfficeN/A
Organization / Agency
California Toxic Substances Control, Department of
Office AddressN/A
Contacts
Lung-Yin TaiHazardous Substances Engineer
Colin DowdWaste Approvals Specialist
Matt HernanSenior Facilities Manager

Full Description

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The California Department of Toxic Substances Control (DTSC), pursuant to authority granted under California Code of Regulations (CCR), Title 22, Division 4.5, Chapter 20, Sec. 66270.61, has issued an Emergency Permit to the RAPT Therapeutics, Inc., (EPA ID# CAR000254631) to treat hazardous waste through a controlled reaction with chemical solutions/open detonation; transfer and storage of Resource Conservation and Recovery Act (RCRA) hazardous waste to a trailer that meets the the Department of Transportation’s (DOT) flammable specifications and transport the hazardous waste to the final disposition facility. Specifically, one (1) 100-gram container of 1-Hydroxybenzotriazole must be stabilized prior to transport to an authorized hazardous waste treatment, storage, and disposal facility. This chemical is currently being stored at RAPT Therapeutics, Inc. located at 561 Eccles Avenue, South San Francisco, California. DTSC has determined as a safety precaution to prevent an accident or severe injury, an Emergency Permit should be issued for treatment of chemicals to chemically stabilize the hazardous wastes prior to storage and eventual transportation off-site by Triumvirate Environmental, LLC. (TEI). Background: 1-Hydroxybenzotriazole is a white crystalline powder with lumps and is a primary explosive that is shock-sensitive and friction-sensitive. Due to the potential explosivity and the sensitivity to shock and friction, DTSC considers this chemical to be an imminent and substantial endangerment to human health and the environment. Chemical stabilization is recommended prior to transport to a permitted treatment, storage, and disposal facility. Project Activities: Because friction and disturbance caused by removing a container cap can potentially trigger the detonation or deflagration of some shock-sensitive chemicals, the TEI’s High Hazard Technician will utilize specially designed remote opening equipment to access the containers from a safe distance. Once the bottle has been remotely opened, the 1-Hydroxobenzotriazole will be diluted with deionized water into 1-gallon containers to achieve 1% dilutions. There will be ~40 grams per 1 gallon of water. Within 10 business days of the expiration of this permit, RAPT Therapeutics, Inc. will submit a final report, signed in accordance with Title 22, CCR Sec. 66270.11(d). The report shall include certification that the treatment area has been cleared of all residual hazardous waste generated from this emergency treatment and all generated waste has been properly managed. The Emergency Permit is effective beginning June 29, 2026 and shall expire on August 27, 2026.

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