Forecast to Publish a Notice of Funding Opportunity (NOFO) for NCI Community Oncology Research Program (NCORP) Academic Community Sites (UG1 Clinical Trials Not Allowed)
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The National Institutes of Health, through the National Cancer Institute, is issuing Notice of Funding Opportunity RFA-CA-27-008 to establish NCORP Academic Community Sites. These sites are defined as consortia comprising academic medical centers, public hospitals, and community oncology practices designed to improve the generalizability of clinical trial results by engaging diverse patient populations in research focused on cancer control, prevention, treatment, and care delivery. Under these UG1 cooperative agreements, clinical trials are not allowed, but the sites must provide the infrastructure to support participant accrual and collaborate with NCORP Research Bases to identify care disparities and provide input on protocol feasibility. Academic Community Sites are required to meet or exceed an annual accrual of 70 new unique participants, evenly split between cancer control, prevention, and screening or post-treatment surveillance trials, and treatment and imaging trials. Participation in cancer care delivery studies is optional, though those opting in must maintain at least three open protocols per year. This solicitation, associated with NAICS code 622310, has an application deadline of September 18, 2026, and is managed by the National Cancer Institute to ensure a representative participant pool for rigorous cancer research.
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Full Description
This Notice of Funding Opportunity (NOFO) is one of three NOFOs for the National Cancer Institute (NCI) Community Oncology Research Program (NCORP). NCORP is designed to enhance generalizability and dissemination of clinical trial results through accrual in a variety of community settings. The purpose of NCORP is to engage cancer patient populations, those at risk of cancer, and organizations in rigorous studies focused on cancer control, prevention, treatment and care delivery.
NCORP will support the following components that will be individually awarded through the respective Request for Applications (RFAs) indicated below:
- NCORP Research Bases (UG1 Clinical Trials Required);
- NCORP Community Sites (UG1 Clinical Trials Not Allowed); and
- NCORP Academic Community Sites (UG1 Clinical Trials Not Allowed)
NCORP Academic Community Sites are consortia of community hospitals and/or oncology practices, a public hospital, and an academic medical center that serves a patient population that can enhance the representativeness of participants accrued to cancer control, prevention, treatment and care delivery clinical trials and other human subjects research. The academic medical center should have robust infrastructure to support accrual of participants across their affiliate organizations.
NCORP Academic Community Sites are expected to meet or exceed the required annual 70 new unique patient/participant accruals evenly distributed between cancer control, prevention, and screening/post-treatment surveillance trials, and treatment and imaging trials, respectively. Participation in cancer care delivery studies will be optional. For those who propose cancer care delivery participation, NCORP Academic Community Sites must meet or exceed the required minimum of 3 cancer care delivery protocols open per year. NCORP Academic Community Sites interact with the NCORP Research Bases by: 1) providing insight into clinical significance during concept development; 2) identifying care disparities in their local populations that could be studied; and 3) providing input on feasibility during protocol development.
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