Full-Service Bioinformatics Pipeline Analysis

This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NICHD-20-261 and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2020-08. The North American Industry Classification (NAICS) Code is 541380 and the business size standard is $16.5m. However, this solicitation is not set aside for small business. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intend to procure on a sole source basis with Zymo Research Corporation of Irvine, CA to provide Full-Service Bioinformatics Pipeline Analysis Service: Service to include: Methyl-MaxiSeq - Full-Service Bioinformatics Pipeline Analysis for quantity of twenty Human DNA samples: 1. Raw data alignment, methylation calling, and genome browser tracks (methylation tracks as well as read tracks) 2. Statistical comparisons including results tables listing the most differentially methylated cytosines along with the corresponding annotation of chromosomal locations, gene names, promoter regions, & CpG islands 3. Genomic region coverage charts 4. Genome-wide read coverage plots 5. Violin plots 6. Clustering heatmaps 7. Spike-in controls for data validation 8. New work/data will be used to compare and pool with previous results that Zymo and NIH has already from previous wok for ongoing project. This is an ongoing project that Zymo already has provided previous samples from last year. This project is to increase the total sample size. The previous data, relative to the 30 samples we already have, were provided by Zymo and were used for analysis by the NICHD bioinformatics group. Methylation analysis is a very sensitive method and different companies can use different reagents and/or different machines that will produce subtle, but important, differences, preventing the expansion of the sample size by joining the previously obtained data since the data will not be compatible. So, we cannot change the company at this point to ensure the proper integrity of all our data and be sure to be able to compare and pool all previous results with this new data. Changing the company, at this point, will prevent the correct interpretation in the ongoing experiment. The proposed contract action is for supplies or services for which the Government intends to solicit and negotiate with only one source under authority of the 41 U.S.C. 253(c) (1), FAR 6.302. Only one responsible source and no other supplies or services will satisfy agency requirements. The offeror must include a completed copy of the provision of FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items with its offer. The provisions of FAR Clause 52.212-1 Instructions to Offerors - Commercial Items; FAR Clause 52.212-2, Evaluation - Commercial Items; FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions applies to this acquisition. NOTE TO CONTRACTOR: The contractor shall provide a completed copy of FAR 52.204-24, "Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment" with their quote in response to this solicitation. The offeror must include their Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. The clauses are available in full text at http://www.acquisition.gov/far/. Responses to this solicitation must include sufficient information to establish the interested parties bona-fide capabilities of providing all services listed. Vendors capable of furnishing the government with the services and or items specified in this synopsis should submit a copy of their quotation/offer to the following email address: contact@example.gov Attn: Tina Robinson by the due date and time below. Offers must also be accompanied by descriptive literature, warranties and/or other information that demonstrates that the offer meets all the foregoing requirements. Offeror must include the delivery date/timeframe with offer. Quotations will be due seven calendar days from the publication date of this synopsis before August 31, 2020 before 5:00 pm EST. The quotation must reference - Solicitation number NICHD-20-261 and - Solicitation number NICHD-20-261 must be on/in subject line of email. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Any questions must be sent via email to contact@example.gov and must include Solicitation# NICHD-20-261 in the subject line of email. Note: In order to receive an award, contractor must be registered as all awards and have valid certification in the System for Award Management (SAM) @ www.Sam.gov. Lack of valid registration in SAM will make an offeror ineligible for award.