Gene Deficient Mice

This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6, simplified acquisition procedures and the resultant purchase order will include all applicable provisions and clauses in effect through the Federal Acquisition Circular 05-40. This announcement constitutes the only 100% total small business set aside solicitation. This synopsis, NAICS code 541711, is to notify contractors that the government intends to issue a Firm Fixed Price Purchase Order in accordance with FAR Part 13.106 for the following statement of work, under the simplified acquisition procedures. Any firm that believes it is capable of providing the required service as stated herein may submit a capability statement to document its ability to provide the required services. A determination to compete this procurement based on a response to this notice is solely within the discretion of the Government. The Government reserves the right to award a contract without discussions if the Contracting Officer determines that the initial offer(s) is/are providing the Best Value and discussions are not necessary. Award will be made to the party whose quote offers the best value to the Government. The Government may award this contract to other than the lowest price technically acceptable quote. Technical capability and past performance are significantly more important than price. This solicitation is issued as a Request for Quotation (RFQ). The Food and Drug Administration (FDA) intends to award a purchase order for c1 inhibitor knockout mice. 1. Statement of Need: The supplier shall provide two breeding pairs of mice with deletion of the C1inh (Serping1) gene. Data showing absence/modification of the gene and absence of the protein shall be provided. The mice shall come with complete testing for pathogens appropriate for acceptance and transport into the 29A Animal Facility (see below pathogen list). Data on the phenotype of the mice shall be provided as well as any specific information related to the breeding, testing and appropriate maintenance of the mice. Data on the background genetics of the mice shall be provided. The background shall be that of C57bl6. If that is unavailable then the mice should have a common laboratory mouse genetic background and an H-2b haplotype for MHC. If the pairs do not survive, do not successfully breed, or the deletion is lost, the supplier shall provide a replacement pair at no additional cost. The supplier shall be available for questions regarding the breeding, maintainance, genotype and phenotype of the mice. Mice need to be available within 2-6 months. The provision of stem cells or embryos without a viable breeding pair should only be considered if no viable breeding pairs are available. Period of Performance/Basis Three years from date of award. Delivery Address 29 Lincoln Drive Bethesda, MD 20892 Pathogen screening list MICE (imported mice) MHV (mouse hepatitis virus), GDVII (mouse poliovirus), PVM (pneumonia virus of mice), Sendai virus, EDIM (epizootic diarrhea of infant mice = mouse rotavirus), CAR Bacillus, Ectromelia virus (mousepox), LCMV (lymphocytic choriomeningitis virus), MCMV (mouse cytomegalovirus), Minute virus of mice (MVM) and Mouse parvovirus (MPV), Reovirus 3, Mouse adenovirus [MAd-1(Fl), MAd-2 (K87)] , Polyomavirus, Mycoplasma pulmonis, Hantavirus, Helicobacter (H. hepaticus and H. bilis), pinworms, and mites CCR: Vendors must be registered in the Central Contractor Register (CCR) prior to the award of a contract. You may register by going to www.ccr.gov. You will need your Dun & Bradstreet number and banking information. QUESTIONS DEADLINE: All questions are to be submitted via email to Jaclyn.Stielper@fda.hhs.gov no later than August 2, 2010 at 3:00 PM EST. Telephone calls will not be accepted. QUOTATIONS DUE: All quotations are due, via email to: Jaclyn.Stielper@fda.hhs.gov , no later than 3:00 PM EST on August 7, 2010. PROVISIONS and CLAUSES: The provision at FAR 52.212-1, Instructions to Offerors Commercial Items applies to this solicitation. The following agenda has been attached to this provision: None. Offerors shall include a completed copy of the provision at FAR 52.212-3, Offeror Representations and Certifications Commercial Items. The clause at FAR 52.212-4, Contract Terms and Conditions, Commercial Items applies to this acquisition. The following agenda has been attached to the clause: None. The clause at FAR 52.212-5 Contract Terms and Conditions Required to Implement Statues or Executive Orders, Commercial Items applies to this acquisition. The following FAR clauses cited are applicable: FAR 52.217-8 Option to Extend Services (Nov 1999) , FAR 52.217-9 Option to Extend the Term of the Contract (Mar 2000) , FAR 52.222-26 Equal Opportunity (Mar 2007), FAR 52.222-35 Equal Opportunity for Special Disabled Veterans, Veterans of the Vietnam Era, and Other Eligible Veterans (Sept 2006) , FAR 52.222-36 Affirmative Action for Workers with Disabilities (June 1998) , and FAR 52.232-33 Payment by Electronic Funds Transfer-Central Contractor Registration (Oct 2003). Clauses and provisions are incorporated by reference and apply to this acquisition.