This Pre-Solicitation opportunity from Department Of Health And Human Services was posted on August 6, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.
KAIROS Microfluidic Sorter UPGRADE for S/N A0183
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The National Institutes of Health plans to award a sole-source firm-fixed-price purchase order to Apogee Flow Systems to upgrade its existing MicroPLUS Flow Cytometer located at the Laboratory of Molecular Biology in Bethesda, Maryland. The upgrade is necessary to support advanced research on bacterial heterogeneity, including the isolation of subpopulations and analysis of nanometer-scale synthetic bacterial spores and outer membrane vesicles used in anti-tumor therapeutic delivery. Two proprietary upgrades are required: the KAIROS Microfluidic Sorter Upgrade to enable precise capture of bacterial subsets for genetic and sequencing studies, and the IOTA Enhancements for Nanoscale Applications to significantly improve fluorescence sensitivity and expand the instrument’s ability to analyze submicron particles. These modifications can only be performed by Apogee Flow Systems as the original equipment manufacturer, due to proprietary technology and the requirement for direct integration into the existing system, with no authorized third-party capability. No other source can meet the technical specifications or ensure compatibility. The notice is not an invitation for competition, but responsible parties may submit capability statements by August 14, 2026, at 9:00 a.m. EDT to davisroshonna@mail.nih.gov. An award is anticipated five days after publication unless a competing capability is demonstrated. The solicitation number is 75N98026Q00958, with a NAICS code of 334516, and no small business set-aside applies.
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NAICS
Place of Performance
Bethesda, MD, 20892, USASet-Aside
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Submission Closed
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Full Description
Notice of Intent to Award a Sole Source Purchase Order
The National Institutes of Health (NIH) intends to award a Firm-Fixed-Price Purchase Order to Apogee Flow Systems.
Pursuant to FAR 6.302-1, Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements, Apogee Flow Systems is the only known responsible source capable of providing the products and services required to meet the Government's needs.
The Laboratory of Molecular Biology (LMB) requires upgrades to its existing Apogee Flow Systems MicroPLUS Flow Cytometer. The instrument is used to analyze bacterial populations for heterogeneity in behavior, reporter expression, and competitive growth.
The required upgrades include:
• KAIROS Microfluidic Sorter Upgrade – This upgrade is essential for isolating and capturing bacterial subpopulations for downstream analyses, including sequencing and genetic selection studies.
• IOTA Enhancements for Nanoscale Applications – This upgrade is required to enable the analysis of nanometer-sized synthetic bacterial spores (SSHELS) and bacterial outer membrane vesicles (OMVs) that are being developed as delivery vehicles for anti-tumor therapeutics. The enhancement will also significantly improve the instrument's fluorescence detection sensitivity.
Because these upgrades must be integrated into the LMB's existing Apogee Flow Systems MicroPLUS flow cytometer, they can only be provided by the original equipment manufacturer, Apogee Flow Systems. The manufacturer does not authorize third parties to perform these proprietary instrument upgrades. Accordingly, no other known source is capable of meeting the Government's requirement.
This notice is not a request for competitive quotations. However, any responsible source that believes it can satisfy the Government's requirement may submit a capability statement demonstrating its ability to provide the required products and services. A determination by the Government not to compete this proposed action based upon responses to this notice is solely within the discretion of the Government.
It is anticipated that an award will be issued approximately five (5) days after the publication of this notice unless the Government determines that another source has demonstrated the capability to satisfy the requirement.
Interested parties shall submit responses via email to davisroshonna@mail.nih.gov no later than 9:00 a.m. EDT on August 14, 2026.
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