Miscellaneous / Mutagenesis, Gene Synthesis, & Custom Plasmid Preparation

This is a combined Synopsis/Solicitation/Notice of Intent for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotations are not being requested and a written solicitation will not be issued for the solicitation number NIAID-NOI-13C-1622334, a Notice of Intent. The incorporated provisions and clauses are those in effect through Federal Acquisition Circular FAC 2005-66 dated February 23, 2013. This acquisition will be processed under Simplified Acquisition Procedures (SAP) and is a small business set-aside. The associated North American Industry Classification System (NAICS) Code is 541711, which has a small-business size standard is 500 employees. The National Institute of Allergy and Infectious Disease (NIAID) intends to procure Mutagenesis, Gene Synthesis and Custom Plasmid Preparation services from GenScript USA, Inc. (1) Gene Synthesis/Mutagenesis, quantity - 43; (2) Gene Synthesis/Custom Plasmid Preparation, quantity - 82; (3) Gene Synthesis/Mutagenesis, quantity - 8; (4) Gene Synthesis/Mutagenesis, quantity - 15; (5) Gene Synthesis, quantity - 6; (5) Gene Synthesis, quantity - 6; (6) Mutagenesis, quantity - 4; (7) Gene Synthesis, quantity - 2; (8) Gene Synthesis, quantity - 1; (9) Gene Synthesis, quantity - 1; (10) Gene Synthesis, quantity - 1; and (11) Gene Synthesis, quantity - 1. This requirement is to provide a synthesis of codon-optimized genes based on the sequence provided by research and the proprietary codon-optimization algorithm of the contractor, verification of synthesized gene by double stranded sequencing, subcloning of synthesized genes into vector plasmids provided by the research, and large scale preparation of DNA plasmids with a minimum yield of 1 mg. The contractor shall provide DNA preps for each construct with the sequence information of the genes of interest, quality control report of the DNA prep, DNA concentration information, and in additional bacterial glycerol stocks will be stored on-site for one (1) year. GenScript USA, Inc. has been providing this service and changing vendors at this time could be detrimental to the results of the experiments. We have been using gene synthesis and preparation services from GenScript for our protein production for more than one (1) year, and it has proven to support production of the proteins that we require for our various protocols in the development of vaccines for HIV and other viruses. Therefore we must maintain these reagent standards to insure experimental results are not influenced by other variables. Any other source of services will require extensive testing and delay our production of materials for vaccine development and trials. Place of delivery to the location of Bethesda, Maryland 20892 for one (1) year after receipt of award with various delivery requests as needed by the lab. The following factors shall be used to evaluate offers: 1) capability to meet required specifications, 2) price, and 3) delivery. The government will award a fixed price purchase order to the responsible contractor. The FOB terms are "Destination" and Net 30. FAR provisions and clauses that apply to this acquisition: FAR 52.212-1, Instructions to Offerors, Commercial Items; FAR 52.212-2, Evaluation - Commercial Items; FAR 52.212-3, Offeror Representations and Certifications - Commercial Items; FAR 52.212-4, Contract Terms and Conditions - Commercial Items; FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes of Executive Orders; and FAR 52.232-33, Payment by Electronic Funds Transfer-Central Contractor Registration (Oct 2003). A completed copy of provisions at FAR 52.212-3 Offerors Representation and Certifications Commercial Items must be included which can be found online at System for Award Management (SAM) https://www.sam.gov. By submission of an offer, the Offeror acknowledges the requirement that a prospective Awardee shall be registered in the SAM database prior to award, during performance, and through final payment of any contract, basic agreement, basic ordering agreement, or blanket purchasing agreement resulting from this solicitation. [Note: Lack of registration in SAM will make an Offeror ineligible for award.] All responsible sources may submit an offer that will be considered by the Agency. Offers must be submitted no later than 5:00 P.M. Eastern Standard Time April 19, 2013 through the U.S. Postal Service at the address of NIH/NIAID/AMOB, 10401 Fernwood Drive, Room 2NE52E, MSC 4812, Bethesda, Maryland 20892-4812. Collect calls, email and fax submissions are not accepted. Request for information concerning this requirement are to be submitted in writing, and can be faxed to 301-480-8720, or e-mail to knightte@niaid.nih.gov. It is the vendor's responsibility to confirm receipts of all quotations and/or questions by the closing date of this announcement by contacting Mr. Terry Knight at (301) 402-2282.