Next-Generation Methylation Sequencing (RRBS/WGBS)

The contract seeks to perform reduced representation or whole-genome bisulfite sequencing on fish DNA to generate comprehensive DNA methylation profiles using high-throughput sequencing platforms such as Illumina NovaSeq. The work is focused on epigenetic analysis to support research objectives under the National Oceanic and Atmospheric Administration, part of the Department of Commerce, with performance to take place in Woods Hole. The project requires advanced molecular biology and bioinformatics capabilities to process samples accurately and deliver high-quality methylation data suitable for downstream biological interpretation. This is a subcontract with a NAICS code of 541380, indicating it falls under scientific research and development services. The solicitation was posted on July 31, 2026, and responses are due by August 14, 2026. Although no set-aside classification or point of contact is specified, the clear technical scope and location of performance suggest a targeted effort to advance marine biological research through cutting-edge epigenomic techniques. Potential respondents must be equipped to handle DNA extraction, bisulfite conversion, library preparation, and sequencing on Illumina platforms, with the ability to manage large-scale genomic data output.