Preclinical Pharmacokinetic and Pharmacology Evaluations of Agents Being Developed for Cancer Patients

RFP No. N02CM67000-11 Federal Business Opportunities Announcement POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND ANY AMENDMENTS THAT MAY BE ISSUED. THIS ACQUISITION IS BEING ADVERTISED UNDER FULL AND OPEN COMPETITION. The National Institutes of Health (NIH), Toxicology & Pharmacology Branch (TPB) of the Developmental Therapeutics Program (DTP) of the Division of Cancer Treatment and Diagnosis (DCTD) of the National Cancer Institute (NCI) is seeking support services for implementation of bioanalytical methods and conduct of pharmacokinetic evaluations in animals with compounds of interest to the NCI Experimental Therapeutics (NExT) program. Analysis of samples provided by the NCI from other sources, including human clinical trials, may be requested. The purpose of this acquisition is to obtain analytical, pharmacokinetic, metabolism, pharmacodynamic, and other pharmacologic data on new agents (including small molecules, peptides, oligonucleotides, and other biologicals) for the treatment of cancer. Awardees will implement and validate appropriate established analytical methods to quantify compounds in biological fluids and tissues from multiple species and rapid pharmacokinetic assessments to the NCI. Data generated will be used in all phases of the drug development process, from lead selection and development to the support of early clinical trials. For those agents that are selected for clinical trial, the reports generated under these contracts will comprise a portion of the IND submission to the FDA. Request for Proposal (RFP) N02CM67000-11 will be available on or about February 22, 2016 and receipt of proposals will be due at 2:00 p.m., Eastern Prevailing Time on March 22, 2016. The RFP will only be available electronically and must be accessed through the FedBizOpps website and the National Cancer Institutes' homepage at http://ncioa.cancer.gov/oa-internet/. Once there, click on Solicitations. All information required for submission of a proposal will be contained under the electronic RFP package. It is the offeror's responsibility to monitor the above Websites for the release of this RFP and amendments, if any. All responsible sources may submit a proposal, which shall be considered by the agency. This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted. This solicitation is anticipated to result in five (5) awards to offerors capable of performing all aspects of the work described in the Statement of Work (SOW). It is anticipated that five indefinite delivery, indefinite quantity (IDIQ) contracts will be awarded on or before July 1, 2016, for a five year period of performance. Task Orders will be awarded against the IDIQ. The Government's estimated effort for the first Task Order is approximately 16 direct labor hours. This advertisement does not commit the Government to award any contract. The North American Industry Classification System (NAICS) code is 541990, with a size standard of $15.0 million. This is a recompetition of the following contracts listed below: HHSN261201100012C SRI International HHSN261201100013C Southern Research Institute HHSN261201100014C Mayo Clinic HHSN261201100015C University of Pittsburgh HHSN261201100016C University of California - San Francisco The period of performance for these contracts was five-years. Freedom of Information Act (FOIA) requests regarding the current contracts listed above, should be directed to Suzy Milliard at milliars@mail.nih.gov. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE RFP AND ANY POSSIBLE AMENDMENTS, FAILURE TO DO SO WILL BE AT YOUR FIRM'S OWN RISK. ALL INQUIRIES SHALL BE SUBMITTED ELECTRONICALLY TO THE CONTRACTING OFFICER LISTED AS THE POINT OF CONTACT HEREIN. Point of Contacts: Alexis Hudak, Contracting Officer; Phone: 301-624-8753; Email: alexis.hudak@nih.gov. Lynne Schneider, Contracting Officer/Team Lead; Phone: 301-624-8746; Email: lynne.schneider@nih.gov.