Prospective Studies of Telomere Length Dynamics and Type 2 Diabetes Related Outcomes

This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NICHD201700296 and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-95. The North American Industry Classification (NAICS) Code is 541380 and the business size standard is 1000 employees. However, this solicitation is not set aside for small business. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intend to contract on a sole source basis with University of California, San Francisco, Biochemistry and Biophysics; San Francisco CA 94158, MN 55455, for the services Prospective Studies of Telomere Length Dynamics and Type 2 Diabetes Related Outcomes. Telomere length measurement Average TL in peripheral white blood cells will be measured using a validated quantitative polymerase chain reaction (Q-PCR) method which measures the relative average TL in genomic DNA by determining the ratio of telomere repeat copy number to single-copy gene copy number (T/S ratio) in experimental samples relative to a reference sample. The T signal for an experimental DNA sample is the number of nanograms of the reference DNA that matches the experimental sample for copy number of the telomere repeats. The S signal is the number of nanograms of the reference DNA that matches the experimental sample for copy number of the single-copy gene. Experimental samples with T/S >1.0 have longer average TLs than the reference DNA. All samples will be measured in triplicate, and the mean value will be used for analysis. Tasks to be performed 1. Processing: 10 ?L of DNA sample at a concentration of 100 ng/ ?L will be shipped. A total of 3 ?L will be used for the assay and the remaining 7 ?L of samples will be returned to us. In other words, no more than 300 ng of genomic DNA per sample is needed. 2. Q-PCR assay: the assay will be carried out in triplicate, and the mean value will be calculated for each sample. The offeror must include a completed copy of the provision of FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items with its offer. The provisions of FAR Clause 52.212-1 Instructions to Offerors - Commercial Items; FAR Clause 52.212-2, Evaluation - Commercial Items; FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions applies to this acquisition. The offeror must include their Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. The clauses are available in full text at http://www.acquisition.gov/far/. Interested vendors capable of furnishing the government with the all the products and or services specified in this synopsis should submit a copy of their quotation to the below address or via email to ryan.hash@nih.gov. Offers must also be accompanied by descriptive literature, delivery timeframe, warranties and/or other information that demonstrates that the offer meets all of the foregoing requirements. Quotations will be due September 19, 2017 before 10:00 am EDT. via email or postal mail. The quotation must reference "Solicitation number" NICHD201700296. Quotations sent by postal mail or other mailing services must be submitted to the following address: Eunice Kennedy Shriver National Institute of Child Health and Human Development - 6710B Rockledge Drive, Room MSC 1145A, Bethesda, MD 20892. Note: Fed Ex/Ups/other courier use 20817. Attention: Ryan Hash, by the date and time mentioned above. Any questions must be sent via email to ryan.hash@nih.gov and must include solicitation# NICHD201700296 in the subject line of email. Faxed copies/responses will not be accepted. Email solicitations not accepted. Note: In order to receive an award, contractor must be registered and have valid certification for all awards in the SAM database @www.sam.gov