Top

Q--Histopathological Analysis

Active

RFQ-RT-17-00016Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

The U.S. Environmental Protection Agency seeks to contract Pathogenesis, LLC on a sole source basis to conduct a histopathological evaluation of the toxic effects of six freshwater cyanobacterial microcystin toxins in mice. This study aims to generate data that will inform the Office of Water's regulatory standards for human exposure through recreational and drinking water. The research requires specialized immunohistochemistry techniques, such as Caspase-3 staining to detect apoptosis and actin-specific staining to assess organ-specific toxicity, methods previously employed by Pathogenesis in collaboration with the EPA. Maintaining consistency with prior studies is essential for reliable data comparison and statistical analysis. This procurement is planned to proceed without full and open competition under the Federal Acquisition Regulation clause allowing solicitation from a single source. However, other interested parties are invited to submit detailed capability statements and itemized pricing within seven days to demonstrate competition feasibility. Routine requests for additional information or solicitations for a statement of work will not be entertained. Responses must be submitted in writing electronically or by mail to the designated EPA contact, with no telephone or fax inquiries accepted. The effort supports the efficient use of EPA resources and aims to maximize the quality and scope of toxicological data for regulatory decision-making.

General Info

EPA contracts Pathogenesis, LLC for single-source toxicological study on cyanobacterial microcystin effects.

Agency

Environmental Protection Agency → Information Technology Acq Division (ita

NAICS

541380 - Testing Laboratories and Services

Place of Performance

Set-Aside

NONE

Documents

No documents available

Documents will appear here when they are available.

AI Contract Breakdown

Uniform Contract Format

No documents to break down

The breakdown needs solicitation documents. None were found from this contract's source.

Timeline

PostedJan 18

special-notice

Ready to pursue this opportunity?

Get full access to track this contract, build proposals with AI assistance, and manage your pipeline.

Organization & Contact Information

AgencyEnvironmental Protection Agency → Information Technology Acq Division (ita

ContactsNo contacts available

OfficeDurham, NC, 27709, USA

Organization / AgencyEnvironmental Protection Agency → Information Technology Acq Division (ita

Office AddressDurham, NC, 27709, USA

ContactsNo contact information available

Full Description

Histopathological Analysis RFQ-RT-17-00016 Notice of Intent The U.S Environmental Protection Agency (EPA) intends to negotiate on a sole source basis with Pathogenesis, LLC to evaluate the toxic effects of six freshwater cyanobacterial toxins, including, the microcystins (MCYST) congeners: MCLR, MCRR, MCLA MCYR, MCLY, and MCLF* in mice. This procurement is recommended to be processed without full and open competition. * MC=microcystin; MCLR=microcystin-LR (L=leucine, R=arginine); MCRR, MCLA, MCLF, MCLY, MCYR (Y= tyrosine, A=alanine , F=phenylalanine) The evaluation of this study will be used by the Office of Water to help set regulations on human exposure to these toxins through recreational water contact and drinking water ingestion. It is important to maximize the breadth, depth, and accuracy of available data from these research samples so the National Health Effects and Environmental Research Laboratory (NHEERL) resources are used efficiently and efficaciously. Pathogenesis, LLC has experience in specific immunohistochemistry (IHC) stains (Caspase-3) to identify apoptosis and has used actin-specific IHC to identify a mechanism of action and highlight the extent of the organ-specific toxicity. Pathogenesis, LLC has also identified toxicity endpoints and applied a scoring system for representing the physical findings as numerical data for statistical analysis under a similar previous study with the EPA. It is critical that the Agency utilizes the same techniques that were used under the previous study for data comparisons. The circumstance permitting is FAR 13.106-1 (b) (1) ¿Soliciting from a single source¿. All interested parties who believe they can provide the required product should fully explain their capabilities and qualifications in writing within 7 days from the date of this announcement and provide itemized pricing that is sufficient to make a determination that competition is feasible. The intent of this notice is to determine if any other source(s) exist, and therefore, no solicitation is available. Consequently, anyone failing to provide the aforementioned and instead chooses to merely submit a routine letter requesting a copy of the statement of work or more information about the project will be ignored. The information received to this notice will be considered solely for the purpose of determining whether or not to conduct a competitive procurement. Please submit response to Marsha Johnson at contact@example.gov or to the U.S. EPA, Attn: Marsha Johnson (AA-005), RTP Procurement Operations Division, 109 Alexander Drive, Research Triangle Park, NC 27709. No telephone or faxed requests will be honored.