RECOVERY: In Vitro Screening of Combinations of Chemotherapy Drugs
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The contract awarded to SRI International on September 20, 2010, involves a cost reimbursement agreement valued at $3.1 million for in vitro screening of chemotherapy drug combinations. The project leverages advanced molecular biology techniques—including genomics, iRNA, and proteomics—along with computational and statistical modeling, such as response surface mapping for synergy, and robotics to enhance drug screening processes. The contract was competitively procured, and its nature required a cost reimbursement model due to the complexity and unpredictability of costs, making a fixed-price approach unsuitable. This undertaking focuses on applying state-of-the-art scientific methods to optimize chemotherapy drug combinations, aiming to improve therapeutic outcomes. The contract includes stringent measures to ensure that all costs are allowable, allocable, fair, and reasonable. The solicitation falls under NAICS code 541711, relating to research and development in biotechnology, with oversight by Contracting Officer Stanley A. Knight. The overall scope emphasizes the integration of multidisciplinary techniques in a research-focused environment to accelerate drug discovery efforts.
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