Resuscitation and Prevention of Ischemia-Induced Dysfunction (RAPIID) - TA1/TA2

The Resuscitation and Prevention of Ischemia-induced Dysfunction (RAPIID) program, under solicitation DARPA-PS-26-124, seeks innovative proposals for Phase 1 of Task Areas 1 and 2 to develop a transformative, fieldable resuscitation system that replaces stored whole blood with a shelf-stable, scalable Blood Analog System (BAS). This system comprises sequentially administered blood analog components—such as oxygen carriers, dried plasma, and platelet-like particles—and integrated point-of-care diagnostics and delivery devices, all designed to function without reliance on cold chain logistics or donor dependency. Proposers must demonstrate technical feasibility, achievement of specified milestones, and readiness for transition to higher technology readiness levels (TRL-7 for blood analog components and TRL-8 for diagnostic devices), with strict adherence to packaging and stability requirements including demonstrated shelf-life of at least three, six, and twelve months in government-chosen packaging under varying temperature conditions. Coordination with Task Areas 3 and 4 focused on regulatory strategy and commercialization is mandatory, ensuring that all innovations are designed with eventual field adoption and scalability in mind. Proposals must be submitted via DARPA’s Broad Agency Announcement Tool by June 24, 2026, and are evaluated on scientific and technical merit—including team expertise, execution plan, risk mitigation, and past performance—and cost efficiency, with an emphasis on leveraging prior research to maximize funding impact. The award will be structured as an Other Transaction (OT) Agreement under a Model Other Transaction for Prototype Agreement, not a traditional contract, and thus governed by Articles instead of FAR clauses, with key provisions including data rights aligned with DFARS 252.227-7026 and 252.227-7027, patent rights, and controlled unclassified information (CUI) management per the RAPIID CUI Guide and NIST SP 800-171. Financial terms are milestone-driven, requiring electronic invoicing through WAWF with Defense Finance and Accounting Services processing payments within 30 days of acceptance, linked to specific CLINs and ACRNs tied to deliverables. Proposer eligibility excludes federally funded research centers, university-affiliated research centers, and government entities, and all submissions must be unclassified, properly marked if proprietary, and accompanied by required certifications including SAM.gov UEI, CAGE code, and TIN. Payment schedules, budget justifications, and cost breakdowns must conform to