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NAICS Code· 541714

Research and Development in Biotechnology (except Nanobiotechnology)

This U.S. industry comprises establishments primarily engaged in conducting biotechnology (except nanobiotechnology) research and experimental development. Biotechnology (except nanobiotechnology) research and experimental development involves the study of the use of microorganisms and cellular and biomolecular processes to develop or alter living or non-living materials. This research and development in biotechnology (except nanobiotechnology) may result in development of new biotechnology (except nanobiotechnology) processes or in prototypes of new or genetically-altered products that may be reproduced, utilized, or implemented by various industries. Illustrative Examples: Cloning research and experimental development laboratories DNA technologies (e.g., microarrays) research and experimental development laboratories Nucleic acid chemistry research and experimental development laboratories Protein engineering research and experimental development laboratories Recombinant DNA research and experimental development laboratories Cross-References. Establishments primarily engaged in--Show more

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms. This sector supports federal initiatives in precision medicine, infectious disease mitigation, biosecurity, and advanced bioprocessing, often involving recombinant DNA technology, protein engineering, cell line development, and high-throughput screening.

65
Active Contracts
$1.2B
Total Obligations (12mo)
496
Awarded Contracts (12mo)
338
Contractors Awarded (12mo)
-86.2%
YoY Growth

Industry Spending Overview

Federal obligations, top contractors and agencies, and related industry codes for NAICS 541714.

AI Industry Description

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms...

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms. This sector supports federal initiatives in precision medicine, infectious disease mitigation, biosecurity, and advanced bioprocessing, often involving recombinant DNA technology, protein engineering, cell line development, and high-throughput screening. In the government contracting landscape, this NAICS code serves as a critical conduit for translating academic and private-sector biotech innovations into mission-critical public health and defense capabilities, frequently intersecting with biomedical engineering, regulatory science, and clinical trial design. Top contractors in this space include Deloitte Consulting LLP, CFD Research Corporation, and PM Consulting Group LLC, reflecting a mix of large professional services firms and specialized small businesses with deep expertise in biostatistics, bioinformatics, and translational research. These firms often serve as technical integrators, bridging laboratory discoveries with scalable, compliant, and government-ready solutions, particularly in areas requiring FDA-aligned development pathways or defense-relevant biosurveillance capabilities. The Department of Health and Human Services and the Department of Defense are the primary awarding agencies, with HHS funding biomedical innovation through NIH and BARDA programs, while DoD supports biodefense, battlefield medical readiness, and countering biological threats through agencies like DARPA and the U.S. Army Medical Research and Development Command. Demand is driven by pandemic preparedness, medical countermeasure development, and next-generation biothreat detection systems. The competitive landscape is highly technical and innovation-driven, with opportunities concentrated in contract research organizations, specialized R&D services, and government-sponsored translational partnerships. Contractors with proven experience in GMP compliance, biosafety level containment, and federal regulatory submission processes are best positioned to compete in this high-stakes, mission-critical sector.

Top Contractors

Companies with the highest total award value under NAICS 541714, ranked by dollars won.

Ranked by total awards
CompanyTotal AwardsContracts
ALBERT B. SABIN VACCINE INSTITUTE, INC. (THE)$223.8M1
SHIONOGI INC$119.2M1
CHENEGA SERVICES & FEDERAL SOLUTIONS, LLC$72.4M1
CIDARA THERAPEUTICS INC$58.1M1
TRANQUIL CLINICAL AND RESEARCH CONSULTING SERVICES LLC Webster TX 77598 USA$50.0M1
Coriell Institute for Medical Research, Inc. Camden NJ 08103 USA$48.3M1
VERICEL CORPORATION$34.9M1
UNIVERSITY OF MIAMI$28.3M2
SANOFI VACCINES US INC.$25.6M2
BIOSPYDER TECHNOLOGIES, INC. PO BOX 402 Rancho Santa Fe CA 92067 USA$25.0M1

Top Agencies

Federal agencies directing the most contract spending toward NAICS 541714.

Department Of Health And Human Services169 awards$680.1M
National Institutes Of Health Nida3 awards$75.0M
Defense Health Agency1 award$72.4M
Department Of Defense59 awards$60.3M
Department Of Health And Human Services (hhs)115 awards$57.5M
FDA Office Of Acq Grant Svcs1 award$50.0M
Department Of Veterans Affairs52 awards$26.0M
Aspr Barda Division Contracts Management & Acq2 awards$25.7M
FA8650 USAF Afmc Afrl Pzl Afrl/pzl1 award$25.0M
Cincinnati Acquisition Division (cad)1 award$25.0M

Related NAICS Codes

Industries similar to Research and Development in Biotechnology (except Nanobiotechnology), by shared sector, subsector, and industry group.

Research and Development in Nanotechnology

This U.S. industry comprises establishments primarily engaged in conducting nanotechnology research ...
541713Same Industry GroupHigh Similarity

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

This U.S. industry comprises establishments primarily engaged in conducting research and experimenta...
541715Same Industry GroupHigh Similarity

Research and Development in the Social Sciences and Humanities

This industry comprises establishments primarily engaged in conducting research and analyses in cogn...
541720Same Industry GroupHigh Similarity

Offices of Lawyers

This industry comprises offices of legal practitioners known as lawyers or attorneys (i.e., counselo...
541110Same SubsectorMedium Similarity

Offices of Notaries

This industry comprises establishments (except offices of lawyers and attorneys) primarily engaged i...
541120Same SubsectorMedium Similarity

title Abstract and Settlement Offices

This U.S. industry comprises establishments (except offices of lawyers and attorneys) primarily enga...
541191Same SubsectorMedium Similarity

All Other Legal Services

This U.S. industry comprises establishments of legal practitioners (except offices of lawyers and at...
541199Same SubsectorMedium Similarity

Offices of Certified Public Accountants

This U.S. industry comprises establishments of accountants that are certified to audit the accountin...
541211Same SubsectorMedium Similarity

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NAICS 541714 FAQ

Frequently Asked Questions

NAICS code 541714 covers Research and Development in Biotechnology (except Nanobiotechnology). This U.S. industry comprises establishments primarily engaged in conducting biotechnology (except nanobiotechnology) research and experimental development. Biotechnology (except nanobiotechnology) research and experimental development involves the study of the use of microorganisms and cellular and biomolecular processes to develop or alter living or non-living materials. This research and development in biotechnology (except nanobiotechnology) may result in development of new biotechnology (except nanobiotechnology) processes or in prototypes of new or genetically-altered products that may be reproduced, utilized, or implemented by various industries. Illustrative Examples: Cloning research and experimental development laboratories DNA technologies (e.g., microarrays) research and experimental development laboratories Nucleic acid chemistry research and experimental development laboratories Protein engineering research and experimental development laboratories Recombinant DNA research and experimental development laboratories Cross-References. Establishments primarily engaged in--

Recently Posted in Research and Development in Biotechnology (except Nanobiotechnology)

NAICS: 541714
New
Federal
Purchase of Methylation Custom Probes for sequencing
National Institutes Of Health Olao

POSTED

about 14 hours ago

DEADLINE

in 7 days
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NAICS: 541714
New
Federal
Multiscale Reasoning For Human Physiology RFIThe Defense Advanced Research Projects Agency’s Biological Technologies Office is seeking input on cutting-edge technologies that enable multiscale reasoning across human physiology through this Request for Information, identified as DARPA-SN-26-100. The focus is on emerging tools including artificial intelligence systems, foundation models, computational frameworks, and datasets capable of integrating biological, physiological, and clinical data across multiple scales—from molecular and cellular levels to organ systems and whole-body responses. The goal is to advance the ability to model, predict, and interpret complex human physiological behavior using AI and data-driven approaches, with interest in non-traditional performers and innovative solutions from industry, academia, government labs, and healthcare organizations. Responses are due by August 10, 2026, and the solicitation falls under NAICS code 541714 for research and development in the physical, engineering, and life sciences. All submissions should be directed to Dr. Roozbeh Jafari, Program Manager at DARPA/BTO, via bioreasoning@darpa.mil. The office is located in Arlington, Virginia, and while no specific place of performance is defined, selected technologies may be developed and evaluated through future DARPA programs. This RFI does not constitute a solicitation for proposals or obligations but aims to inform upcoming funding opportunities in the field of physiological modeling and AI-driven biological insight.
Defense Advanced Research Projects Agcy

POSTED

1 day ago

DEADLINE

in 26 days
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NAICS: 541714
New
Federal
Technical Support and Product Training for EMIT Assay SystemsThe contract provides for on-site or remote technical assistance, system calibration, and training services specifically tailored for laboratory personnel working with EMIT II Plus Assay systems and their associated reagents. This support is critical to ensure accurate operation, proper maintenance, and effective use of the analytical equipment, enabling consistent and reliable test results in laboratory settings. The scope encompasses hands-on training, troubleshooting guidance, and periodic calibration to meet performance standards, with services deliverable either at the client’s facility or through virtual means as needed. This subcontract is associated with the Department of Defense under the agency identifier FA3016 502 Cons Cl and is classified under NAICS code 541714, indicating scientific and technical consulting services. The place of performance is designated as DWG with a zip code of 78236, suggesting the primary operational location is in or near San Antonio, Texas. The solicitation was posted on July 10, 2026, with a response deadline of July 20, 2026, at 3:00 PM, requiring interested parties to submit proposals within this narrow window. The contract does not specify any set-aside status, and no point of contact information has been provided in the posting.
FA3016 502 Cons Cl

POSTED

5 days ago

DEADLINE

in 6 days
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NAICS: 541714
Closed
Federal
Bovine IFN Lambda Fc FusionThe solicitation, numbered 1232SA26Q0916, seeks quotations for Bovine IFN Lambda Fc Fusion under a combined synopsis and solicitation format compliant with FAR Part 12, meaning no separate written solicitation will be issued. This is an unrestricted commercial acquisition with no set-aside provisions, open to all responsible sources regardless of business size, though the small business size standard is defined as 1000 employees. The North American Industry Classification System code is 541714, indicating it pertains to research and development in the physical, engineering, and life sciences. The posting date is July 10, 2026, with a response deadline of July 13, 2026, at 6:00 PM Eastern Time. The procurement is managed by the USDA ARS AFM APD, located in Beltsville, Maryland, with performance required in Manhattan, Kansas, ZIP 66502. Primary point of contact is Erin Riffey, reachable via email at erin.riffey@usda.gov or phone at 970-631-2294. Further details and submissions must be made through the provided SAM.gov link, as this announcement serves as the sole solicitation document.
USDA Ars Afm Apd

POSTED

5 days ago

CLOSED

1 day ago
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NAICS: 541714
New
Federal
Tape-Out Ready Physical Design & EDA SupportThe contract requires the production of GDSII and OASIS layout files along with IBIS models, S-parameters, and eye diagrams to validate signal and power integrity for tape-out readiness on Intel’s 18A process node. All deliverables must meet stringent industry standards to ensure the physical design is fully optimized and compliant for manufacturing, with a focus on minimizing signal degradation, electromagnetic interference, and power delivery issues. The work must be executed with precision to support seamless transition from design to fabrication, ensuring the final product meets electrical and performance targets. This is a subcontract under NAICS code 541714, issued by the Department of Defense via FA8002 Saf Aq, with a response deadline of July 23, 2026, and a posting date of July 8, 2026. The place of performance and specific point of contact are not detailed in the provided data, but the scope clearly demands advanced EDA expertise and close alignment with Intel’s 18A process requirements. All deliverables must be submitted in recognized industry formats and accompanied by verification data to confirm compliance with reliability and performance benchmarks necessary for defense applications.
FA8002 Saf Aq

POSTED

7 days ago

DEADLINE

in 9 days
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NAICS: 541714
New
Federal
Secure Enclave Integration & Validation ServicesThe contract seeks qualified vendors to validate chiplet designs within the Government’s Secure Enclave, specifically focusing on adherence to open industry standards such as UCIe. This work involves the secure handling, rigorous testing, and comprehensive verification of chiplet interoperability to ensure compatibility, reliability, and protection of sensitive hardware architectures. All activities must comply with stringent security protocols mandated by the Department of Defense to safeguard intellectual property and maintain the integrity of the Secure Enclave environment throughout the validation lifecycle. Performance is expected to align with the NAICS code 541714, indicating specialized research and development in engineering services. The subcontract opportunity is open for response until July 23, 2026, and is administered by the Saf Aq office under the Department of Defense. While specific location details are not provided, all work must be conducted in a manner that meets federal security requirements, and successful bidders must demonstrate proven expertise in secure chiplet validation, open standard implementation, and secure testing methodologies within defense-critical systems.
FA8002 Saf Aq

POSTED

7 days ago

DEADLINE

in 9 days
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NAICS: 541714
Awarded
Federal
Methylome End to End Samples Processing ServicesTwist Bioscience Corporation, recognized as a small business with unique capability, has been sole-source awarded for Methylome End to End Samples Processing Services under solicitation 36C26226P1118 due to its exclusive ability to deliver high-end methylome sequencing services requiring enzyme-linked target sequencing, specific experimental protocols, and methylation panels, all while generating high-quality libraries from just 60 ng of cell-free DNA with a non-CpG conversion rate exceeding 99%. No other vendor can meet these highly specialized technical requirements without jeopardizing the validity, accuracy, and success of the research, as demonstrated by the successful completion of prior work with the same provider. The contract was issued in accordance with FAR 13.106-1(b)(1) to ensure continuity and reliability, with performance to be conducted at Twist Bioscience’s facility in South San Francisco, California, while the contracting office is located in Gilbert, Arizona, under the Department of Veterans Affairs, 262-NETWORK Contract Office 22.
262-NETWORK Contract Office 22 (36C262)

POSTED

8 days ago

DEADLINE

N/A
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NAICS: 541714
Federal
Request for Service: Pulse Field Ablation Comparative Assessment DevelopmentThe U.S. Food and Drug Administration’s Office of Acquisitions and Grants Services, under the Department of Health and Human Services, has issued a solicitation for the development of a comparative assessment of pulse field ablation technologies. This is a total small business set-aside contracting opportunity designated under FAR 19.5, exclusively available to small businesses as defined by the Small Business Administration. The solicitation, identified as SB134042, was posted on July 7, 2026, with questions due by 10 AM EST on July 10, 2026, and proposals must be submitted no later than 10 AM EST on July 20, 2026. The contract falls under NAICS code 541714, which covers research and development in the physical, engineering, and life sciences. The work is to be performed in Rockville, Maryland, and all inquiries and submissions should be directed to Telisha Wilson at telisha.wilson@fda.hhs.gov. The contract aims to advance comparative evaluation methodologies for pulse field ablation systems, supporting regulatory science objectives within the FDA’s mission.
FDA Office Of Acquisitions And Grants Services

POSTED

8 days ago

DEADLINE

in 5 days
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NAICS: 541714
Grant
Renewable Energy and Solar Grid Integration R&DThe contract titled Renewable Energy and Solar Grid Integration R&D is a subcontract aimed at advancing solar energy systems, battery storage, and smart grid integration specifically designed for arid climates through joint research efforts involving U.S., Israeli, and MENA region partners. The initiative focuses on developing technologies that enhance energy resilience, efficiency, and reliability in hot, dry environments where traditional energy infrastructure faces unique challenges. Collaborative innovation is central to the project, with an explicit goal of moving researched solutions toward commercial viability, ensuring practical deployment and market adoption in regions with high solar potential but limited water and grid stability resources. Research activities under this contract must be completed and tested by the response deadline of September 30, 2026, following a July 6, 2026 posting date. The work is classified under the NAICS code 541714, indicating it falls within research and development in the physical, engineering, and life sciences. Administration is handled by the Department of State’s Assistance Coordination office, though no specific location for performance or contact details are provided. The subcontract seeks to leverage international expertise to create scalable, localized energy solutions, with an emphasis on cross-border cooperation and technology transfer to support sustainable development and energy security in arid zones.
Assistance Coordination

POSTED

9 days ago

DEADLINE

in 3 months
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NAICS: 541714
Grant
Agricultural Technology and Climate-Resilient Farming SystemsThe contract seeks to advance food security in arid regions by developing and deploying precision agriculture technologies, drought-resistant crop varieties, and real-time soil health monitoring systems through field trials and collaborative regional partnerships. Emphasis will be placed on co-development with local stakeholders to ensure solutions are contextually appropriate, scalable, and sustainable under climatic stressors. The initiative spans research, field implementation, and adaptive management, aiming to bridge technological innovation with on-the-ground agricultural resilience. Work under this subcontract is governed by NAICS code 541714 and is administered by the Department of State through its Assistance Coordination office. Proposals must be submitted by September 30, 2026, with activities expected to occur in arid regions where traditional farming practices are increasingly challenged. The project requires demonstration of technical feasibility, community engagement, and measurable improvements in crop yields and soil vitality. No set-aside provisions apply, and performance locations are not specified, allowing flexibility for deployment across targeted dryland areas worldwide.
Assistance Coordination

POSTED

9 days ago

DEADLINE

in 3 months
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NAICS: 541714
Federal
Resuscitation and Prevention of Ischemia-Induced Dysfunction (RAPIID) - TA3The RAPIID program, specifically Task Area 3, aims to bridge the gap between lab-scale breakthroughs in shelf-stable blood analogs and real-world deployment by advancing the regulatory approval, manufacturing scalability, and field usability of components originally developed under the FSHARP program. These components, designed to replicate the critical functions of whole blood—oxygen delivery, hemostasis, and volume expansion—now require rigorous clinical validation to demonstrate safety and efficacy when used in combination, as well as scalable production processes to ensure consistent, high-volume output. Efforts under this solicitation will focus on pushing these technologies through the regulatory pathway to secure necessary approvals for military and civilian use in austere, pre-hospital environments. The initiative seeks to develop and scale enabling fielding technologies that support the deployment, storage, and administration of these blood analogs outside controlled laboratory settings. This includes not only the components themselves but also the logistical and operational frameworks needed to integrate them into frontline medical workflows. Proposals must address the full spectrum of challenges—from manufacturing robustness and regulatory compliance to usability in extreme conditions—while aligning with the program’s goal of delivering a complete, authorized system capable of saving lives where traditional blood supplies are unavailable. The solicitation, issued by DARPA’s Biological Technologies Office, has a response deadline of July 29, 2026, and is open to all qualified entities, targeting the NAICS code 541714 for research and development in physical, engineering, and life sciences.
Defense Advanced Research Projects Agcy

POSTED

13 days ago

DEADLINE

in 15 days
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NAICS: 541714
Closed
Federal
Chromosome Conformation and Whole Genome Sequencing - KINGSTON RIThis contract solicitation seeks quotations for chromosome conformation and whole genome sequencing services under solicitation number 1232SA26Q0618, issued as a combined synopsis and request for quotation in accordance with FAR Part 12. The acquisition is exclusively reserved for small business concerns, with a total small business set-aside designation, and is restricted to entities that do not exceed 1,000 employees as defined by the North American Industry Classification System code 541714. All responsible small businesses are eligible to submit a quote, and no separate written solicitation will be issued—this announcement serves as the complete and only solicitation document. The work is to be performed in Kingston, Rhode Island, with the contracting office located in Beltsville, Maryland, under the auspices of the USDA Agricultural Research Service. The solicitation was posted on July 2, 2026, and responses are due by July 10, 2026, at 10:00 PM Eastern Time. All inquiries should be directed to Shane Pope, the primary point of contact, via email at shane.pope@usda.gov or by phone at 970-851-3735. The opportunity is accessible through the SAM.gov platform, and bidders must ensure full compliance with federal commercial item procurement guidelines.
USDA Ars Afm Apd

POSTED

13 days ago

CLOSED

4 days ago
View Details

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