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NAICS Code· 541714

NAICS 541714: Research and Development in Biotechnology (except Nanobiotechnology)

This U.S. industry comprises establishments primarily engaged in conducting biotechnology (except nanobiotechnology) research and experimental development. Biotechnology (except nanobiotechnology) research and experimental development involves the study of the use of microorganisms and cellular and biomolecular processes to develop or alter living or non-living materials. This research and development in biotechnology (except nanobiotechnology) may result in development of new biotechnology (except nanobiotechnology) processes or in prototypes of new or genetically-altered products that may be reproduced, utilized, or implemented by various industries. Illustrative Examples: Cloning research and experimental development laboratories DNA technologies (e.g., microarrays) research and experimental development laboratories Nucleic acid chemistry research and experimental development laboratories Protein engineering research and experimental development laboratories Recombinant DNA research and experimental development laboratories Cross-References. Establishments primarily engaged in--Show more

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms. This sector supports federal initiatives in precision medicine, infectious disease mitigation, biosecurity, and advanced bioprocessing, often involving recombinant DNA technology, protein engineering, cell line development, and high-throughput screening.

119
Active Contracts
$968.4M
Total Obligations (12mo)
422
Awarded Contracts (12mo)
290
Contractors Awarded (12mo)
1
Median Bidders per Award
-23.0%
YoY Growth

Industry Spending Overview

Federal obligations, top contractors and agencies, and related industry codes for NAICS 541714.

AI Industry Description

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms...

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms. This sector supports federal initiatives in precision medicine, infectious disease mitigation, biosecurity, and advanced bioprocessing, often involving recombinant DNA technology, protein engineering, cell line development, and high-throughput screening. In the government contracting landscape, this NAICS code serves as a critical conduit for translating academic and private-sector biotech innovations into mission-critical public health and defense capabilities, frequently intersecting with biomedical engineering, regulatory science, and clinical trial design. Top contractors in this space include Deloitte Consulting LLP, CFD Research Corporation, and PM Consulting Group LLC, reflecting a mix of large professional services firms and specialized small businesses with deep expertise in biostatistics, bioinformatics, and translational research. These firms often serve as technical integrators, bridging laboratory discoveries with scalable, compliant, and government-ready solutions, particularly in areas requiring FDA-aligned development pathways or defense-relevant biosurveillance capabilities. The Department of Health and Human Services and the Department of Defense are the primary awarding agencies, with HHS funding biomedical innovation through NIH and BARDA programs, while DoD supports biodefense, battlefield medical readiness, and countering biological threats through agencies like DARPA and the U.S. Army Medical Research and Development Command. Demand is driven by pandemic preparedness, medical countermeasure development, and next-generation biothreat detection systems. The competitive landscape is highly technical and innovation-driven, with opportunities concentrated in contract research organizations, specialized R&D services, and government-sponsored translational partnerships. Contractors with proven experience in GMP compliance, biosafety level containment, and federal regulatory submission processes are best positioned to compete in this high-stakes, mission-critical sector.

Top Contractors

Companies with the highest total award value under NAICS 541714, ranked by dollars won.

Ranked by total awards
CompanyTotal AwardsContracts
ALBERT B. SABIN VACCINE INSTITUTE, INC. (THE)$223.8M1
SHIONOGI INC$119.2M1
CHENEGA SERVICES & FEDERAL SOLUTIONS, LLC$72.4M1
CIDARA THERAPEUTICS INC$58.1M1
VERICEL CORPORATION$34.9M1
UNIVERSITY OF MIAMI$28.3M2
SANOFI VACCINES US INC.$25.6M2
BATTELLE MEMORIAL INSTITUTE$25.3M8
UES INC Dayton OH 45432 USA$25.0M1
CHENEGA PROFESSIONAL & TECHNICAL SERVICES LLC$20.6M2

Top Agencies

Federal agencies directing the most contract spending toward NAICS 541714.

Department Of Health And Human Services146 awards$640.9M
Defense Health Agency1 award$72.4M
Department Of Defense45 awards$66.1M
Department Of Health And Human Services (hhs)108 awards$54.0M
National Institutes Of Health Nida1 award$26.6M
Department Of Veterans Affairs48 awards$25.8M
FA8650 USAF Afmc Afrl Pzl Afrl/pzl1 award$25.0M
FDA Office Of Acquisitions And Grants Services1 award$16.7M
Army Medical Resources Acq Activity1 award$11.5M
National Aeronautics And Space Administration13 awards$10.7M

Competition

How many companies historically bid on federal awards in NAICS 541714, from bidder counts reported on USAspending.

Usually Single-Bid

Half or more of reported awards drew exactly one bidder, usually a sign of incumbent-held work rather than an open field. · 4,517 reported awards

Median Bidders

1

Per reported award, all-time

Single-Bid Awards

65%

Share of reported awards with one bidder

10+ Bidder Awards

14%

Share of reported awards with 10+ bidders

Reported Awards

0

87% of 5,191 total awards

How this code compares up the NAICS hierarchy. Parent cohorts pool every code under their prefix, so they are the steadier baseline when a 6-digit sample is thin.

Industry FamilyCompetitionMedian BiddersSingle-BidBidder MixReported Awards
541714This Code
Research and Development in Biotechnology (except Nanobiotechnology)
Usually Single-Bid165%
4,51787% of 5,191
54171NAICS Industry
Fewer Bidders242%
246,23282% of 298,540
5417Industry Group
Scientific Research and Development Services
Fewer Bidders240%
282,50484% of 338,034
541Subsector
Fewer Bidders249%
2,915,44885% of 3,412,306
54Sector
Professional, Scientific, and Technical Services
Fewer Bidders249%
2,915,44885% of 3,412,306

Bidder counts reported on past federal awards in this NAICS (USAspending). An open opportunity has no bidders yet, so this is the historical norm for similar work, not a fact about this solicitation. Not all awards report bidder counts, and fewer bidders often means incumbent-held work rather than an easier win. Federal reporting of bidder counts fell from ~96% of awards (FY2016) to ~30% (FY2018 onward); the chart shows shares of reported awards, and washed-out stretches mark years with fewer than 30 of them.

Related NAICS Codes

Industries similar to Research and Development in Biotechnology (except Nanobiotechnology), by shared sector, subsector, and industry group.

Research and Development in Nanotechnology

This U.S. industry comprises establishments primarily engaged in conducting nanotechnology research ...
541713Same Industry GroupHigh Similarity

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

This U.S. industry comprises establishments primarily engaged in conducting research and experimenta...
541715Same Industry GroupHigh Similarity

Research and Development in the Social Sciences and Humanities

This industry comprises establishments primarily engaged in conducting research and analyses in cogn...
541720Same Industry GroupHigh Similarity

Offices of Lawyers

This industry comprises offices of legal practitioners known as lawyers or attorneys (i.e., counselo...
541110Same SubsectorMedium Similarity

Offices of Notaries

This industry comprises establishments (except offices of lawyers and attorneys) primarily engaged i...
541120Same SubsectorMedium Similarity

title Abstract and Settlement Offices

This U.S. industry comprises establishments (except offices of lawyers and attorneys) primarily enga...
541191Same SubsectorMedium Similarity

All Other Legal Services

This U.S. industry comprises establishments of legal practitioners (except offices of lawyers and at...
541199Same SubsectorMedium Similarity

Offices of Certified Public Accountants

This U.S. industry comprises establishments of accountants that are certified to audit the accountin...
541211Same SubsectorMedium Similarity

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NAICS 541714 FAQ

Frequently Asked Questions

NAICS code 541714 covers Research and Development in Biotechnology (except Nanobiotechnology). This U.S. industry comprises establishments primarily engaged in conducting biotechnology (except nanobiotechnology) research and experimental development. Biotechnology (except nanobiotechnology) research and experimental development involves the study of the use of microorganisms and cellular and biomolecular processes to develop or alter living or non-living materials. This research and development in biotechnology (except nanobiotechnology) may result in development of new biotechnology (except nanobiotechnology) processes or in prototypes of new or genetically-altered products that may be reproduced, utilized, or implemented by various industries. Illustrative Examples: Cloning research and experimental development laboratories DNA technologies (e.g., microarrays) research and experimental development laboratories Nucleic acid chemistry research and experimental development laboratories Protein engineering research and experimental development laboratories Recombinant DNA research and experimental development laboratories Cross-References. Establishments primarily engaged in--

Recently Posted in Research and Development in Biotechnology (except Nanobiotechnology)

NAICS: 541714
New
Federal
CUSTOM INDUCIBLE KNOCKIN MOUSE
Solicitation # PCA-NIDDK-02527
The National Institutes of Health intends to award a firm-fixed-price purchase order to Ingenious Targeting Laboratory Inc. for the creation of a custom inducible knockin mouse. This specific requirement involves an endogenous Gcm2 genomic modification, which distinguishes it from generic CRISPR/Cas9 mouse generation or services using heterologous promoters in a transgene. Based on market research, Ingenious Targeting Laboratory Inc. has been identified as the only responsible source capable of meeting these precise technical specifications. While this notice is not a request for competitive quotes, the government allows small businesses to submit written capability statements to demonstrate their ability to perform the requirement. Responses must be submitted to the primary point of contact by 9:00 a.m. EDT on September 1, 2026. If no other capable vendors are identified, the award is expected to be issued approximately five days after the notice date.
National Institutes Of Health Olao

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2 days ago

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NAICS: 541714
New
SBIR / STTR
Autonomous Navigation & Control Systems DevelopmentThe Defense Advanced Research Projects Agency under the U.S. Department of Defense is seeking a subcontract for the development of autonomous navigation and control systems. The project focuses on the design and simulation of navigation algorithms specifically for underwater vehicles operating in GPS-denied environments, utilizing a combination of acoustic, inertial, and environmental sensing technologies. This opportunity is designated as a Total Small Business Set-Aside under the SBIR/STTR mandate for companies with fewer than 500 employees, falling under NAICS code 541714. The solicitation was posted on August 26, 2026, with a response deadline of September 23, 2026.
Defense Advanced Research Projects Agency

POSTED

3 days ago

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in 25 days
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NAICS: 541714
New
Federal
AN41--Intent to Sole Source - Duke University MRI Service
Solicitation # 36C24626Q0986
The Department of Veterans Affairs Network Contracting Office 6, Durham VA Health Care System, intends to enter into a sole source procurement with Duke University for neuroimaging and data analytics services. This action falls under NAICS 541714 for Research and Development in Biotechnology and is being conducted under the authority of FAR 6.302-1 and FAR 12.102. Interested parties must submit their capabilities and interest to the designated contract specialist by 10:00 AM EST on August 31, 2026. The procurement strictly prohibits the use of gray market or remanufactured items, requiring all medical supplies, equipment, and maintenance services to be provided by an Original Equipment Manufacturer or an authorized dealer. Vendors must provide verification of their authorization to ensure that OEM warranties and services are maintained. Failure to comply with these requirements regarding gray market items will be considered a breach of contract, granting the government the right to terminate the agreement or require the replacement of non-compliant items at no cost.
246-NETWORK Contracting Office 6 (36C246)

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NAICS: 541714
New
SBIR / STTR
Universal Cell Culture Platform for Rapid Establishment of Species-Agnostic Cell Lines and Autonomous Culture Operations
Solicitation # DPA26BZ05-DV020
Defense Advanced Research Projects Agency

POSTED

3 days ago

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in 25 days
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NAICS: 541714
New
Federal
Preclinical Assessment of Naloxone Adequacy to Reverse Polysubstance Use-Induced Respiratory Depression — In Vivo Validation
Solicitation # 75F40126Q00382
The U.S. Food and Drug Administration is issuing a sole source, firm-fixed-price contract to Charles River Laboratories for a twelve month preclinical study. The research aims to evaluate the efficacy of naloxone and alternative reversal agents in treating respiratory depression caused by polysubstance use, specifically addressing the prevalence of fentanyl adulterated with xylazine, d-methamphetamine, or alprazolam. The study will utilize male CD rats to simultaneously measure respiratory and cardiovascular changes, as these systems are closely linked during drug-induced respiratory failure. The project consists of a four-phase in vivo study involving surgically instrumented animals. Key tasks include using whole body plethysmography for respiratory monitoring and implanted telemetry for continuous cardiovascular data collection. The contractor is responsible for collecting blood samples at five prespecified time points for pharmacokinetic analysis to be performed by the FDA. All work will be conducted in an AAALAC-accredited facility under non-GLP conditions, with statistical analysis performed via ANOVA.
FDA Office Of Acq Grant Svcs

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NAICS: 541714
New
Grant
Clinical Research with Human SubjectsThe Department of Defense, through the Defense Health Agency Contracting Activity, is seeking a subcontractor for the design and execution of clinical research involving human subjects or human biospecimens. The scope of work encompasses critical research operations, including ensuring IRB compliance, managing participant recruitment, overseeing data management, and maintaining strict adherence to PHS inclusion standards. This opportunity is categorized under NAICS code 541714 and was posted on August 26, 2026. Interested parties must submit their responses by the deadline of November 4, 2026.
Defense Health Agency Contracting Activity - Dhaca

POSTED

3 days ago

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in 2 months
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NAICS: 541714
New
SBIR / STTR
SBIR: UC-RAPID
Solicitation # DPA26BZ05-DV020
The SBIR UC-RAPID solicitation, issued by the Department of Defense Small Business Projects Office, seeks the development and demonstration of an automated, species-agnostic cell culture platform. This technology is intended to rapidly establish viable cell lines, including induced pluripotent stem cells, from a variety of non-model species to support the validation of genetic-biocontrol technologies. This opportunity is a total small business set-aside for companies with fewer than 500 employees. The solicitation was posted on August 26, 2026, with a response deadline of September 23, 2026.
Small Business Projects Office

POSTED

3 days ago

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in 25 days
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NAICS: 541714
New
Federal
Firefox Proposers Day
Solicitation # DARPA-SN-26-112
The Biological Technologies Office of DARPA is hosting an in-person Proposer Day on September 1, 2026, at the DARPA Conference Center in Arlington, Virginia, to support the upcoming Firefox Program solicitation. The event runs from 9:00 AM to 5:00 PM Eastern Daylight Time and is mandatory for attendance, with no virtual options available. Each organization is limited to three attendees, and advance registration is required with a deadline of August 21, 2026. The solicitation number is DARPA-SN-26-112, and it falls under NAICS code 541714, indicating research and development in the physical, engineering, and life sciences. Proposers are directed to contact Dr. Pedro Irazoqui at Firefox@darpa.mil for inquiries, and all times referenced in the announcement and registration materials are in Eastern Daylight Time.
Defense Advanced Research Projects Agcy

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4 days ago

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NAICS: 541714
New
Federal
Notice of Intent to Sole Source - Gut Microbiome DNA Sequencing Services
Solicitation # 1232SA26Q1371
The Department of Agriculture, specifically the USDA Ars Afm Apd, has issued a special notice of intent to sole source a contract for Gut Microbiome DNA Sequencing Services under solicitation number 1232SA26Q1371. This procurement falls under NAICS code 541714 and is not subject to any specific set-aside restrictions. The notice was posted on August 25, 2026, with a response deadline of September 1, 2026. The place of performance is located in Pennsylvania, and the primary point of contact for this opportunity is Frank Palmer.
USDA Ars Afm Apd

POSTED

4 days ago

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in 3 days
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NAICS: 541714
New
Federal
AN13--Intent to sole source - Miniaturized CO2 Sensor Prototype Development and Novel Physiologic Gas Monitoring Research
Solicitation # 36C24E26Q0110
The Department of Veterans Affairs RPO-E R&D intends to award a sole source Firm Fixed Price contract to the University of Michigan for the development of a miniaturized CO2 sensor prototype and research into novel physiologic gas monitoring. This notice serves as a public announcement of the intent to sole source under specific federal acquisition regulations and is not a request for proposals or quotations. Interested parties may submit capability information to demonstrate their ability to meet the requirements described in the statement of work by 10:00am EST on September 8, 2026. The government will review these submissions solely to determine if a competitive procurement is necessary. All inquiries and capability statements must be emailed to Contracting Officer Renee Kale, as telephone inquiries will not be accepted.
Rpo East (36C24E)

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NAICS: 541714
New
Federal
Hypobaric Chamber Pilot Studies
Solicitation # 80JSC026Q0006
NASA Johnson Space Center is soliciting offers for pilot chamber testing facilities capable of conducting hypobaric Decompression Sickness (DCS) studies under solicitation number 80JSC026Q0006, issued as a combined synopsis and solicitation per FAR Part 12 for commercial products and services. The requirement calls for three test days of data collection and recording following established research protocols, with detailed specifications outlined in Attachment A – Statement of Work and additional submission criteria in Attachment D dated July 15, 2026. The solicitation is open to all responsible sources without set-aside restrictions, and offerors must declare their size status under NAICS code 541714 with a 1,000-employee size standard. Evaluation of proposals will prioritize technical acceptability, followed by past performance, and then price, as specified in FAR 52.212-2. Offers must comply with applicable clauses including FAR 52.212-1, 52.212-2, and 52.212-4, as well as NASA-specific clauses such as the Ombudsman provision. All submissions must be delivered electronically to Tracy.L.Quintanilla@nasa.gov and Katelyn.R.Jaime@nasa.gov no later than August 24, 2026, at 1:00 p.m. Central Time. Questions must be submitted via email by July 29, 2026, same time, with no telephone inquiries accepted. Prospective offerors are encouraged to notify the point of contact of their intent to respond, and it is the offeror’s responsibility to download all documents from SAM.gov and ensure timely submission, as late or incomplete offers will be rejected in accordance with FAR provisions.
NASA Johnson Space Center

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5 days ago

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NAICS: 541714
New
SBIR / STTR
Export-Controlled Technology Development (ITAR/EAR Compliance)This subcontract opportunity with the U.S. Army under the Department of Defense focuses on research and development involving export-controlled technologies. The project requires strict adherence to ITAR and EAR regulations, specifically regarding the acquisition of necessary licenses and the proper disclosure of foreign nationals involved in the work. The opportunity is a total small business set-aside under NAICS code 541714, specifically mandated for SBIR/STTR participants with fewer than 500 employees. Interested parties must submit their responses by September 11, 2026, at 4:00 PM.
U.S. Army

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