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NAICS Code· 541714

NAICS 541714: Research and Development in Biotechnology (except Nanobiotechnology)

This U.S. industry comprises establishments primarily engaged in conducting biotechnology (except nanobiotechnology) research and experimental development. Biotechnology (except nanobiotechnology) research and experimental development involves the study of the use of microorganisms and cellular and biomolecular processes to develop or alter living or non-living materials. This research and development in biotechnology (except nanobiotechnology) may result in development of new biotechnology (except nanobiotechnology) processes or in prototypes of new or genetically-altered products that may be reproduced, utilized, or implemented by various industries. Illustrative Examples: Cloning research and experimental development laboratories DNA technologies (e.g., microarrays) research and experimental development laboratories Nucleic acid chemistry research and experimental development laboratories Protein engineering research and experimental development laboratories Recombinant DNA research and experimental development laboratories Cross-References. Establishments primarily engaged in--Show more

NAICS 541714 – Research and Development in Biotechnology (except Nanobiotechnology) encompasses scientific research and development activities focused on applying biological systems, organisms, or cellular processes to develop novel therapeutics, diagnostics, vaccines, and biomanufacturing platforms. This sector supports federal initiatives in precision medicine, infectious disease mitigation, biosecurity, and advanced bioprocessing, often involving recombinant DNA technology, protein engineering, cell line development, and high-throughput screening.

119
Active Contracts
$968.4M
Total Obligations (12mo)
422
Awarded Contracts (12mo)
290
Contractors Awarded (12mo)
1
Median Bidders per Award
-23.0%
YoY Growth

Contract Opportunities

Active solicitations and awarded contracts classified under NAICS 541714 — Research and Development in Biotechnology (except Nanobiotechnology).

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NAICS 541714 FAQ

Frequently Asked Questions

NAICS code 541714 covers Research and Development in Biotechnology (except Nanobiotechnology). This U.S. industry comprises establishments primarily engaged in conducting biotechnology (except nanobiotechnology) research and experimental development. Biotechnology (except nanobiotechnology) research and experimental development involves the study of the use of microorganisms and cellular and biomolecular processes to develop or alter living or non-living materials. This research and development in biotechnology (except nanobiotechnology) may result in development of new biotechnology (except nanobiotechnology) processes or in prototypes of new or genetically-altered products that may be reproduced, utilized, or implemented by various industries. Illustrative Examples: Cloning research and experimental development laboratories DNA technologies (e.g., microarrays) research and experimental development laboratories Nucleic acid chemistry research and experimental development laboratories Protein engineering research and experimental development laboratories Recombinant DNA research and experimental development laboratories Cross-References. Establishments primarily engaged in--

Recently Posted in Research and Development in Biotechnology (except Nanobiotechnology)

NAICS: 541714
New
Federal
CUSTOM INDUCIBLE KNOCKIN MOUSE
Solicitation # PCA-NIDDK-02527
The National Institutes of Health intends to award a firm-fixed-price purchase order to Ingenious Targeting Laboratory Inc. for the creation of a custom inducible knockin mouse. This specific requirement involves an endogenous Gcm2 genomic modification, which distinguishes it from generic CRISPR/Cas9 mouse generation or services using heterologous promoters in a transgene. Based on market research, Ingenious Targeting Laboratory Inc. has been identified as the only responsible source capable of meeting these precise technical specifications. While this notice is not a request for competitive quotes, the government allows small businesses to submit written capability statements to demonstrate their ability to perform the requirement. Responses must be submitted to the primary point of contact by 9:00 a.m. EDT on September 1, 2026. If no other capable vendors are identified, the award is expected to be issued approximately five days after the notice date.
National Institutes Of Health Olao

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2 days ago

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NAICS: 541714
New
SBIR / STTR
Autonomous Navigation & Control Systems DevelopmentThe Defense Advanced Research Projects Agency under the U.S. Department of Defense is seeking a subcontract for the development of autonomous navigation and control systems. The project focuses on the design and simulation of navigation algorithms specifically for underwater vehicles operating in GPS-denied environments, utilizing a combination of acoustic, inertial, and environmental sensing technologies. This opportunity is designated as a Total Small Business Set-Aside under the SBIR/STTR mandate for companies with fewer than 500 employees, falling under NAICS code 541714. The solicitation was posted on August 26, 2026, with a response deadline of September 23, 2026.
Defense Advanced Research Projects Agency

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3 days ago

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NAICS: 541714
New
Federal
AN41--Intent to Sole Source - Duke University MRI Service
Solicitation # 36C24626Q0986
The Department of Veterans Affairs Network Contracting Office 6, Durham VA Health Care System, intends to enter into a sole source procurement with Duke University for neuroimaging and data analytics services. This action falls under NAICS 541714 for Research and Development in Biotechnology and is being conducted under the authority of FAR 6.302-1 and FAR 12.102. Interested parties must submit their capabilities and interest to the designated contract specialist by 10:00 AM EST on August 31, 2026. The procurement strictly prohibits the use of gray market or remanufactured items, requiring all medical supplies, equipment, and maintenance services to be provided by an Original Equipment Manufacturer or an authorized dealer. Vendors must provide verification of their authorization to ensure that OEM warranties and services are maintained. Failure to comply with these requirements regarding gray market items will be considered a breach of contract, granting the government the right to terminate the agreement or require the replacement of non-compliant items at no cost.
246-NETWORK Contracting Office 6 (36C246)

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3 days ago

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NAICS: 541714
New
SBIR / STTR
Universal Cell Culture Platform for Rapid Establishment of Species-Agnostic Cell Lines and Autonomous Culture Operations
Solicitation # DPA26BZ05-DV020
Defense Advanced Research Projects Agency

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3 days ago

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NAICS: 541714
New
Federal
Preclinical Assessment of Naloxone Adequacy to Reverse Polysubstance Use-Induced Respiratory Depression — In Vivo Validation
Solicitation # 75F40126Q00382
The U.S. Food and Drug Administration is issuing a sole source, firm-fixed-price contract to Charles River Laboratories for a twelve month preclinical study. The research aims to evaluate the efficacy of naloxone and alternative reversal agents in treating respiratory depression caused by polysubstance use, specifically addressing the prevalence of fentanyl adulterated with xylazine, d-methamphetamine, or alprazolam. The study will utilize male CD rats to simultaneously measure respiratory and cardiovascular changes, as these systems are closely linked during drug-induced respiratory failure. The project consists of a four-phase in vivo study involving surgically instrumented animals. Key tasks include using whole body plethysmography for respiratory monitoring and implanted telemetry for continuous cardiovascular data collection. The contractor is responsible for collecting blood samples at five prespecified time points for pharmacokinetic analysis to be performed by the FDA. All work will be conducted in an AAALAC-accredited facility under non-GLP conditions, with statistical analysis performed via ANOVA.
FDA Office Of Acq Grant Svcs

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3 days ago

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NAICS: 541714
New
Grant
Clinical Research with Human SubjectsThe Department of Defense, through the Defense Health Agency Contracting Activity, is seeking a subcontractor for the design and execution of clinical research involving human subjects or human biospecimens. The scope of work encompasses critical research operations, including ensuring IRB compliance, managing participant recruitment, overseeing data management, and maintaining strict adherence to PHS inclusion standards. This opportunity is categorized under NAICS code 541714 and was posted on August 26, 2026. Interested parties must submit their responses by the deadline of November 4, 2026.
Defense Health Agency Contracting Activity - Dhaca

POSTED

3 days ago

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in 2 months
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NAICS: 541714
New
SBIR / STTR
SBIR: UC-RAPID
Solicitation # DPA26BZ05-DV020
The SBIR UC-RAPID solicitation, issued by the Department of Defense Small Business Projects Office, seeks the development and demonstration of an automated, species-agnostic cell culture platform. This technology is intended to rapidly establish viable cell lines, including induced pluripotent stem cells, from a variety of non-model species to support the validation of genetic-biocontrol technologies. This opportunity is a total small business set-aside for companies with fewer than 500 employees. The solicitation was posted on August 26, 2026, with a response deadline of September 23, 2026.
Small Business Projects Office

POSTED

3 days ago

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in 25 days
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NAICS: 541714
New
Federal
Firefox Proposers Day
Solicitation # DARPA-SN-26-112
The Biological Technologies Office of DARPA is hosting an in-person Proposer Day on September 1, 2026, at the DARPA Conference Center in Arlington, Virginia, to support the upcoming Firefox Program solicitation. The event runs from 9:00 AM to 5:00 PM Eastern Daylight Time and is mandatory for attendance, with no virtual options available. Each organization is limited to three attendees, and advance registration is required with a deadline of August 21, 2026. The solicitation number is DARPA-SN-26-112, and it falls under NAICS code 541714, indicating research and development in the physical, engineering, and life sciences. Proposers are directed to contact Dr. Pedro Irazoqui at Firefox@darpa.mil for inquiries, and all times referenced in the announcement and registration materials are in Eastern Daylight Time.
Defense Advanced Research Projects Agcy

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4 days ago

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NAICS: 541714
New
Federal
Notice of Intent to Sole Source - Gut Microbiome DNA Sequencing Services
Solicitation # 1232SA26Q1371
The Department of Agriculture, specifically the USDA Ars Afm Apd, has issued a special notice of intent to sole source a contract for Gut Microbiome DNA Sequencing Services under solicitation number 1232SA26Q1371. This procurement falls under NAICS code 541714 and is not subject to any specific set-aside restrictions. The notice was posted on August 25, 2026, with a response deadline of September 1, 2026. The place of performance is located in Pennsylvania, and the primary point of contact for this opportunity is Frank Palmer.
USDA Ars Afm Apd

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4 days ago

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NAICS: 541714
New
Federal
AN13--Intent to sole source - Miniaturized CO2 Sensor Prototype Development and Novel Physiologic Gas Monitoring Research
Solicitation # 36C24E26Q0110
The Department of Veterans Affairs RPO-E R&D intends to award a sole source Firm Fixed Price contract to the University of Michigan for the development of a miniaturized CO2 sensor prototype and research into novel physiologic gas monitoring. This notice serves as a public announcement of the intent to sole source under specific federal acquisition regulations and is not a request for proposals or quotations. Interested parties may submit capability information to demonstrate their ability to meet the requirements described in the statement of work by 10:00am EST on September 8, 2026. The government will review these submissions solely to determine if a competitive procurement is necessary. All inquiries and capability statements must be emailed to Contracting Officer Renee Kale, as telephone inquiries will not be accepted.
Rpo East (36C24E)

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5 days ago

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NAICS: 541714
New
Federal
Hypobaric Chamber Pilot Studies
Solicitation # 80JSC026Q0006
NASA Johnson Space Center is soliciting offers for pilot chamber testing facilities capable of conducting hypobaric Decompression Sickness (DCS) studies under solicitation number 80JSC026Q0006, issued as a combined synopsis and solicitation per FAR Part 12 for commercial products and services. The requirement calls for three test days of data collection and recording following established research protocols, with detailed specifications outlined in Attachment A – Statement of Work and additional submission criteria in Attachment D dated July 15, 2026. The solicitation is open to all responsible sources without set-aside restrictions, and offerors must declare their size status under NAICS code 541714 with a 1,000-employee size standard. Evaluation of proposals will prioritize technical acceptability, followed by past performance, and then price, as specified in FAR 52.212-2. Offers must comply with applicable clauses including FAR 52.212-1, 52.212-2, and 52.212-4, as well as NASA-specific clauses such as the Ombudsman provision. All submissions must be delivered electronically to Tracy.L.Quintanilla@nasa.gov and Katelyn.R.Jaime@nasa.gov no later than August 24, 2026, at 1:00 p.m. Central Time. Questions must be submitted via email by July 29, 2026, same time, with no telephone inquiries accepted. Prospective offerors are encouraged to notify the point of contact of their intent to respond, and it is the offeror’s responsibility to download all documents from SAM.gov and ensure timely submission, as late or incomplete offers will be rejected in accordance with FAR provisions.
NASA Johnson Space Center

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5 days ago

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in 12 days
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NAICS: 541714
New
SBIR / STTR
Export-Controlled Technology Development (ITAR/EAR Compliance)This subcontract opportunity with the U.S. Army under the Department of Defense focuses on research and development involving export-controlled technologies. The project requires strict adherence to ITAR and EAR regulations, specifically regarding the acquisition of necessary licenses and the proper disclosure of foreign nationals involved in the work. The opportunity is a total small business set-aside under NAICS code 541714, specifically mandated for SBIR/STTR participants with fewer than 500 employees. Interested parties must submit their responses by September 11, 2026, at 4:00 PM.
U.S. Army

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5 days ago

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