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RFI - Protection Before Day One Vaccine: Seasonal Influenza Vaccines with Pandemic Coverage

Closed

RFI-26-08-PBD1Federal

Submission Closed07/15/2026, 05:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541714

New

Federal

Request for Proposals (RFP) - BARDA Vaccine Medical Countermeasures for Pandemic Influenza Preparedness & Response

Solicitation # 75A50126R00001_RFP_NPIVS_27

BARDA is seeking contractors to support the Vaccine Medical Countermeasures for Pandemic Influenza Preparedness and Response Program. The selected providers will be responsible for furnishing all necessary personnel, materials, and facilities to produce vaccines, antigens, and adjuvants for pandemic preparedness and public health emergencies. This includes generating and submitting critical analytical, clinical, and manufacturing data to the FDA to ensure rapid regulatory decisions and manufacturing readiness. To be eligible for this award, offerors must have experience producing vaccines against influenza and strains with pandemic potential. Mandatory qualifications include either holding a U.S. influenza vaccine license or demonstrating the development of an influenza vaccine through the submission of a Biologics License Application for seasonal or pandemic vaccines. This solicitation is managed by the Department of Health and Human Services with a response deadline of October 30, 2026.

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Industry Day: DARPA Documentation & Decision Support Sprint (D2)

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Defense Advanced Research Projects Agcy

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DARPA Surgical Competition (DSC) Industry Day

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Defense Advanced Research Projects Agcy

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Human Hindbrain Organoid Functional Assay Services.

Solicitation # RFQ_CDR-2026-135968

The U.S. Food and Drug Administration, through the Center for Drug Evaluation and Research, intends to award a sole-source, firm-fixed-price purchase order to OrganoTherapeutics SARL for human iPSC-derived hindbrain organoid functional assay services. This acquisition, conducted under FAR Part 12 as a commercial service, aims to support in vitro research on drug-induced effects on respiratory-relevant neural circuits. The scope of work includes the provision of human hindbrain organoids and associated culture materials, with twelve scheduled deliveries to the FDA White Oak Campus in Silver Spring, Maryland. The first delivery will consist of 96 organoids, followed by eleven subsequent deliveries of 48 organoids each. The contractor will perform functional characterization at its own laboratory using three-dimensional multi-electrode array technology to assess electrophysiological responses to FDA-identified drug and reversal-agent combinations. Key deliverables include the raw and analyzed data, analysis files, and comprehensive study reports. The anticipated period of performance is 18 months from the date of award. Award will be based on best value, with technical capability and past performance weighted more heavily than price. All invoicing must be processed electronically through the U.S. Department of Treasury's Invoice Processing Platform.

FDA Office Of Acq Grant Svcs

POSTED

DEADLINE

Hypoxia Chamber Services

Solicitation # 80JSC026Q0008

NASA Johnson Space Center is soliciting combined synopsis and request for quotations under solicitation 80JSC026Q0008 for Hypoxia Chamber Services to support the Artemis Program. The objective is to investigate the physiological, cognitive, and clinical effects of mild hypobaric hypoxia through two 7-day test protocols involving continuous habitation for six subjects at air equivalent altitudes of 7,000 and 9,500 feet. The scope of work encompasses the provision of infrastructure, personnel, training, materials, and operational support. The contract is structured as a firm fixed price agreement with a base period from September 15, 2026, to September 30, 2027, and multiple option periods extending through March 1, 2030. The acquisition is open to all responsible sources under NAICS code 541714, with a size standard of 1,000 employees. Evaluation is based on a trade-off process where technical acceptability and past performance are significantly more important than price. Proposals must be submitted via email to the designated points of contact by October 1, 2026, following an extension granted in Amendment 0004. Key requirements include the submission of FAR 52.212-3 representations and certifications and adherence to specific submission criteria regarding team qualifications and risk assessment. The contract also incorporates strict guidelines regarding the protection of sensitive information and restrictions on funding activities with China.

NASA Johnson Space Center

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Hypobaric Chamber Pilot Studies

Solicitation # 80JSC026Q0006

NASA Johnson Space Center is soliciting quotes under solicitation 80JSC026Q0006 for pilot hypobaric chamber testing facilities to support decompression sickness research. The primary objective is to validate non-NASA resources for safe prebreathe procedures and extravehicular activity to support Artemis mission planning. The base requirement consists of three test days, with a minimum of two subjects per day, collecting and recording data according to research protocols. The contract also includes six optional work items, including additional test days, inflight-like treatment preparation, elevated metabolic rate testing, pharmaceutical-enhanced prebreathe, and body temperature studies. The base period of performance runs from September 1, 2026, to September 30, 2027, with various option periods extending through March or September 2029. This is a small business set-aside acquisition under NAICS code 541714. Awards will be made based on a trade-off analysis where technical acceptability and past performance are significantly more important than price. Technical evaluation focuses on facility capabilities, medical support, team expertise, and the proposed schedule for subject throughput. Offerors must provide a price quotation using the provided pricing sheet, and quotes must remain valid for at least 90 days. Following several amendments, the final deadline for the submission of offers is October 1, 2026, at 1:00 p.m. Central Time. All submissions must be sent electronically to the designated points of contact.

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study entitled “Malaria and vector borne disease surveillance in the Colombia/Venezuela border”

Solicitation # ERP_1301373256

The Naval Medical Research Unit South in Lima, Peru, is seeking a provider to conduct a study focused on malaria and vector borne disease surveillance along the Colombia and Venezuela border. While the government has identified the Administrators of Tulane Educational Fund as the only vendor currently capable of supporting the entire requirement, they are issuing this notice to identify other capable sources before proceeding with a sole source award under FAR 13.106-1(b)(i). Interested parties must submit a capability statement including technical, management, and cost data to Genaro Vasquez via email by 12:00 PM local time on September 18, 2026. Submissions must be in Microsoft Word or PDF format, not exceed five pages, and use the subject line ERP_1301373256. The government will use these submissions to determine whether to pursue a competitive procurement or move forward with the intended sole source contract.

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National Institutes Of Health Olao

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DEADLINE

TIDAL: Target-Induced Droplet Assembly of Ligands

Solicitation # S-197478

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Triad - DOE Contractor

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Master Protocol Development & Adaptive Design

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Phase I/II Clinical Trial Management & Execution

W6QK Acc-Apg

POSTED

8 days ago

DEADLINE

in 5 days

AI Contract Overview

The Center for Biomedical Advanced Research and Development Authority (BARDA) is seeking information on vaccine candidates designed to provide dual protection against seasonal influenza and emerging pandemic influenza strains, referred to as “Day One vaccines.” These vaccines aim to bridge the critical three-month gap between the emergence of a novel pandemic strain and the availability of strain-matched vaccines, offering immediate, albeit partial, immunity to reduce infection rates, hospitalizations, and peak transmission during the earliest phase of a public health emergency. The desired profile includes seasonal flu protection alongside cross-reactive immunity against high-priority avian subtypes such as H2, H5, H7, and H9, with minimal requirements including at least a 10% reduction in pandemic infections and 30% reduction in hospitalizations, while ideal characteristics involve broader coverage across all influenza A subtypes, multiyear durability, room-temperature stability, and safety comparable to current seasonal vaccines. Responses are sought from organizations capable of demonstrating technical maturity in vaccine design, nonclinical and clinical data supporting efficacy and immunogenicity against both seasonal and pandemic strains, readiness in manufacturing and CMC processes, and a clear regulatory strategy aligned with FDA pathways. This Request for Information (RFI-26-08-PBD1), posted on June 3, 2026 and due by July 15, 2026, is strictly a market research tool with no intent to award a contract or provide compensation for submissions. Respondents must submit a single PDF document not exceeding ten pages, with strict section limits outlined for executive summary, organizational overview, vaccine candidate details, nonclinical and manufacturing data, clinical strategy, and regulatory considerations. The submission must be emailed to rrpv@ati.org by the deadline, with no other formats or attachments permitted. While no formal contract clauses or payment terms are included, respondents are required to self-identify as small or other-than-small businesses under NAICS code 541714, and submissions must be clearly marked for confidentiality if they contain proprietary information. All information provided may be reviewed by non-federal personnel under NDA, and future awards may require membership in the RRPV consortium. The primary performance location is Washington, DC, and any subsequent procurement will evaluate technical superiority over cost, prioritizing innovation, breadth of protection, manufacturability, and public health impact to enable rapid deployment of a vaccine that offers meaningful protection from Day One of a pandemic.

General Info

Seeking development of immediate, dual-benefit influenza vaccines to bridge early pandemic protection gap.

Agency

Department Of Health And Human Services → Barda - Aspr / Daappo / Barda DcmaView Agency

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)View NAICS

Place of Performance

Washington, DC, 20024, USA

Set-Aside

NONE

Documents

(1)

RFI-26-08-PBD1 Protection Before Day One Vaccine RFI

DOCX•rfi

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseClosed

PostedJun 3

Sources Sought

Response DeadlineJul 15

Deadline has passed

Submission Closed

07/15/2026, 05:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → Barda - Aspr / Daappo / Barda Dcma

Contacts1 person available

OfficeWASHINGTON, DC, 20515, USA

Organization / Agency

Department Of Health And Human Services → Barda - Aspr / Daappo / Barda Dcma

View Agency Profile

Office AddressWASHINGTON, DC, 20515, USA

Contacts

Wendy Rehman

contact@example.gov

Full Description

“Protection Before Day One Vaccine: Seasonal Influenza Vaccines with Pandemic Coverage”

Request for Information (RFI)

1.0 Background

Influenza viruses remain a persistent and evolving threat to public health in the United States and globally. Seasonal influenza epidemics cause significant morbidity and mortality each year, while novel zoonotic influenza subtypes retain the potential to trigger pandemics. A critical vulnerability in current pandemic preparedness is the time required—typically at least three months—between identification of a novel pandemic strain and deployment of strain-matched vaccines at scale.

The Center for the Biomedical Advanced Research and Development Authority (BARDA) has led efforts to develop improved influenza vaccines and expand domestic manufacturing capacity, including initiatives to accelerate vaccine development timelines. However, limitations in current vaccine technologies result in a protection gap during the earliest phase of a pandemic.

In a pandemic setting, early intervention is crucial to dampening the spread and impact of a novel virus. Prior modeling studies have demonstrated that a modestly effective but rapidly distributed vaccine can provide a greater benefit than a highly efficacious but delayed vaccine. Similarly, bolstering population immunity before a pandemic would lessen the damage caused by emergent influenza strains, even if the vaccine is only partially protective. BARDA refers to these vaccines as offering “Protection Before Day One”, with “Day One vaccines” providing some degree of protection at the outset of a pandemic. Day One vaccines, would:

Deliver seasonal influenza protection; and
Provide partial protection against emerging pandemic influenza viruses at the onset of a Public Health Emergency.

Modeling suggests that Day One vaccines can not only reduce the total number of infections and peak infection rate but also delay the peak to allow more time for strain-matched pandemic vaccines to become available. In addition to the population-level benefits, Day One vaccines would also benefit individual vaccine recipients by reducing the risk of severe disease. Even with modest effectiveness, receiving a Day One vaccine could reduce an individual’s hospitalization risk by 35%.

Through this RFI, BARDA seeks to understand the availability of candidate Day One vaccines, including their development maturity, technical feasibility, manufacturing readiness, and regulatory considerations associated with vaccine candidates intended to meet this dual-benefit profile.

Please see full Request for Information attached.