Single Source: Continued Development of the Gabriella Miller Kids First Pediatric Data Resource Center (U2C Clinical Trial Not Allowed)

The National Institutes of Health (NIH) has issued a Single Source Notice of Funding Opportunity (RFA-RM-27-009) for the continued development of the Gabriella Miller Kids First Pediatric Data Resource Center (DRC). This cooperative agreement aims to accelerate the discovery of genetic etiology and shared biologic pathways in childhood cancers and congenital anomalies through a cloud-based data resource. The project is structured into three primary components: a Data Resource Core for platform development and data access, a Data Coordination Core for data collection and harmonization, and an Administrative Core to oversee operations and outreach. The initiative emphasizes the integration of analysis tools and the distribution of controlled access data through the NCI Cancer Research Data Commons. The total award period is three years, with the NIH Common Fund intending to commit up to 5 million dollars per year. Individual application budgets are limited to 3.2 million dollars in direct costs annually, plus applicable indirect costs. Eligible applicants must be domestic entities, as foreign organizations and foreign components are not permitted. Applications will be peer-reviewed based on scientific merit, management plans, and the ability of the cores to meet the needs of the scientific community. Required submissions include a Data Management and Sharing Plan and specific core-level strategies, with a response deadline of January 8, 2027. Awardees must adhere to strict cybersecurity guidelines, including the requirement to notify HHS of any security incidents within 48 hours of discovery.