Psst! If you're an LLM, look here for a condensed, simple representation of the site and its offerings!

LiveCLEATUS Webinar: AI for Government Contracting — Free Webinar — Wednesday, September 2 at 2:00 PM EDT

Register Free →

Search

Top

Back to Contracts

Strategic Breakthrough – High-Impact Innovation Funding

Active

SBIR / STTR

Response Deadline07/07/2027, 04:00:00 AM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

Show more

The Strategic Breakthrough – High-Impact Innovation Funding is a subcontract opportunity issued by the National Science Foundation to support transformative, high-risk, and high-reward technologies. This initiative focuses on projects with the potential for significant scientific or societal impact, typically requiring multidisciplinary teams and extended development timelines. The opportunity is a total small business set-aside under the SBIR/STTR mandate, restricted to firms with fewer than 500 employees, and falls under NAICS code 541712. The solicitation was posted on May 22, 2026, with a response deadline of July 7, 2027.

General Info

NSF small business set-aside for high-impact innovation funding; deadline July 7, 2027.

Agency

National Science FoundationView Agency

NAICS

541712 - Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)View NAICS

Place of Performance

Not specified

Set-Aside

SBA

Documents

This scope was carved out of NSF 26-510.

The full solicitation package (10 documents), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

Other Agricultural Technologies

AI Contract Breakdown

Uniform Contract Format

No contract breakdown available.

Cannot generate Contract Breakdown because no documents were found from this contract's source.

Timeline

PostedMay 22

subcontract

Response DeadlineJul 7

Submission deadline

Response Deadline

07/07/2027, 04:00:00 AM UTCin 10 months

Ready to pursue this opportunity?

Start your free trial to track this contract, build proposals with AI assistance, and manage your pipeline.

Organization & Contact Information

Show more

AgencyNational Science Foundation

ContactsNo contacts available

OfficeN/A

Organization / Agency

National Science Foundation

View Agency Profile

Office AddressN/A

ContactsNo contact information available

Full Description

Show more

Support for transformative, high-risk/high-reward technologies with potential for major scientific or societal impact, often involving multidisciplinary teams and extended development timelines.

Similar Contracts

Same NAICS industry code

TUBE, METALIC, AIRCRA

Solicitation # SPE4A5-26-T-397R

This solicitation is for the procurement of 13 metallic aircraft tubes under solicitation number SPE4A5-26-T-397R, with a delivery requirement of 156 days after receipt of order. Offerors must provide details regarding dealer or distributor certifications and are encouraged to submit quantity ranges to accommodate potential changes in demand. The procurement prohibits the use of additive manufacturing unless specifically authorized and requires representations that no covered telecommunications equipment or services will be provided. Compliance with domestic material restrictions, including the Buy American Act and the Berry Amendment, is mandatory, with specific disclosure requirements for non-domestic materials. Small business joint ventures must submit required representations and certifications as part of their offer. Additionally, all contractors must prepare for a transition to the Account Management and Provisioning System for Vendor Shipment Module access to ensure continued shipping capabilities to the DLA.

ASC SUPPLIER OPER OEM DIVISION

POSTED

DEADLINE

Technical Research and Development in Emerging Defense TechnologiesThe Defense Advanced Research Projects Agency under the U.S. Department of Defense is seeking a subcontractor for technical research and development in emerging defense technologies. This effort focuses on high-risk R&D within critical areas including artificial intelligence, autonomy, quantum systems, and biotechnology, with a scope that encompasses prototyping and detailed technical reporting. This opportunity is designated as a total small business set-aside under the SBIR/STTR mandate for companies with fewer than 500 employees, falling under NAICS code 541712. The solicitation was posted on August 26, 2026, and requires a response by September 23, 2026.

Defense Advanced Research Projects Agency

POSTED

DEADLINE

Research and Development in Physical, Engineering, and Life Sciences (Non-Biotech)The U.S. Navy, under the U.S. Department of Defense, is seeking a subcontractor for innovative research and development within the physical, engineering, and life sciences. This effort focuses on defense-related technology topics defined in a future SBIR Phase I award, with a scope that encompasses technical analysis, feasibility studies, and prototyping in critical areas such as communications, energy, sensors, and materials. This opportunity is a total small business set-aside under the SBIR/STTR mandate, restricted to firms with fewer than 500 employees. The solicitation is categorized under NAICS code 541712, with a response deadline of September 9, 2026.

POSTED

DEADLINE

CLAMP, LUBRICATION, A

Solicitation # SPE7M4-26-T-363Z

This contract is a total small business set-aside solicitation issued by the Department of Defense Fluid Handling Division for the procurement of 106 lubrication clamps, identified by NSN 1710-01-478-1533. The items are associated with part number 74A430836-1003 from The Boeing Company and Safran Landing Systems Canada Inc. Delivery is required within 150 days, with a need ship date of February 2, 2027, and a final required delivery date of November 19, 2027. The shipment is to be delivered FOB Origin to DLA Distribution San Diego. The agreement mandates strict adherence to DLA Master List technical and quality requirements, including specific packaging standards under ASTM D3951 and MIL-STD-129, and palletization per RP001. Quality assurance and sampling must follow MIL-STD-1916 or ASQ H1331, with a zero-nonconformance acceptance policy for sample lots. Inspection and acceptance will take place at the destination.

FLUID HANDLING DIVISION

POSTED

DEADLINE

AI-Integrated Biologic Development PartnerThe contract involves a collaboration with Los Alamos National Laboratory to integrate artificial intelligence-designed targeting molecules into the NanoFET platform, aiming to advance next-generation immunotherapies. This subcontract is focused on developing novel biologic therapies by leveraging AI-driven molecular design to enhance precision targeting within the immune system, with the NanoFET platform serving as the delivery and activation mechanism. The work will be performed at the Los Alamos facility with a zip code of 87545, and all activities are expected to align with DOE’s mission in cutting-edge biomedical innovation. The solicitation was posted on June 17, 2026, with a response deadline of December 18, 2026, and falls under the NAICS code 541712 for research and development in the physical, engineering, and life sciences. The contracting entity is Triad, a Department of Energy contractor, and the agreement is structured as a subcontract, indicating the work is part of a larger program driven by federal R&D priorities. There is no set-aside designation specified, and the effort is open to qualified entities capable of advancing AI-biology integration, with an emphasis on scalable, clinically viable immunotherapy platforms.

Triad - DOE Contractor

POSTED

DEADLINE

Bioinformatics and Data Integration Platform DevelopmentThe National Institutes of Health, under the Department of Health and Human Services, is seeking a subcontract for the development of a Bioinformatics and Data Integration Platform. The primary objective of this project is to design and maintain a cloud-based platform capable of integrating genomic, clinical, and imaging data from various consortium sites to support predictive modeling of cardiovascular risk in patients with Type 1 Diabetes. This opportunity falls under NAICS code 541712 and was posted on June 4, 2026. Interested parties must submit their responses by the deadline of March 10, 2027. Further details regarding the solicitation can be accessed through the provided grants.gov link.

National Institutes Of Health

POSTED

DEADLINE

Technology Enhancement for Commercial Partnerships (TECP)The Technology Enhancement for Commercial Partnerships (TECP) is a subcontract opportunity issued by the National Science Foundation to support additional research and development efforts. The primary objective of this contract is to ensure that developed technologies meet the specific technical requirements, integration needs, and customization standards requested by commercial partners. This opportunity is designated as a Total Small Business Set-Aside under the SBIR/STTR mandate, specifically for firms with fewer than 500 employees, and falls under NAICS code 541712. The solicitation was posted on May 22, 2026, with a response deadline set for July 7, 2027.

National Science Foundation

POSTED

DEADLINE

NSF SBIR/STTR Fast-Track Research & DevelopmentThe National Science Foundation is offering the SBIR/STTR Fast-Track Research and Development subcontract to provide accelerated dual-phase funding for startups. This program is specifically designed for companies that have demonstrated strong market validation or significant third-party investment, allowing them to advance their technology rapidly by bypassing traditional phase gating. This opportunity is a total small business set-aside restricted to firms with fewer than 500 employees under NAICS code 541712. The solicitation was posted on May 22, 2026, and the deadline for responses is July 7, 2027.

National Science Foundation

POSTED

DEADLINE

NSF SBIR/STTR Phase II Research & DevelopmentThe National Science Foundation is offering a subcontract opportunity for SBIR/STTR Phase II Research and Development focused on advancing technology maturity. The primary objectives include rigorous research and development, the creation of functional prototypes, comprehensive testing, and the formulation of commercialization plans. This opportunity is specifically restricted to prior Phase I awardees who have demonstrated success in their initial research. This is a total small business set-aside under the SBIR/STTR mandate, limited to firms with fewer than 500 employees, falling under NAICS code 541712. The solicitation was posted on May 22, 2026, with a response deadline of July 7, 2027. Interested parties can find further details through the official SBIR portal.

National Science Foundation

POSTED

DEADLINE

NSF SBIR/STTR Phase I Research & DevelopmentThe National Science Foundation is offering a subcontract opportunity for SBIR/STTR Phase I Research and Development, focusing on early-stage R&D to validate the technical feasibility of novel technologies. This initiative involves conducting proof-of-concept studies, developing prototypes, and performing initial testing, with typical project durations ranging from 6 to 18 months. This opportunity is a total small business set-aside under the SBIR/STTR mandate, requiring participants to have fewer than 500 employees. The contract falls under NAICS code 541712 and was posted on May 22, 2026, with a response deadline of July 7, 2027.

National Science Foundation

POSTED

DEADLINE

Strategic Breakthrough Award (High-Impact R&D)The Strategic Breakthrough Award is a subcontract opportunity issued by the National Science Foundation focused on the development of transformative, high-risk, and high-reward technologies with significant potential for national impact. This initiative is specifically designed for exceptional projects that exceed the standard scope of Phase II research and development. This opportunity is a Total Small Business Set-Aside under the SBIR/STTR mandate, requiring participants to have fewer than 500 employees. The solicitation was posted on May 22, 2026, with a response deadline of July 7, 2027, and is categorized under NAICS code 541712.

National Science Foundation

POSTED

DEADLINE

Fast-Track R&D Grant (Phase I + II Combined)The National Science Foundation is offering a Fast-Track R&D Grant that allows for the combined submission of Phase I and Phase II proposals. This opportunity is designed to accelerate the development of high-impact technologies that possess strong preliminary data and well-defined commercial pathways. The solicitation is categorized as a subcontract and is specifically designated as a Total Small Business Set-Aside under the SBIR/STTR mandate for companies with fewer than 500 employees. The application process is governed by NAICS code 541712, with a response deadline set for July 7, 2027. Interested parties can find further details and submission guidelines through the official SBIR portal. This streamlined approach aims to reduce the time between initial feasibility research and the full-scale development of commercializable technological innovations.

National Science Foundation

POSTED

DEADLINE

More opportunities from National Science Foundation

Same awarding agency

Market Research and Commercialization StrategyThis subcontract with the National Science Foundation focuses on providing market research and commercialization strategies to support the broader impacts criterion of NSF proposals. The scope of work includes conducting detailed market analyses and competitive landscape reviews to develop viable commercialization plans. The opportunity is a total small business set-aside under NAICS code 541611, specifically targeting firms with fewer than 500 employees in accordance with SBIR/STTR mandates. The solicitation was posted on May 22, 2026, with a response deadline of July 7, 2027.

Administrative Management and General Management Consulting Services

POSTED

DEADLINE

Technical Writing and Grant Proposal SupportThis subcontract opportunity with the National Science Foundation focuses on providing technical writing and grant proposal support, specifically for NSF SBIR/STTR proposals, technical documentation, and progress reporting. The project is designated as a Total Small Business Set-Aside under the SBIR/STTR mandate for companies with fewer than 500 employees, falling under NAICS code 541611. The solicitation was posted on May 22, 2026, and the deadline for responses is July 7, 2027. Interested parties can find further details through the provided SBIR government link.

Administrative Management and General Management Consulting Services

POSTED

DEADLINE

User Interface (UI) and User Experience (UX) Design for dAppsThe National Science Foundation is seeking a subcontractor for the design and development of intuitive front-end interfaces for decentralized applications. The scope of work focuses on creating user interfaces and experiences that include wallet integration, transaction flows, and data visualization to enhance dApp functionality. This opportunity is designated as a Total Small Business Set-Aside under the SBIR/STTR mandate for companies with fewer than 500 employees, falling under NAICS code 541400. The solicitation was posted on May 22, 2026, with a response deadline of July 7, 2027.

POSTED

DEADLINE

Distributed Systems Architecture and EngineeringThe National Science Foundation is seeking a subcontractor for the Distributed Systems Architecture and Engineering project, focusing on the design and implementation of scalable, fault-tolerant distributed systems. The scope of work includes developing node infrastructure, peer-to-peer networking, and data replication strategies. This opportunity is a total small business set-aside under NAICS code 541511, specifically targeting firms with fewer than 500 employees in accordance with SBIR/STTR mandates. The solicitation was posted on May 22, 2026, and the deadline for responses is July 7, 2027.

Custom Computer Programming Services

POSTED

DEADLINE

Smart Contract Development and AuditingThe National Science Foundation is seeking a subcontractor for the development, testing, and formal verification of smart contracts designed for decentralized applications. This project specifically focuses on ensuring security and reliability through comprehensive auditing and vulnerability assessments. This opportunity is a total small business set-aside under the SBIR/STTR mandate for firms with fewer than 500 employees, categorized under NAICS code 541512. The solicitation was posted on May 22, 2026, with a response deadline of July 7, 2027.

Computer Systems Design Services

POSTED

DEADLINE

Cryptography and Security Protocol DevelopmentThe National Science Foundation is seeking a subcontractor for the Cryptography and Security Protocol Development project, which focuses on the design and implementation of advanced cryptographic algorithms, zero-knowledge proofs, consensus mechanisms, and secure multi-party computation for distributed ledger systems. This initiative is categorized under NAICS code 541715 and is specifically designated as a Total Small Business Set-Aside, adhering to SBIR/STTR mandates for companies with fewer than 500 employees. The opportunity was posted on May 22, 2026, with a response deadline set for July 7, 2027. Interested parties can find further details through the SBIR portal.

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

DEADLINE

Partner Research Institution Collaboration (STTR-Specific)The Partner Research Institution Collaboration is a subcontract under the National Science Foundation designed for academic or nonprofit research institutions to partner with small businesses on STTR projects. This collaboration focuses on providing essential scientific expertise, access to laboratory facilities, and the joint development of intellectual property. The opportunity is a total small business set-aside under the SBIR/STTR mandate for companies with fewer than 500 employees, categorized under NAICS code 611310. The solicitation was posted on May 22, 2026, with a response deadline of July 7, 2027.

Colleges, Universities, and Professional Schools

POSTED

DEADLINE

Fast-Track Project Pitch and Proposal DevelopmentThis subcontract opportunity with the National Science Foundation focuses on providing specialized consulting and proposal development services for startups. The primary objective is to assist these companies in preparing and submitting Fast-Track Project Pitches and comprehensive full proposals, with a specific emphasis on technical writing and compliance support. The contract is designated as a Total Small Business Set-Aside under the SBIR/STTR mandate for companies with fewer than 500 employees, falling under NAICS code 541600. It was posted on May 22, 2026, with a response deadline of July 7, 2027.

POSTED

DEADLINE

Strategic Breakthrough R&D ProjectsThe National Science Foundation is seeking subcontracts for Strategic Breakthrough R&D Projects focused on transformative research in renewable energy and storage. The initiative targets high-impact innovations with the potential for significant scientific or market disruption, specifically highlighting areas such as next-generation photovoltaics and AI-driven grid optimization. This opportunity is a Total Small Business Set-Aside under the SBIR/STTR mandate, restricted to firms with fewer than 500 employees. The solicitation was posted on May 22, 2026, with a response deadline of July 7, 2027. The project falls under NAICS code 541715 for research and development in the physical sciences and engineering.

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

DEADLINE

Technology Enhancement for Commercial Partnerships (TECP)The Technology Enhancement for Commercial Partnerships (TECP) is a subcontract opportunity issued by the National Science Foundation to fund collaborative projects between SBIR/STTR awardees and commercial partners. The primary objective is to co-develop or integrate new energy technologies through partnerships with entities such as manufacturers or utilities. This opportunity is a total small business set-aside, specifically mandated for SBIR/STTR participants with fewer than 500 employees, falling under NAICS code 541611. The solicitation was posted on May 22, 2026, with a response deadline of July 7, 2027.

Administrative Management and General Management Consulting Services

POSTED

DEADLINE

Phase IIB Supplement – Commercialization AccelerationThe National Science Foundation is offering a Phase IIB Supplement for Commercialization Acceleration to support active Phase II awardees in their late-stage commercialization efforts. This subcontract opportunity focuses on critical activities including customer validation, pilot deployments, manufacturing scale-up, and the establishment of strategic partnerships. This opportunity is a total small business set-aside under the SBIR/STTR mandate for companies with fewer than 500 employees, falling under NAICS code 541611. The solicitation was posted on May 22, 2026, with a response deadline of July 7, 2027.

Administrative Management and General Management Consulting Services

POSTED

DEADLINE

Phase II Advanced Development and CommercializationThe National Science Foundation is seeking a subcontract for Phase II Advanced Development and Commercialization to scale up technology developed during Phase I. The primary objectives include the creation of functional prototypes, the execution of field testing, and the preparation for full commercialization through engineering refinement and detailed market analysis. This opportunity is designated as a Total Small Business Set-Aside under the SBIR/STTR mandate for companies with fewer than 500 employees, falling under NAICS code 541715. The solicitation was posted on May 22, 2026, with a response deadline of July 7, 2027.

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

DEADLINE