Versatile Bioadhesives

The contract under the title Versatile Bioadhesives, issued by ARPA-H under solicitation number ARPA-H 02, seeks to advance the development of next-generation bioadhesive platforms capable of functioning effectively in clinically challenging environments such as wet, bloody, and dynamically moving tissues. These adhesives must provide robust sealing and bonding across a broad spectrum of tissues and organs while ensuring biocompatibility, controlled degradation, and the potential for reversibility. The technology must support critical applications including hemostasis, prevention of leaks, tissue repair, and fixation of medical devices, with the added capability to deliver biologics or small molecules as part of therapeutic intervention. Successful outcomes will yield deployable solutions that reduce surgical complications and enhance patient outcomes in diverse care settings. This opportunity is designated as a Total Small Business Set-Aside under the SBIR/STTR mandate, exclusively available to small businesses with fewer than 500 employees. It falls under NAICS code 325520, indicating its focus on pharmaceutical and medicinal chemical manufacturing, and is administered by the Department of Health and Human Services through ARPA-H. The solicitation was posted on June 11, 2026, with a response deadline of September 30, 2027. There is no specified place of performance or point of contact listed, and all applications must be submitted through the designated UI link. The emphasis is on translating innovative materials science into safe, reliable, and scalable medical technologies with transformative potential across multiple clinical domains.