36--PDS Small Volume System

Reaction Calorimeter with the following specifications: (1) The reaction calorimeter must use liquid phase heat flow calorimetry for process optimization, safety and scale up studies. (2) The system must have fully independent control of all reaction variables such as heating, cooling, stirring, dosing, pH. (3) The system must be capable of measuring the heat flow of a reaction during a temperature ramp. (4) The coolant circulation in the reactor jacket in excess of 50 liters per minute. (5) Ensure high precision calorimetry. (6) The system must be capable of performing real-time calorimetry allowing differentiation of total heat flow into increments. (7) The real time calorimetry measurement must be based on heat flux sensors in the reactor jacket. These sensors should be able to detect the heat flux across the reactor wall in real time. (8) The system must be able to combine real time calorimetry and heat flow principles of measurement. (9) The system must be able to perform isothermal (glass and metal), isoperibolic (glass and metal) and adiabatic (glass) reactions. (10) The system must be able to interchange reactors of different material construction, volume and pressure rating. This is a key to our ability to scale up a variety of wet chemical reactions. (11) The calorimeter must be heated and cooled by a built in thermostat rather than an auxiliary cryostat. (12) The system must have a dynamic heat/cool system. (13) To include a reservoir of cold oil available for immediate cooling in the case of a very exothermic reaction or an emergency cool down. (14) The system must have an engineered jacket flow pattern of oil around the reactor. (15) The system must have a two level safety system in which the intrinsic safety equipment monitors oil flow, oil level, and all electronics. In addition, the mass reaction temperature and jacket wall temperature including circuitry, must be backed up with redundant control systems and user definable maximum and minimum values for all measured values can be used to activate an emergency program. (16) A variety types of stirrers must be available, such as anchor, propeller, gassing, helical ribbon, propeller turbine, catalyst basket etc. (17) Control and safety must be an integral part of the instrument, not the host PC. (18) Dosing controllers must be microprocessor controlled. Each controller must have local control over dosing loops, pressure and pH control. (19) System must have full safety concept embedded. That is to say, should anything go wrong, safety is already in place, regardless of events elsewhere in the system. (20) In case of an emergency, the cooling capacity of the system must be in excess of 6KW. (21) The particle analyzer probe must provide in-process particle characterization in real time. (22) The particle analyzer must be measure particle size with no assumption of particle shape. (23) The particle analyzer must be easily integrated into the reaction calorimeter system.