1 Department of Veterans Affairs Office of Research & Development ORD Service Identification of secreted endothelial cell proteins Performance Work Statement (PWS) 1. Title: Micro-CT scan of the brain vasculature of blast-exposed rodents. 2. Purpose: Using micro-CT scan analyses identify morphological changes in the vasculature of blast-exposed rodents. 3. Background: In previous published research we have described cerebral vascular degenerative processes that develop as a consequence of blast injury. In collaboration with scientists at Micro Photonics we were able to visualize the late cerebral vascular attenuation at 10 months post-blast. 4. Scope: To observe the development of cerebral vascular degenerative processes over time in animal models of blast-induced traumatic brain injury 5. Period of Performance: September 9, 2019-September 8, 2020 6. Place of Performance: Due to the need for technical consistency, we suggest these analyses should be performed by the company that performed the original analyses, Micro Photonics, 1550 Pond Rd, Suite 110, Allentown, PA 18104 Tel.
+1 (555) 000-0000 7. Tasks 7.1 Task 1: Project Management and Progress Reporting 7.1.1 VA scientists will be responsible for the rodent blast exposures, intracardiac perfusion of the BriteVu contrasting agent, tissue fixation and shipment of the fixed brains to the contractor, Micro Photonics, Inc who will perform the high resolution micro CT-scan analyses of the brain vasculature. 7.2 Task 2: Data Collection and Reporting The contractor should generate data for 3D-reconstruction imaging and for quantitative analyses of the vasculature including length, volume and area. 7.3 Task 3: Simple and Complex Data Analyses Data analyses will be performed by VA scientists at the JJPVAMC in consultation with scientists at Micro-Photonics.. 7.3.5 The contractor shall provide the digital data and write findings from the study in partnership with VA for publication in peer-reviewed journals. 7.4 Task 4: Educational and Informational Materials NA 8. Deliverable Table Note that the Deliverable Table is directly related to the tasks and deliverables in Section 7 above. Tasks Deliverable Planned Completion Date Task 1 7.1.1 Provide digital data of micro computerized X-ray tomography for 3D image reconstructions and quantitative morphological analyses of the cerebral vasculature in rodent models of blast TBI 15 business days after award of task order (TO) 9. Scope of Inspection This section will be a part of the Quality Assurance Surveillance Plan (QASP). Note that the table below is directly related to the tasks and deliverables in Sections 7 (Tasks) & 8 (Deliverable Table) above. The Contractor shall notify the CO/COR as soon as it becomes apparent to the contractor that a scheduled delivery shall be late. The contractor shall include in the notification the rationale for late delivery, the expected date for the delivery and the project impact of the late delivery. The CO/COR shall review the proposed schedule and provide guidance to the contractor via a TO modification. Such notification in no way limits the Government's right to any and all rights and remedies up to and including termination. All deliverables shall be inspected for content, completeness, accuracy and conformance to task order requirements by the CO/COR. Inspection may include validation of information as specified in the task order. All deliverables shall be checked for comprehensive to ensure the completeness, quality, and adequacy of all deliverables. The Government requires a period not to exceed thirty (30) days after receipt of deliverable items for inspection and acceptance or rejection. Inspection and acceptance of all work performance, reports and other deliverables under this task order shall be performed by the COR. Any further revisions required for government acceptance will be discussed between the COR and contractor. The COR s written approval of the draft and final documents shall constitute acceptance by the VA. The contractor shall notify the Government in writing, if problems arise that could adversely impact the performance of the Task Order. TASKS Task Ref Indicator/Deliverable Standard AQL Method(s) of Surveillance Program and Project Management Services 7.1.1 Provide and maintain a detailed Project Management Plan that includes a Quality Control Plan 15 business days after award of TO 95% 100% Inspection 7.1.2 Provide and maintain a detailed Project Plan 15 business days after award of TO 95% 100% Inspection 7.1.3 Provide a Confidentiality Plan and Data Security Procedures 15 business days after award of TO 95% 100% Inspection 7.1.4 Provide toll free number and email technical support 15 business days after award of TO 95% 100% Inspection 7.1.5 Prepare Agendas and minutes for weekly meetings Weekly after the start of the TO 95% 100% Inspection 7.1.6 Provide weekly reports during data collection Weekly after the start of data collection 95% 100% Inspection 7.1.7 Provide monthly reports during the award period Monthly 95% 100% Inspection Data Collection Surveys/Studies and Reporting 7.2.1 Assist with obtaining necessary IRB and OMB Approvals As agreed upon in the TO 85% Contractor-reported data 7.2.2 Develop Contact Information/ Locate Addresses: i.e. location algorithm (n=30,000) As agreed upon in the TO 90% Contractor-reported data 7.3.1 Provide focused methods and technique information papers As agreed upon in the TO PMP 85% Periodic Surveillance 7.3.2 Develop programming language for coding procedures As agreed upon in the TO PMP 90% Contractor-reported data 7.3.3 Develop an analysis plan for calculation of sampling weights and correction factors As agreed upon in the TO PMP 90% Contractor-reported data 7.3.4 Perform non-response analysis As agreed upon in the TO PMP 90% Periodic Surveillance 7.3.5 Write publications for peer-reviewed journals As agreed upon in the TO PMP 90% Contractor-reported data Educational and Informational Materials 7.4.1 Create an 1-page information sheet As agreed upon in the TO PMP 90% 100% Inspection; User Survey 7.4.2 Create and format brochures for marketing purposes As agreed upon in the TO PMP 90% User survey; Contractor-reported data 7.4.3 Create and format Fact Sheets As agreed upon in the TO PMP 90% User survey; Contractor-reported data 7.4.4 Create promotional materials As agreed upon in the TO PMP 90% Contractor-reported data; Progress Report
