This Subcontract opportunity from Department Of Defense was posted on December 11, 2025. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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AI-Powered Medical Image Analysis Development

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Federal

Submission Closed01/16/2026, 12:00:00 PM EST

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541715

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DHS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM FY27 PRE-SOLICITATION

Solicitation # DHSSBIRFY27PRE

The Department of Homeland Security (DHS) has issued a pre-solicitation for the FY27 Small Business Innovation Research (SBIR) Program, intended for planning purposes to prepare small business concerns for the upcoming 27.1 Solicitation. This program is structured into three phases: Phase I focuses on determining scientific and technical feasibility; Phase II aims to develop a well-defined deliverable prototype; and Phase III focuses on the commercialization of the research into viable products or services. The total contract duration, including options, cannot exceed 36 months, and all research and development must be performed within the United States. To be eligible, offerors must register with SAM.gov, the SBA Company Registration Database, and the DHS SBIR Portal. Entities majority-owned by venture capital firms, hedge funds, or private equity firms are ineligible, and Phase I applicants must meet or exceed the Phase II Transition Rate Benchmark. Proposals will be evaluated based on technical merit, staff qualifications, potential for commercialization, and cost reasonableness. Submissions must be made via the DHS SBIR Portal, adhering to strict formatting requirements, including a single PDF for the technical proposal and a JPEG or PNG for the briefing chart.

Sci Technology Acq Division

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Prototype development for Battlefield Wound Infection Prevention and Treatment (BWI P&T) Barrier Combination

Solicitation # HT9427-26-R-E020

The Defense Health Agency Contracting Activity is seeking a single award to develop a Battlefield Wound Infection Prevention and Treatment Barrier Combination prototype. This medical countermeasure must integrate a physical wound barrier with antimicrobial and antifungal properties to prevent systemic infections in combat scenarios. The project aims to advance the technology from a preferred starting point of Technology Readiness Level 5 to TRL 8, requiring the successful execution of preclinical testing, human clinical trials, and the achievement of FDA approval or clearance within the period of performance. The effort will be awarded under prototype Other Transaction Authority 10 U.S.C. 4022, with a preferred Firm Fixed Price structure, although Cost Plus Fixed Fee is acceptable. The estimated period of performance is 48 months, with specific objectives focused on prototype demonstration and regulatory submission. Proposals must be submitted in three distinct volumes covering technical, management, and administrative and cost details by November 20, 2026. Evaluation will be based on technical and management capability, cost, and demonstrated ability to perform, with a specific requirement for statutory eligibility under 10 USC 4022(d)(1) or a one-third cost share.

Defense Health Agency

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Cloud-Based Command and Control Plus (CBC2+) Voice Communications Request for Information (RFI)

Solicitation # FA861227RB003

The Department of the Air Force Portfolio Acquisition Executive for Command, Control, Communications and Battle Management is seeking information through a sources-sought solicitation for the Cloud-Based Command and Control Plus program. The objective is to identify mature commercial, non-developmental, government-developed, or emerging capabilities capable of integrating and managing voice and radio communications within cloud and edge command-and-control environments. This request for information, identified by solicitation number FA861227RB003 and NAICS code 541715, was posted on November 10, 2026. Interested parties must submit their responses by the deadline of December 11, 2026. The effort is managed by the Advanced Battle Management System Division out of Dayton, Ohio.

FA8612 Aflcmc C3BM C3

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Research Analysis and Final Report ProductionThis subcontract for Research Analysis and Final Report Production involves analyzing data collected from youth engagement activities for prime contractors working on Maidstone Borough Council projects. The selected provider will be responsible for synthesizing both qualitative and quantitative data using specialized tools such as NVivo or other survey analysis software to produce a comprehensive final report for the council. All work must be conducted in strict adherence to established social research methodology standards. Interested parties should note that the response deadline is November 23, 2026, and the project falls under NAICS code 541715.

Maidstone Borough Council

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Psychometric Validation and Learning Progression ConsultantThis subcontract opportunity is for a Psychometric Validation and Learning Progression Consultant to support prime contractors on projects for the Massachusetts Department of Elementary and Secondary Education. The selected consultant will be responsible for the research-based validation of assessment tools, the development of standards-aligned alternate achievement standards, and the creation of learning progressions featuring multiple entry points. Key deliverables include providing technical quality evidence for assessment models and submitting formal psychometric validation reports and published learning progression frameworks. The work is associated with NAICS code 541715 and is centered in Everett, Massachusetts, with a response deadline of December 15, 2026.

Department of Elementary and Secondary Education

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Material Property Predictive Modeling SoftwareThis subcontract, titled Material Property Predictive Modeling Software, involves the development of computational tools designed to predict material properties for prime contractors supporting DARPA Biological Technologies Office projects. The scope of work focuses on creating specialized algorithms and software that map these material properties to Department of War use cases. To achieve this, the contractor will utilize high-performance computing, molecular modeling software, and AI/ML frameworks to deliver predictive models and software tools across various defense applications. Managed under the Department of Defense and the Defense Advanced Research Projects Agency, the opportunity is categorized under NAICS code 541715. The solicitation was posted on November 12, 2026, with a response deadline set for December 2, 2026.

Defense Advanced Research Projects Agcy

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Ground and Lunar Demonstration ServicesThe Ground and Lunar Demonstration Services subcontract supports NASA Marshall Space Flight Center by maturing concepts through the use of ground-based analogs and simulations of lunar orbit and surface environments. The primary objective is to characterize the performance and reliability of systems for prime contractors while executing experimental research aimed at risk reduction. To successfully execute this work, the provider must possess specialized expertise in lunar environment simulation and have access to appropriate ground-based analog facilities. Administrative requirements for this engagement include the ability to handle Controlled Unclassified Information. The selected provider will be responsible for delivering detailed reliability data and performance characterization reports. This opportunity is categorized under NAICS code 541715, with a response deadline set for January 4, 2027.

NASA Marshall Space Flight Center

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Scientific Research and Concept Exploration ServicesThe Scientific Research and Concept Exploration Services subcontract supports prime contractors on projects for the NASA Marshall Space Flight Center. The scope of work involves conducting initial investigations, preliminary research, and theoretical analyses of concept fundamentals to evaluate strategic relevance and explore design parameter relationships. Key deliverables include comprehensive research reports and feasibility analyses. Qualified providers must possess deep expertise in systems engineering processes and NASA technical standards. Additionally, personnel must be capable of handling Controlled Unclassified Information. This opportunity is categorized under NAICS code 541715, with a response deadline set for January 4, 2027.

NASA Marshall Space Flight Center

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Request for Information (RFI) - EmbraceHEALTH Clinical Research Network (EmbraceHEALTH CRN) - Coordinating Center

Solicitation # 75N94027R00003

The National Institute on Minority Health and Health Disparities (NIMHD) within the National Institutes of Health (NIH) has issued Request for Information (RFI) 75N94027R00003 to gather industry input for the establishment and operation of a Coordinating Center (CC) for the EmbraceHealth Clinical Research Network (CRN). This is a market research effort and not a formal solicitation for proposals. The anticipated NAICS code is 541715, covering Research and Development in the Physical, Engineering, and Life Sciences. The government is seeking feedback on a draft Statement of Work and is evaluating the commercial availability of services to inform future acquisition planning, including the potential for a small business set-aside. The Coordinating Center will provide centralized scientific, statistical, methodological, data management, and administrative support to the NIMHD and the EmbraceHealth CRN Research Consortia. Key responsibilities include guiding research protocol development, managing electronic data capture, providing biostatistical consultation, and ensuring regulatory and quality assurance compliance for multi-site clinical and health services research aimed at reducing health disparities. The selected contractor will be required to develop a Network Operations Plan and establish governance structures, such as a Data and Safety Monitoring Board, to ensure participant safety and scientific rigor. Responses to the RFI are due by November 17, 2026.

National Institutes Of Health Nichd

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NextSTEP-3 Appendix B: Moon Base Demonstrations

Solicitation # M2M-MSFC-0001

The Next Space Technologies for Exploration Partnerships-3 (NextSTEP-3), Appendix B: Moon Base Demonstrations, is a solicitation issued by the NASA Marshall Space Flight Center to advance lunar mission capabilities. The program focuses on bridging the gap between technology development and mission operations by targeting concepts at Technology Readiness Level (TRL) 6 and beyond. Key technical areas include infrastructure, transportation, mobility, habitation, autonomy, robotics, and mission science. The contract is structured as an Indefinite-Delivery, Indefinite-Quantity (IDIQ) vehicle utilizing Firm-Fixed-Price (FFP) task orders, with a performance period spanning from October 27, 2026, to October 26, 2028. NASA utilizes a dual-path call structure consisting of Directed-Topic Calls for specific mission needs—such as Moon Base Data Gaps and Surface Mating Systems—and Open-Topic Calls for broader industry innovation. The selection process is a two-step sequence starting with a white paper submission, followed by a full proposal for invited parties. Awards are determined via a best-value tradeoff process, where intrinsic merit and management approach are weighted more heavily than price. All contractors must adhere to strict NASA technical standards, cybersecurity requirements, and a prohibition on funding activities with Chinese-owned companies.

NASA Marshall Space Flight Center

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16th Air Force Commercial Solutions Opening

Solicitation # FA7037-23-S-C0001

The 16th Air Force is utilizing a Commercial Solutions Opening (CSO) under 10 USC 3458 and DFARS 212.70 to acquire innovative commercial items, technologies, and services. This overarching umbrella solicitation, numbered FA7037-23-S-C0001, allows the Air Force to issue various Calls to address capability gaps and technological advancements. Key areas of interest include Electromagnetic Warfare, Information Operations, Electromagnetic Digital Communications, and Multi-Domain Innovation. All acquisitions under this framework are treated as commercial items, and awards may be issued as traditional contracts or Other Transaction Agreements. The procurement process generally follows a two-step evaluation based on peer or scientific review. In Step I, offerors submit a Quad Chart and a White Paper to demonstrate technical qualification and merit. If selected, the government invites the offeror to submit a Step II Technical Proposal. While many previous calls for projects such as CFD Modeling, WAPS Scheduling, and AI-Enabled Security Operations have closed, Call 0013 for Innovative Electromagnetic Spectrum Operations Signature Management Support remains open for submissions through November 23, 2026. Offerors must be registered in SAM.gov with a Unique Entity Identifier and CAGE code, and must adhere to specific cybersecurity and classification standards depending on the call requirements.

FA7037 Amic Det 2 Jbsa

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Request for Information (RFI) - EmbraceHEALTH Clinical Research Network (EmbraceHEALTH CRN)

Solicitation # 75N94027R00002

The National Institute on Minority Health and Health Disparities (NIMHD) within the National Institutes of Health (NIH) has issued Request for Information (RFI) 75N94027R00002 to conduct market research for the establishment of the EmbraceHEALTH Clinical Research Network (CRN). The government intends to create a multiple-award Indefinite Delivery, Indefinite Quantity (IDIQ) contract to support approximately five Research Consortia (RCs) and a Coordinating Center (CC). This network will focus on clinical, behavioral, and health services research, utilizing designs such as randomized controlled trials and implementation research to reduce health disparities and improve outcomes for underserved populations. The anticipated ordering period for resultant contracts is approximately five years, with specific research activities managed on a task order basis. The scope of work requires contractors to demonstrate organizational capacity and established partnerships with academic institutions, safety net health care settings, or Federally Qualified Health Centers. Key operational requirements include the ability to manage core research operations, maintain strict regulatory compliance, and establish infrastructure for the collection, processing, storage, and secure transfer of biospecimens. The government is seeking input from all interested organizations, regardless of size, under NAICS code 541715. While this RFI is for planning purposes and is not a formal solicitation, the government may use the responses to determine if the final acquisition will be a small business set-aside.

National Institutes Of Health Nichd

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1 day ago

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AI Contract Overview

The AI-Powered Medical Image Analysis Development subcontract, issued by the Defense Health Agency under the Department of Defense, focuses on the creation and integration of advanced AI algorithms. These tools are intended to enhance medical imaging capabilities specifically for endoscopic images, providing critical support for diagnostic accuracy, quality assurance, and the analysis of clinical trends. Interested parties must submit their responses by January 16, 2026. The project falls under NAICS code 541715 and will be performed in the 21702 zip code area. This initiative represents a strategic effort to leverage artificial intelligence to improve healthcare outcomes through automated image analysis.