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This Pre-Solicitation opportunity from Department Of Veterans Affairs was posted on July 15, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

AJ13--Liposome Preparation for Experimental Rheumatoid Arthritis treatment

Closed
36C24526Q0665Federal

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The Department of Veterans Affairs, through Network Contracting Office 05, is preparing to issue a solicitation for the development and characterization of custom liposomal formulations designed for targeted delivery of an anti-arthritis drug to joints, leveraging proprietary VA-owned lipid compositions and a patented targeting peptide known as ART2. This effort supports experimental rheumatoid arthritis therapy research and requires a contractor with demonstrated expertise in nanoparticle formulation, surface functionalization with peptides, encapsulation of therapeutic agents, and comprehensive analytical characterization including particle size, zeta potential, polydispersity index, and drug quantification via LC MS/MS or HPLC. Full technical specifications including lipid ratios and ART2 conjugation protocols will only be disclosed after execution of a Confidential Disclosure Agreement with the VA Technology Transfer Program, ensuring protection of patented intellectual property. Contractors must be capable of producing research-grade liposomal systems with certified analysis documentation and delivering materials suitable for non-GLP exploratory studies. The solicitation, expected to be posted on SAM.gov under solicitation number 36C24526Q0665, will outline detailed performance requirements, evaluation criteria, and procedural guidance for accessing proprietary information. Interested parties must monitor SAM.gov for the official release and understand that no responses are solicited at this pre-solicitation stage, nor will the government reimburse any preparatory costs. All inquiries must be directed to the designated contracting officer via email only, and no phone contact is permitted. Selection of vendors will require completion of a CDA prior to receipt of sensitive technical details.

General Info

VA seeks contractor to develop custom liposomal arthritis drug delivery using patented lipids and ART2 peptide.

NAICS

325412 - Pharmaceutical Preparation Manufacturing

Place of Performance

Contractor's facility / laboratory, MD, 20422, USA

Set-Aside

NONE

Documents

2

Pre-Solicitation Notice for Liposome Preparation for Arthritis Therapy - 36C24526Q0665

DOCX, Low prioritypresolicitation
Low

Sources Sought Notice 36C24526Q0665 - Liposome Preparation for Arthritis Therapy

DOCX, Low prioritysources-sought
Low

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Timeline

PhaseClosed
Posted

Sources Sought

Type Changed

Sources Sought → Presolicitation

Response Deadline

Deadline has passed

Submission Closed

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Organization & Contact Information

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AgencyDepartment Of Veterans Affairs → 245-NETWORK Contract Office 5 (36C245)
Contacts1 person available
OfficeLINTHICUM, MD, 21090, USA
Office AddressLINTHICUM, MD, 21090, USA
Contacts
Robert O'Keefe JrContracting Officer

Full Description

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PRE SOLICITATION NOTICE
Department of Veterans Affairs Network Contracting Office 05 (NCO 05) Joint Targeted Drug Delivery Approach for Arthritis Therapy Liposome Preparation NAICS: 325412 Pharmaceutical Preparation Manufacturing PSC: AJ13 R&D Biomedical, Advanced Development
1. Announcement
The Department of Veterans Affairs, Network Contracting Office (NCO) 05, intends to issue a solicitation for the preparation and characterization of specialized liposomal formulations incorporating patented joint targeting technologies. This notice serves as a Pre Solicitation Notice only and is issued in accordance with FAR 5.204.
This notice is not a request for quotes or proposals, and no responses are required at this time.
2. Summary of Requirement
The forthcoming solicitation will seek a qualified contractor capable of producing research grade liposomes utilizing: A patented lipid composition A patented joint targeting peptide (ART2) Encapsulation of an anti arthritis drug Standard physicochemical characterization of nanoparticle/liposome systems This work supports VA owned intellectual property associated with an experimental drug delivery system intended for arthritis therapy. Full technical details, including lipid composition, ratios, and ART2 functionalization methods will be released only after completion of a Confidential Disclosure Agreement (CDA) with the VA Technology Transfer Program.
3. Anticipated Contractor Capabilities
The forthcoming solicitation will require vendors with demonstrated capability in: Custom nanoparticle or liposome formulation using sponsor specified lipid systems Peptide or ligand functionalization of nanoparticle surfaces Drug encapsulation and documentation of encapsulation efficiency Analytical nanoparticle characterization (particle size, zeta potential, PDI, drug loading) LC MS/MS or HPLC drug quantification Delivery of research grade formulations for non GLP exploratory studies Production of Certificates of Analysis (COA) for liposomal drug systems
4. Security and Intellectual Property Restrictions
The lipid composition and ART2 peptide functionalization process are proprietary and patented by the VA. Distribution of proprietary information will require: Execution of a Confidential Disclosure Agreement (CDA) with the VA Technology Transfer Program prior to release of any technical specifications.
5. Solicitation Release Information
The formal solicitation (Request for Quote or Request for Proposal) is expected to be posted on SAM.gov. The solicitation will include: Detailed performance requirements Instructions to offerors Evaluation criteria CDA instructions for accessing proprietary specifications Vendors are responsible for monitoring SAM.gov for updates.
6. Point of Contact
Contracting Officer: Robert O Keefe Jr. Email: contact@example.gov
No phone inquiries will be accepted. All questions will be addressed after formal solicitation issuance.
7. Disclaimer
This Pre Solicitation Notice does not constitute a solicitation. It does not request proposals or quotes and does not obligate the Government to award a contract. The VA will not reimburse any costs associated with preparation or submission of information in response to this notice. Upon completion of market research and release of the solicitation, selected vendors will be required to sign a Confidential Disclosure Agreement (CDA) prior to receiving proprietary materials and full technical specifications.

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