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NAICS Code· 325412

NAICS 325412: Pharmaceutical Preparation Manufacturing

This U.S. industry comprises establishments primarily engaged in manufacturing in-vivo diagnostic substances and pharmaceutical preparations (except biological) intended for internal and external consumption in dose forms, such as ampoules, tablets, capsules, vials, ointments, powders, solutions, and suspensions. Cross-References. Establishments primarily engaged in--Show more

NAICS 325412 – Pharmaceutical Preparation Manufacturing encompasses the formulation, production, and packaging of finished pharmaceutical products, including sterile injectables, oral solids, topical creams, and other dosage forms intended for human or veterinary use. This sector involves complex manufacturing processes governed by cGMP standards, requiring validated equipment, rigorous quality control, and strict environmental controls to ensure product safety and efficacy.

97
Active Contracts
$17.8B
Total Obligations (12mo)
13.1K
Awarded Contracts (12mo)
336
Contractors Awarded (12mo)
1
Median Bidders per Award
-11.4%
YoY Growth

Industry Spending Overview

Federal obligations, top contractors and agencies, and related industry codes for NAICS 325412.

AI Industry Description

NAICS 325412 – Pharmaceutical Preparation Manufacturing encompasses the formulation, production, and packaging of finished pharmaceutical products, including sterile injectables, oral solids, topical creams, and other dosage forms intended for human or veterinary use. This sector involves complex ma...

NAICS 325412 – Pharmaceutical Preparation Manufacturing encompasses the formulation, production, and packaging of finished pharmaceutical products, including sterile injectables, oral solids, topical creams, and other dosage forms intended for human or veterinary use. This sector involves complex manufacturing processes governed by cGMP standards, requiring validated equipment, rigorous quality control, and strict environmental controls to ensure product safety and efficacy. In government contracting, this NAICS supports critical public health and military readiness initiatives, with agencies procuring medications for clinical use, emergency stockpiles, and deployed medical units. The industry bridges advanced chemistry, regulatory compliance, and supply chain resilience, making it a high-stakes segment within federal healthcare and defense procurement. Top contractors in this sector include ALTITUDE TECHNOLOGIES INC., MARATHON MEDICAL CORPORATION, NANOSONICS INC, LINDE GAS & EQUIPMENT INC., and BHPE LLC, representing a mix of specialized pharmaceutical manufacturers, medical device integrators, and gas supply providers supporting sterile production environments. These firms range from mid-sized primes to niche technical service providers, indicating a competitive landscape where regulatory expertise and cold-chain logistics capabilities are as critical as manufacturing scale. The Department of Health and Human Services, Department of Veterans Affairs, and Department of Defense are the primary buyers, driving demand through hospital formularies, VA pharmacy networks, and military medical readiness programs. Procurement focuses on FDA-approved therapeutics, pandemic preparedness stockpiles, and battlefield medical supplies requiring extended shelf life and transport stability. The market is characterized by high barriers to entry due to FDA oversight and cGMP compliance, but offers consistent demand from mission-critical agencies. Opportunities exist for contractors with validated manufacturing facilities, sterile compounding capabilities, and experience in federal supply chain protocols. Recent trends show increased emphasis on domestic sourcing and resilient production networks to reduce reliance on foreign active pharmaceutical ingredients.

Small Business Size Standard

The SBA threshold that decides who can bid NAICS 325412 work as a small business.

1,300 employees
Applies to the whole industry code

The SBA cap for this NAICS (13 CFR 121.201). A business at or under it can self-certify as small for work in this code, which is what makes it eligible for a small-business set-aside. The cap is set per NAICS, so the same company can be small in one code and not in another.

13 CFR 121.201, effective January 1, 2026. The SBA revises the table roughly once a year.

Top Contractors

Companies with the highest total award value under NAICS 325412, ranked by dollars won.

Ranked by total awards
CompanyTotal AwardsContracts
MCKESSON CORPORATION$11.1B1,445
MERCK SHARP & DOHME LLC$1.8B23
GLAXOSMITHKLINE, LLC$775.4M9
IPSEN BIOPHARMACEUTICALS INC$760.7M2
PFIZER INC$713.9M990
SANOFI VACCINES US INC.$656.6M115
VIVUS LLC$285.7M2
DECIPHERA PHARMACEUTICALS, LLC$183.8M2
GOLDEN STATE MEDICAL SUPPLY, INC.$177.9M254
EXELAN PHARMACEUTICALS INC$144.7M92

Top Agencies

Federal agencies directing the most contract spending toward NAICS 325412.

Department Of Veterans Affairs1,225 awards$12.8B
Department Of Health And Human Services114 awards$4.4B
Department Of Defense10,036 awards$339.9M
Department Of Justice1,656 awards$151.5M
Department Of Homeland Security8 awards$22.2M
Department Of Agriculture5 awards$4.1M
Department Of State6 awards$774K
Peace Corps20 awards$496K
Department Of The Interior (doi)2 awards$441K
Department Of Commerce4 awards$134K

Competition

How many companies historically bid on federal awards in NAICS 325412, from bidder counts reported on USAspending.

Usually Single-Bid

Half or more of reported awards drew exactly one bidder, usually a sign of incumbent-held work rather than an open field. · 213,942 reported awards

Median Bidders

1

Per reported award, all-time

Single-Bid Awards

62%

Share of reported awards with one bidder

10+ Bidder Awards

3%

Share of reported awards with 10+ bidders

Reported Awards

213,942

61% of 351,274 total awards

Bidder Count Distribution by Fiscal Year

Share of reported awards in each bidder-count bracket per federal fiscal year.

How this code compares up the NAICS hierarchy. Parent cohorts pool every code under their prefix, so they are the steadier baseline when a 6-digit sample is thin.

Industry FamilyCompetitionMedian BiddersSingle-BidBidder MixReported Awards
325412This Code
Pharmaceutical Preparation Manufacturing
Usually Single-Bid162%
213,94261% of 351,274
32541NAICS Industry
Moderate Competition434%
768,09830% of 2,598,155
3254Industry Group
Pharmaceutical and Medicine Manufacturing
Moderate Competition434%
768,09830% of 2,598,155
325Subsector
Moderate Competition336%
1,586,81435% of 4,520,357
32Sector
Manufacturing
Moderate Competition331%
3,156,13129% of 10,975,761

Bidder counts reported on past federal awards in this NAICS (USAspending). An open opportunity has no bidders yet, so this is the historical norm for similar work, not a fact about this solicitation. Not all awards report bidder counts, and fewer bidders often means incumbent-held work rather than an easier win. Federal reporting of bidder counts fell from ~96% of awards (FY2016) to ~30% (FY2018 onward); the chart shows shares of reported awards, and washed-out stretches mark years with fewer than 30 of them.

Related NAICS Codes

Industries similar to Pharmaceutical Preparation Manufacturing, by shared sector, subsector, and industry group.

Medicinal and Botanical Manufacturing

This U.S. industry comprises establishments primarily engaged in (1) manufacturing uncompounded medi...
325411Same Industry GroupHigh Similarity

In-Vitro Diagnostic Substance Manufacturing

This U.S. industry comprises establishments primarily engaged in manufacturing in-vitro (i.e., not t...
325413Same Industry GroupHigh Similarity

Biological Product (except Diagnostic) Manufacturing

This U.S. industry comprises establishments primarily engaged in manufacturing vaccines, toxoids, bl...
325414Same Industry GroupHigh Similarity

Petrochemical Manufacturing

This industry comprises establishments primarily engaged in (1) manufacturing acyclic (i.e., aliphat...
325110Same SubsectorMedium Similarity

Industrial Gas Manufacturing

This industry comprises establishments primarily engaged in manufacturing industrial organic and ino...
325120Same SubsectorMedium Similarity

Synthetic Dye and Pigment Manufacturing

This industry comprises establishments primarily engaged in manufacturing synthetic organic and inor...
325130Same SubsectorMedium Similarity

Other Basic Inorganic Chemical Manufacturing

This industry comprises establishments primarily engaged in manufacturing basic inorganic chemicals ...
325180Same SubsectorMedium Similarity

Ethyl Alcohol Manufacturing

This U.S. industry comprises establishments primarily engaged in manufacturing nonpotable ethyl alco...
325193Same SubsectorMedium Similarity

Explore contracts across multiple NAICS codes Browse all NAICS Codes

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NAICS 325412 FAQ

Frequently Asked Questions

NAICS code 325412 covers Pharmaceutical Preparation Manufacturing. This U.S. industry comprises establishments primarily engaged in manufacturing in-vivo diagnostic substances and pharmaceutical preparations (except biological) intended for internal and external consumption in dose forms, such as ampoules, tablets, capsules, vials, ointments, powders, solutions, and suspensions. Cross-References. Establishments primarily engaged in--

Recently Posted in Pharmaceutical Preparation Manufacturing

NAICS: 325412
New
DIBBS
Manufacturer of Ultrasonic Dental Cleaning CompoundsThis subcontract involves the chemical formulation and production of Maxizyme enzyme cleaning tablets intended for prime contractors supporting Defense Logistics Agency medical supply contracts. The scope of work encompasses the full manufacturing process, including chemical synthesis, the formulation of enzyme cleaners specifically for ultrasonic dental cleansing, and the compression of these compounds into final tablet form using specialized chemical processing equipment and tablet presses. The manufacturer is required to adhere strictly to the DLA Master List of Technical and Quality Requirements as well as Medical Marking Standard No. 1 to ensure regulatory compliance. The final deliverable consists of packaged Maxizyme Tablets provided to the Department of Defense via the Medical Supply Chain. This opportunity falls under NAICS code 325412 and is managed through the DLA system.
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NAICS: 325412
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Supply of Electrical Insulation Tape (NSN 5970-01-258-1216)This subcontract involves the supply of electrical insulation tape for prime contractors working under the Defense Logistics Agency Weapons Support ASC Supplier Oper AE and AF Division. The selected provider is responsible for manufacturing or sourcing tape that strictly adheres to technical specifications for NSN 5970-01-258-1216. All deliverables must be packaged according to RP001 standards and marked and labeled in compliance with RQ017 requirements, necessitating the use of packaging facilities capable of meeting these specific DLA standards. The opportunity is categorized under NAICS code 325412 and is managed by the Department of Defense. Performance of the contract will take place in APO 96328-5120. Interested parties must note the response deadline of October 26, 2026, to submit their proposals for the delivery of these physical materials.
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NAICS: 325412
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Supply of Orange Flavored Electrolyte Oral Hydration PowderThis subcontract involves the manufacture or distribution of medical-grade orange-flavored electrolyte oral hydration powder to support prime contractors for the Department of Defense Medical Supply Chain Pharm FSA. The required product must meet NSN 6505016871441, provided in 21 GM units packaged in quantities of 100, while adhering to Medical Marking Standard No. 1 and commercial packing standards. The contract mandates strict compliance with the Buy American Act, the Berry Amendment, and NIST SP 800-171 cybersecurity standards. Performance takes place at FPO 09591-2600, with a response deadline of October 26, 2026.
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Supply of Lactated Ringer's InjectionThis subcontract involves the supply of Lactated Ringer's Injection, USP, 1000ML, 12S for prime contractors supporting the Department of Defense Medical Supply Chain Pharm FSA. The selected provider must manufacture or wholesale these medical fluids in accordance with USP standards and FDA regulations, ensuring a minimum shelf life of 30 months. All products must be packaged in commercial sealed units following MIL-STD-2073-1E and RP001 guidelines and marked according to Medical Marking Standard No. 1. The contract requires delivery of completed orders FOB Destination to a performance location in FPO 96660. Interested parties must respond by October 26, 2026, for this requirement categorized under NAICS code 325412.
MEDICAL SUPPLY CHAIN PHARM FSA

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1 day ago

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NAICS: 325412
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RINGER'S INJECTION, LAC
Solicitation # SPE2DP-27-T-0121
Solicitation SPE2DP-27-T-0121 is a request for quotations issued by the DLA Troop Support Medical Supply Chain Pharm FSA for the procurement of Ringer's Injection, Lactated, USP, 1000ML, 12S, identified by NSN 6505013306267. The requirement consists of one package (PG) with a delivery timeline of 20 days after order, and an original required delivery date of October 20, 2026. Delivery is FOB Destination, with shipping addresses including USNS Able T-AGOS 20 and locations in Colchester, Vermont. The item is regulated by the FDA and has a non-extendable shelf life of 30 months. Packaging must be commercial and compliant with MIL-STD-2073-1E and RP001, with specific requirements to use sealed unit containers to prevent damage. Marking must adhere to Medical Marking Standard No. 1, which supersedes MIL-STD-129. Storage requires protection from freezing and excessive heat, with a recommended room temperature of 25 degrees Celsius. The contract incorporates several federal regulations, including the Buy American and Balance of Payments Program, basic safeguarding of covered contractor information systems, and the Hazard Communication Standard for any hazardous materials. Invoicing must be processed electronically through the Wide Area WorkFlow system.
MEDICAL SUPPLY CHAIN PHARM FSA

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NAICS: 325412
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MEDICINE BALL
Solicitation # SPE2DS-27-T-0734
Solicitation SPE2DS-27-T-0734 is a request for quotations issued by the DLA Troop Support Medical Supply Chain for the procurement of five blue medicine balls used for physical therapy. The required items must have a nominal diameter of 7 inches and a weight of 6.6 lbs (3 kg), corresponding to NSN 7830016007777 and part number A926115. Delivery is required within five days after receipt of the order, with the shipping destination specified as Rose Barracks South Camp in Germany. The contract is established as FOB Destination, and inspection and acceptance will also occur at the destination. The contractor must adhere to strict packaging and marking standards, specifically utilizing Medical Marking Standard No. 1, which supersedes MIL-STD-129. Packaging must be commercial grade, with each unit in a sealed container to prevent damage. The procurement is governed by various FAR and DFARS clauses, including those regarding the Buy American Act, the Berry Amendment, and cybersecurity requirements under DFARS 252.204-7012. Invoicing and payment must be processed electronically through the Wide Area WorkFlow system. Offerors are required to submit quotes via the DIBBS portal and must maintain active registration in the System for Award Management.
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NAICS: 325412
New
DIBBS
CHLORINE TEST REAGENT
Solicitation # SPE2DS-27-T-0723
Solicitation SPE2DS-27-T-0723 is a fixed-price procurement issued by the Department of Defense Medical Supply Chain for the supply of Chlorine Test Reagent (NSN 6550-01-460-7597). The requirement is for two packages, with each package containing 100 powder pillows for a 10 ML sample size using DPD Total Chlorine Reagent. Delivery is required within 5 days after receipt of order, with a specified delivery date of October 20, 2026, and the place of performance located in Pascagoula, Mississippi. The contract mandates strict quality and shelf-life requirements, specifying a non-extendable shelf life of 60 months, with no more than 8 months elapsed from the date of manufacture to the date of delivery. Packaging must be commercial and adhere to DLA Packaging Requirements for Procurement (RP001), with medical acquisitions specifically requiring marking according to Medical Marking Standard No. 1. All labels must include the contract or lot number and the manufacture, expiration, or retest date. Administrative requirements include the use of the Wide Area WorkFlow (WAWF) system for invoicing and payment. Offerors must be registered in the System for Award Management (SAM) and comply with the Buy American Act and DFARS safeguarding of covered defense information. Inspection and acceptance will occur at the destination.
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NAICS: 325412
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DIBBS
POVIDONE-IODINE CLEANS
Solicitation # SPE2DP-27-T-0119
Solicitation SPE2DP-27-T-0119 is a fixed-price procurement by the Defense Logistics Agency for four one-gallon bottles of Povidone-Iodine Cleansing Solution, USP 7.5% active ingredient. This FDA-regulated drug must be delivered FOB Destination within five days of the award. The product has a total shelf life of 36 months, with a requirement that at least 31 months of shelf life remain upon delivery to the first government activity. Storage must be maintained at 25 degrees Celsius, with permitted excursions between 15 and 30 degrees Celsius. The contract mandates strict adherence to the DLA Master List of Technical and Quality Requirements and Medical Marking Standard No. 1, which supersedes MIL-STD-129 for medical marking. Packaging must be commercial and sealed to prevent damage, with specific requirements for hazardous materials under FED-STD-313 and TQ requirement IP025, or ASTM D3951 for non-hazardous materials. Suppliers must provide Safety Data Sheets and HCS labels in accordance with 29 CFR 1910.1200. Administrative requirements include the use of the Wide Area WorkFlow system for invoicing and compliance with the Buy American Act and Berry Amendment regarding domestic sourcing. Inspection and acceptance will occur at the destination.
MEDICAL SUPPLY CHAIN PHARM FSA

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1 day ago

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in 7 days
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NAICS: 325412
Awarded
DIBBS
SODIUM CHLORIDE INJECTION
Solicitation # SPE2D927F0140
Contract award SPE2D927F0140 was issued by the Defense Logistics Agency Troop Support Medical Supply Chain to Cardinal Health, Inc. for the procurement of Sodium Chloride Injection. This delivery order, operating under the broader contract SPE2DX25D8022 and solicitation SPE2DX-24-R-0001, was finalized on October 17, 2026. The acquisition is categorized under NAICS code 325412 and was designated as a Women-Owned Small Business set-aside. The total contract price is 33.41 dollars for a quantity of one package of the injection, identified by NSN 6505013306269. The order specifies a rapid delivery timeline, with the product scheduled for delivery to the USS WYOMING SSNB 742 by October 19, 2026.
Defense Logistics Agency

POSTED

2 days ago

DEADLINE

N/A
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NAICS: 325412
Awarded
DIBBS
SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLET
Solicitation # SPE2D927F0139
Defense Logistics Agency award SPE2D927F0139 is a delivery order issued to Cardinal Health, Inc. for the procurement of Sulfamethoxazole and Trimethoprim tablets. The contract, associated with NAICS code 325412 and delivery order SPE2DX25D8022, was awarded on October 17, 2026, for a total price of 143.14 dollars. The procurement was managed by DLA Troop Support Medical Supply Chain under solicitation SPE2DX-24-R-0001 and is designated as WOSB eligible. The specific line item consists of tablets under NSN 6505010161470, with a required delivery date of October 19, 2026, for shipment to the USS Kingsville LCS 36.
Defense Logistics Agency

POSTED

2 days ago

DEADLINE

N/A
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NAICS: 325412
Awarded
DIBBS
KETAMINE HYDROCHLORIDE INJECTION
Solicitation # SPE2D927F0141
Defense Logistics Agency award SPE2D927F0141 is a delivery order issued under basic contract SPE2DX25D8022 to Cardinal Health, Inc. for the procurement of Ketamine Hydrochloride Injection. The contract, categorized under NAICS code 325412, was awarded on October 17, 2026, for a total price of 201.65 dollars. The order specifies the delivery of five units of Ketamine Hydrochloride Injection, identified by NSN 6505013391909 and PR 7018773903, to the USS Milius (DDG 69). The required delivery date for these medical supplies was set for October 19, 2026. This procurement was managed by DLA Troop Support Medical Supply Chain.
Defense Logistics Agency

POSTED

2 days ago

DEADLINE

N/A
View Details
NAICS: 325412
Awarded
DIBBS
PERMETHRIN CREAM RINSE
Solicitation # SPE2DP-26-T-4477
Permectrin Cream Rinse is a 1% w/v topical medication packaged as a 2 fl oz plastic squeeze bottle, each unit including a comb for application, and supplied in individual units with a minimum of 21 months of remaining shelf life at time of receipt by the government, ensuring a 24-month total shelf life is maintained. The item is regulated by the FDA and must comply with all applicable medical, packaging, and hazardous materials standards including Medical Marking Standard No. 1, which supersedes MIL-STD-129, and packaging requirements that ensure protection from damage during shipping and compliance with commercial standards for both interior and exterior containers. All shipments must include a current Safety Data Sheet (SDS) formatted per 29 C.F.R. 1910.1200, with labels meeting OSHA’s Hazard Communication Standard and the Globally Harmonized System, and these documents must be submitted for approval before contract award. Each shipment must also carry a copy of the SDS and be marked in accordance with the approved medical marking guidelines. The product is subject to DLA’s technical and quality requirements as outlined in the DLA Master List, and must comply with all applicable transportation regulations including 49 CFR and ICAO standards for hazardous materials. The NSN is 6505-01-256-4972, with two units requested under solicitation SPE2DP-26-T-4477, with a 20-day delivery requirement and a contract awarded to a government activity under the Department of Defense.
Defense Logistics Agency

POSTED

3 days ago

DEADLINE

N/A
View Details

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