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NAICS Code· 325411

Medicinal and Botanical Manufacturing

This U.S. industry comprises establishments primarily engaged in (1) manufacturing uncompounded medicinal chemicals and their derivatives (i.e., generally for use by pharmaceutical preparation manufacturers) and/or (2) grading, grinding, and milling uncompounded botanicals. Cross-References. Establishments primarily engaged in--Show more

NAICS 325411 – Medicinal and Botanical Manufacturing encompasses the production of pharmaceuticals, botanical extracts, and active pharmaceutical ingredients derived from natural or synthetic sources, including standardized herbal formulations, alkaloids, and biologically active compounds used in therapeutic applications. This sector supports government health, defense, and humanitarian missions through the development of FDA-regulated drug products, antimicrobial agents, and specialized medicinal formulations for field use.

17
Active Contracts
$4.0B
Total Obligations (12mo)
93.4K
Awarded Contracts (12mo)
65
Contractors Awarded (12mo)
-22.0%
YoY Growth

Industry Spending Overview

Federal obligations, top contractors and agencies, and related industry codes for NAICS 325411.

AI Industry Description

NAICS 325411 – Medicinal and Botanical Manufacturing encompasses the production of pharmaceuticals, botanical extracts, and active pharmaceutical ingredients derived from natural or synthetic sources, including standardized herbal formulations, alkaloids, and biologically active compounds used in th...

NAICS 325411 – Medicinal and Botanical Manufacturing encompasses the production of pharmaceuticals, botanical extracts, and active pharmaceutical ingredients derived from natural or synthetic sources, including standardized herbal formulations, alkaloids, and biologically active compounds used in therapeutic applications. This sector supports government health, defense, and humanitarian missions through the development of FDA-regulated drug products, antimicrobial agents, and specialized medicinal formulations for field use. In federal contracting, this NAICS code bridges pharmaceutical innovation with mission-critical supply chains, particularly where rapid deployment, shelf stability, and bioavailability are paramount. Products manufactured under this code often interface with military medical logistics, foreign medical assistance programs, and public health preparedness initiatives. Top contractors in this sector include ALTITUDE TECHNOLOGIES INC., a specialized firm leveraging advanced formulation science for government-grade pharmaceuticals, and 3M COMPANY, a large prime with extensive capabilities in sterile manufacturing, drug delivery systems, and bioactive material integration. These entities represent a mix of niche pharmaceutical innovators and diversified industrial manufacturers with robust GMP compliance and defense supply chain credentials. The Department of Defense and the Department of State are the primary procuring agencies, driving demand through military medical readiness programs, overseas humanitarian aid, and chemical/biological threat countermeasures. Their procurement priorities center on secure, scalable production of stable, mission-specific therapeutics and prophylactics for austere environments. The competitive landscape is characterized by high regulatory barriers and stringent quality control requirements, favoring contractors with established cGMP facilities, FDA registrations, and experience in controlled substance handling. Opportunities are concentrated in contract manufacturing, bulk API synthesis, and rapid-response formulation development, with increasing demand for botanical-derived compounds in integrative medical protocols. Contractors with expertise in cold-chain logistics, controlled substance licensing, and DoD-specific documentation standards are best positioned to compete.

Top Contractors

Companies with the highest total award value under NAICS 325411, ranked by dollars won.

Ranked by total awards
CompanyTotal AwardsContracts
AMERISOURCEBERGEN DRUG CORP$3.8B79,304
GOLDEN STATE MEDICAL SUPPLY, INC.$135.5M2
EMERGENT BIODEFENSE OPERATIONS LANSING LLC$21.5M1
DMS PHARMACEUTICAL GROUP INC$11.2M5,844
CARDINAL HEALTH, INC.$3.9M1,896
ATLANTIC DIVING SUPPLY, INC.$2.6M841
ANIMAL HEALTH INTERNATIONAL, INC.$2.2M3
FRESENIUS KABI, LLC$1.8M563
ALTITUDE TECHNOLOGIES INC.$1.4M713
PHOENIX TEXTILE CORPORATION$1.2M705

Top Agencies

Federal agencies directing the most contract spending toward NAICS 325411.

Department Of Defense93,415 awards$3.9B
DLA Troop Support3 awards$135.6M
Department Of The Interior3 awards$2.2M
Department Of Veterans Affairs2 awards$413K
Department Of Health And Human Services4 awards$193K
Department Of State3 awards$75K
Department Of Justice1 award$15K
Department Of Agriculture1 award$13K

Related NAICS Codes

Industries similar to Medicinal and Botanical Manufacturing, by shared sector, subsector, and industry group.

Pharmaceutical Preparation Manufacturing

This U.S. industry comprises establishments primarily engaged in manufacturing in-vivo diagnostic su...
325412Same Industry GroupHigh Similarity

In-Vitro Diagnostic Substance Manufacturing

This U.S. industry comprises establishments primarily engaged in manufacturing in-vitro (i.e., not t...
325413Same Industry GroupHigh Similarity

Biological Product (except Diagnostic) Manufacturing

This U.S. industry comprises establishments primarily engaged in manufacturing vaccines, toxoids, bl...
325414Same Industry GroupHigh Similarity

Petrochemical Manufacturing

This industry comprises establishments primarily engaged in (1) manufacturing acyclic (i.e., aliphat...
325110Same SubsectorMedium Similarity

Industrial Gas Manufacturing

This industry comprises establishments primarily engaged in manufacturing industrial organic and ino...
325120Same SubsectorMedium Similarity

Synthetic Dye and Pigment Manufacturing

This industry comprises establishments primarily engaged in manufacturing synthetic organic and inor...
325130Same SubsectorMedium Similarity

Other Basic Inorganic Chemical Manufacturing

This industry comprises establishments primarily engaged in manufacturing basic inorganic chemicals ...
325180Same SubsectorMedium Similarity

Ethyl Alcohol Manufacturing

This U.S. industry comprises establishments primarily engaged in manufacturing nonpotable ethyl alco...
325193Same SubsectorMedium Similarity

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NAICS 325411 FAQ

Frequently Asked Questions

NAICS code 325411 covers Medicinal and Botanical Manufacturing. This U.S. industry comprises establishments primarily engaged in (1) manufacturing uncompounded medicinal chemicals and their derivatives (i.e., generally for use by pharmaceutical preparation manufacturers) and/or (2) grading, grinding, and milling uncompounded botanicals. Cross-References. Establishments primarily engaged in--

Recently Posted in Medicinal and Botanical Manufacturing

NAICS: 325411
New
DIBBS
REHYDRATION SALTS FThe contract is for Rehydration Salts F, a regulated medical product under FDA oversight, requiring confirmation of compliance with marketing requirements including registration, labeling, and Good Manufacturing Practices, though a 510(k) may not be required. The item has a non-extendable 24-month shelf life and must be marked in accordance with the latest edition of Medical Marking Standard No. 1 and MIL-STD-129, with packaging conforming to MIL-STD-2073-1E and DLA packaging requirements. The product is identified by NSN 6505-01-731-1574 and supplier part number 61436, provided by DRIP DROP HYDRATION INC. A total of two cases are to be delivered FOB destination within five days of contract award, with no variance allowed in quantity. Delivery is to Fort Stewart, Georgia, and shipping must occur via the fastest traceable means, excluding parcel post. The required delivery date is July 16, 2026, and the solicitation closes on July 21, 2026. The contract uses the DoD unit of issue and includes specific markings, packaging codes, and government-only identifiers. The contracting officer must submit an EBS referral for FDA product confirmation, including manufacturer and bidder details.
MEDICAL SUPPLY CHAIN PHARM FSA

POSTED

about 5 hours ago

DEADLINE

in 6 days
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NAICS: 325411
New
DIBBS
KETOROLAC TROMETHAMINEKetorolac Tromethamine Injection, USP 15 mg per mL in prefilled syringes, 24’s per unit, is being procured under contract SPE2DP-26-T-4143 for delivery to Fort Bragg, North Carolina, with a required delivery date of July 13, 2026, and a five-day delivery window. The item is identified by NSN 6505-01-666-2156 and NDC 76045-0107-10, manufactured by FRESENIUS KABI, LLC, and must comply with DLA’s Master List of Technical and Quality Requirements, including Packaging Requirement RP001 and Shelf-life requirement RS016, which mandates a non-extendable 24-month shelf life. All packaging must adhere to Medical Marking Standard No. 1, superseding MIL-STD-129, and units must be sealed in commercial containers that ensure protection from damage during transit. The product must be shipped by the fastest traceable means, excluding parcel post, and labeled according to current Hazard Communication Standards (29 C.F.R. 1910.1200), including OSHA-compliant Safety Data Sheets and labels, as mandated post-June 2015. The quantity is one unit of issue (PG), with zero variance permitted, and inspection and acceptance occur at the destination. Packaging and palletization must follow DLA specifications, and government identification must not appear on non-accepted supplies. The contract requires full compliance with all applicable DLA technical and quality requirements, which take precedence over ASTM D3951 or other general commercial standards.
MEDICAL SUPPLY CHAIN PHARM FSA

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about 5 hours ago

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in 6 days
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NAICS: 325411
New
DIBBS
BENZOCAINE AND MENTHOLBenzocaine and Menthol Lozenge, manufactured by RB Health US LLC and Reckitt Benckiser LLC, is a 15 mg benzocaine and 2.6 mg menthol oral pain reliever in honey lemon flavor, packaged in units of 16 lozenges, with a shelf life of 36 months that is non-extendable. The product must be stored at 20-25°C (68-77°F) and protected from humidity. All medical acquisitions require commercial packaging that ensures protection from damage or breakage, with each unit sealed in an appropriate container and shipped in exterior containers that guarantee safe, low-cost delivery to the destination. Material must be marked in accordance with Medical Marking Standard No. 1, which supersedes MIL-STD-129, and packaging must comply with DLA’s packaging requirements and palletization standards. The item is identified by NSN 6505017081449 and NDC 63824-0732-16, and is procured across five contract line items totaling 58 package units, each priced at $1.00 per unit, for total contract value of $58.00. Delivery is required within 20 days, FOB destination, with zero variance allowed in quantity, inspection and acceptance occurring at the delivery point. Shipments must be traceable, excluding parcel post, and sent to designated military logistics addresses at Fort Bragg, North Carolina, and Fort Stewart, Georgia. The solicitation, issued by the Department of Defense under contract SPE2DP-26-T-4113, has a response deadline of July 20, 2026, and requires compliance with all technical and quality requirements listed in the DLA Master List.
MEDICAL SUPPLY CHAIN PHARM FSA

POSTED

1 day ago

DEADLINE

in 5 days
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NAICS: 325411
New
DIBBS
ANALGESIC GEL, TOPICALThe contract specifies the procurement of an analgesic gel for topical use containing 5% menthol USP, supplied in 4 oz tubes with 144 tubes per case, classified as a flammable hazardous material requiring storage at 20–25°C (68–77°F) and protection from excessive heat or open flame. The item is identified by NSN 6505-01-658-7643 with a non-extendable shelf life of 24 months and must be packaged in commercial-grade containers that ensure protection from damage during transport, conforming to Medical Marking Standard No. 1 instead of MIL-STD-129. Shipment of the product must adhere to applicable hazard communication regulations, including the submission of Safety Data Sheets compliant with 29 C.F.R. 1910.1200 prior to award, and each shipment must include an accompanying SDS. Labels must meet OSHA’s revised Hazard Communication Standard aligned with the Globally Harmonized System, and supplier employees must be trained on these requirements. Packaging and transportation must comply with 49 CFR and ICAO regulations due to the flammable nature of the product, and all materials must be marked and documented in accordance with DLA’s hazardous material protocols, including electronic submission of SDS to DLA.MSDS@DLA.MIL. The contract is issued under solicitation SPE2DP-26-T-4115, requiring delivery within 20 days to Waterveciet, NY, and is managed by the Department of Defense’s Medical Supply Chain.
MEDICAL SUPPLY CHAIN PHARM FSA

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1 day ago

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NAICS: 325411
New
DIBBS
SUMATRIPTAN SUCCINATESumatriptan Succinate Tablets, 100 mg in bottles of 9 tablets, are procured under solicitation SPE2DP-26-T-4106 for acute treatment of migraines with or without aura in adults. The product must comply with strict storage requirements of 20 to 25°C (68 to 77°F), protected from light, and carries a non-extendable 24-month shelf life as a Type I (Code M) item. All packaging and marking must adhere to MIL-STD-2073-1E and MIL-STD-129, with palletization following DLA’s RP001 packaging standards and medical marking in alignment with Medical Marking Standard No. 1. The item is regulated by the FDA, requiring buyer referrals for confirmation before award. Three line items total 11 bottles, with delivery dates set for July 15–16, 2026, and a 20-day delivery window. Shipments are to be sent via traceable freight to designated military addresses in APO AE and Hampton, VA, with no parcel post permitted. The contract specifies zero variance in quantity, with inspection and acceptance occurring at destination. The manufacturer is Mylan Pharmaceuticals Inc. under NDC 00378-5632-59 and Golden State Medical Supply, Inc. under NDC 51407-0013-09, with packaging and labeling meeting all defense logistics agency technical and quality requirements referenced in the DLA Master List.
MEDICAL SUPPLY CHAIN PHARM FSA

POSTED

1 day ago

DEADLINE

in 5 days
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NAICS: 325411
New
DIBBS
ALBUMIN HUMANThe contract pertains to the procurement of Human Albumin 5% intravenous solution in 250ml flexible containers, supplied by Takeda Pharmaceuticals America, Inc., identified by NDC 00944-0495-05 and NSN 6505017029529. The item is required in multiple quantities across ten CLINs ranging from 2 to 12 packaging groups, totaling 100 packaging groups, with all deliveries mandated to be FOB destination within 20 days of the contract award. Strict packaging and marking requirements apply, mandating compliance with Medical Marking Standard No. 1, which supersedes MIL-STD-129, and adherence to DLA Packaging Requirements for Procurement (RP001), with all units sealed in commercial containers designed to prevent damage and ensure safe, low-cost transit. The product must be stored at room temperature not exceeding 30°C (86°F) and protected from freezing. A shelf life of 24 months, non-extendable, is enforced per RS016. The delivery destination is consistent across all CLINs: Nellis Air Force Base, Nevada, with shipment required via traceable means—parcel post is expressly prohibited. Inspection and acceptance occur at the destination, with zero tolerance for quantity variance. All documentation, packaging, and marking must align with the latest DLA standards, and the supplier must ensure the material is properly identified and traceable through the supply chain.
MEDICAL SUPPLY CHAIN PHARM FSA

POSTED

2 days ago

DEADLINE

in 5 days
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NAICS: 325411
Closed
DIBBS
NIRMATRELVIR AND RIThe contract pertains to the procurement of Nirmatrelvir and Ritonavir tablets, marketed as Paxlovid, supplied by Pfizer Inc under part number NDC00069-5321-30, with a national stock number of 6505017227590. Each unit consists of a box containing ten blister cards, with each blister card providing one full daily dose comprising two 150 mg Nirmatrelvir tablets and one 100 mg Ritonavir tablet, sufficient for a five-day treatment course at two doses per day. The item is classified as a Type I (Code Q) pharmaceutical with a non-extendable shelf life of 36 months and is regulated by the FDA. The unit of issue is a box of ten, and delivery must be completed within 20 days of award to the designated destination: N23197 USNS CARL BRASHEAR T-AKE 7, UNIT 100204 BOX 1, FPO AP 96661. The contract specifies FOB destination terms, with zero tolerance for quantity variance, and requires inspection and acceptance at the delivery point. All packaging and marking must conform to commercial standards and comply with Medical Marking Standard No. 1, which supersedes MIL-STD-129, with palletization aligned with DLA Packaging Requirements for Procurement (RP001). Packaging must ensure the product is sealed in unit containers that safeguard against damage during transit and packed in suitable commercial shipping containers appropriate for safe and economical delivery by common carriers. The solicitation incorporates specific technical and quality requirements listed in the DLA Master List of Technical and Quality Requirements and mandates compliance with the Buy American Act, the Berry Amendment, and DFARS 252.225-7001. The contract includes critical cybersecurity and compliance clauses such as Safeguarding Covered Defense Information, Cyber Incident Reporting, Prohibition on Covered Telecommunications Equipment, and requirements for combating trafficking in persons, employment eligibility verification, and sustainable products, all under deviation 2026-00038. Offerors must be registered in SAM, represent their small business status accurately, and comply with all applicable FAR and DFARS clauses. The solicitation is a small business set-aside under NAICS code 325411, with quotes submitted exclusively via the DLA Internet Bid Board System by
MEDICAL SUPPLY CHAIN PHARM FSA

POSTED

2 days ago

CLOSED

2 days ago
View Details
NAICS: 325411
Awarded
Federal
65--Pharm Manuf/Distr Div - FSAThe contract titled 65--Pharm Manuf/Distr Div - FSA is awarded under solicitation number SPE2D225R00100006 and was posted on July 13, 2026. It falls under NAICS code 325411, which pertains to pharmaceutical and medicine manufacturing, and is managed by the Defense Logistics Agency Troop Support, specifically through its office in Philadelphia, Pennsylvania, with a zip code of 19111. The primary point of contact for this contract is Jason C. Wray, who can be reached via email at Jason.Wray@dla.mil or by phone at (445) 737-6304. The place of performance has not been specified, indicating flexibility or ongoing determination of delivery locations. This award notice does not indicate a specific set-aside type, meaning it is open to general competition without restrictions based on small business or other designation categories. The contract relates to the manufacture or distribution of pharmaceutical products in support of Department of Defense requirements.
DLA Troop Support

POSTED

2 days ago

DEADLINE

N/A
View Details
NAICS: 325411
New
DIBBS
BENZOCAINE AND MENTHOLThe contract solicits 4 packaging units of Cepacol Extra Strength Sore Throat Honey Lemon Lozenges, each containing 16 lozenges with 15 mg benzocaine and 2.6 mg menthol, identified by NSN 6505-01-708-1449 and NDC 63824-0732-16. The product must be stored at 20–25°C (68–77°F) and protected from humidity, with a non-extendable shelf life of 36 months as a TYPE I (CODE Q) item. All units must be individually sealed in commercial packaging that protects against damage or breakage, and shipped in commercial exterior containers ensuring safe, cost-effective delivery to Fort Bragg, NC, under FOB Destination terms. Medical Marking Standard No. 1 supersedes MIL-STD-129 for all labeling, and palletization must comply with DLA Packaging Requirements for Procurement. Delivery is required within five days of award, with inspection and acceptance occurring at the destination. The item falls under NAICS code 325411 and is subject to the Buy American Act, Berry Amendment, and DFARS 252.225-7001, requiring domestic sourcing. Contractors must comply with cybersecurity requirements including FAR 52.204-7012, NIST SP 800-171, and prohibitions on covered telecommunications equipment. Safety Data Sheets must be submitted if applicable, and all offerors must maintain active SAM registration. The contract includes clauses on whistleblower rights, information safeguarding, trafficking in persons, arbitration restrictions, and prohibitions on mandatory confidentiality agreements. Quotations must be submitted via email by July 20, 2026, and while the solicitation is not a small business set-aside, HUBZone price preferences may apply. The point of contact is James Foggie, and invoice and receiving reports must be processed through Wide Area Workflow unless an exception applies.
MEDICAL SUPPLY CHAIN PHARM FSA

POSTED

3 days ago

DEADLINE

in 5 days
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NAICS: 325411
New
DIBBS
SUMATRIPTAN SUCCINATESumatriptan Succinate Tablets, 100 mg in bottles of nine tablets, are being procured under solicitation SPE2DP-26-T-4080 for delivery to APO AE 09094-3219, with a required delivery date of July 14, 2026, and a lead time of 20 days. The item, identified by NSN 6505-01-727-8704, is intended for the acute treatment of migraine with or without aura in adults and must be stored at 20 to 25°C (68 to 77°F), protected from light, and maintained under USP controlled room temperature conditions. The contract mandates a strict shelf life of 24 months, non-extendable, in compliance with RS001 for a Type I (Code M) medical item, and requires labeling and marking in accordance with the latest edition of Medical Marking Standard No. 1 and MIL-STD-129, with packaging conforming to MIL-STD-2073-1E, Packing Level B, and DLA Packaging Requirements for Procurement (RP001). The item must be sourced from domestic origin unless otherwise indicated, and the supplier must provide the manufacturer’s part number, NDC 00378-5632-59 for Mylan Pharmaceuticals Inc. or NDC 51407-0013-09 for Golden State Medical Supply, Inc. Technical and quality requirements referenced by R or I numbers are governed by the DLA Master List of Technical and Quality Requirements, with additional compliance required for the removal of government identification from non-accepted supplies and covered defense information. The solicitation prohibits the use of additive manufacturing for this item and requires submission of a safety data sheet prior to award; failure to meet either requirement results in immediate disqualification. Contract administration requires the use of the Wide Area WorkFlow system for invoicing and receiving reports, with the contractor obligated to maintain current registration in the System for Award Management and provide commercial and government entity codes. The contract incorporates numerous Federal Acquisition Regulation clauses addressing equal opportunity, trafficking in persons, employment eligibility verification, sustainable products, hazardous materials identification, cybersecurity, changes, unenforceability of obligations, accelerated payments to small business subcontractors, safeguarding information systems, transportation by sea, disclosure of information, whistleblower rights, and notification
MEDICAL SUPPLY CHAIN PHARM FSA

POSTED

3 days ago

DEADLINE

in 5 days
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NAICS: 325411
New
Federal
Active Pharmaceutical Ingredient (API) SupplyThe contract is for the supply of bulk active pharmaceutical ingredients used in the final formulation of drugs, categorized under NAICS code 325411 for pharmaceutical and biological product manufacturing. It is structured as a subcontract and is linked to the NAC Federal Supply Schedule 36F797 under the Department of Veterans Affairs. The opportunity was posted on July 10, 2026, and while no specific place of performance or point of contact is provided, the procurement is intended to support the VA’s pharmaceutical needs through reliable sourcing of essential drug components. The agreement is part of a broader federal supply framework designed to ensure consistent, compliant delivery of critical medicinal ingredients without a specified set-aside classification.
Nac Federal Supply Schedule (36F797)

POSTED

5 days ago

DEADLINE

N/A
View Details
NAICS: 325411
Closed
DIBBS
PSYLLIUM HYDROPHILIThe contract specifies the procurement of Psyllium Hydrophilic Mucilloid in 12 gm packets, each containing 25 mg of potassium and 5 mg of sodium, packaged in units of 30 packets per pack. The item is regulated by the FDA and must be supplied with the manufacturer’s part number NDC37000-0740-87 from The Procter & Gamble Distributing LLC. It has a non-extendable shelf life of 24 months and must comply with all technical and quality requirements listed in the DLA Master List. Packaging and marking must strictly follow the latest edition of Medical Marking Standard No. 1, superseding MIL-STD-129, and all packaging must be commercial-grade, sealed, and able to protect the contents during transit. The unit of issue is a package of 30s, and the delivery is FOB destination within five days of award, with no variance allowed in quantity. All shipments must be sent via the fastest traceable means, excluding parcel post, to the specified delivery point at MCJB Kāneʻohe Bay, Hawaii. The item is subject to DLA packaging and distribution standards, including palletization and special marking requirements, and must be accompanied by accurate supplier and manufacturer information for FDA referral through EBS. The contract is issued under solicitation SPE2DP-26-T-4068 with a required delivery date of January 30, 2026.
MEDICAL SUPPLY CHAIN PHARM FSA

POSTED

6 days ago

CLOSED

about 5 hours ago
View Details

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