ARPA-H Lineage Topic

The ARPA-H Lineage Topic solicitation, identified as ARPA-H 05, is a total small business set-aside under NAICS code 541715. The program is designed to support small businesses and startups in the advancement, commercialization, and translation of technologies originating from ARPA-H funded efforts. By providing an off-ramp for technology development, the initiative helps firms explore secondary applications and achieve self-sufficiency. The solicitation is open for responses until September 30, 2027, and covers Phase I, Direct-to-Phase II, and Fast-Track application types for both SBIR and STTR programs. The contract structure includes a phased performance period with Phase I lasting 24 months and Phase II or Sequential Phase II lasting 36 months, with potential service extensions up to 6 months. Financial support includes Technical and Business Assistance (TABA) requests of up to 6,500 dollars for Phase I and 50,000 dollars for Phase II. Proposals are evaluated based on technical merit, novelty, team expertise, and the path to health impact, with a strong emphasis on transformative advancements rather than incremental research. Applicants must submit a solution summary, a cost proposal, a task description document, and a Gantt chart, and may be required to deliver an oral technical presentation. Compliance requirements include adherence to Revised 508 Standards for information and communication technology and the use of the Department of Treasury Invoice Processing Platform for electronic payments. The contract incorporates various FAR and HHSAR clauses, including deviations regarding the Buy American Act, protection of human subjects, and the prohibition of certain internal confidentiality agreements. Key personnel must be clearly identified and documented to ensure project management and technical success.