This Government Contract opportunity from Environmental Protection Agency was posted on March 28, 2006. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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R--Development of Statistically Based Quantitative Structure-Toxicity Relationship (QSTR) Models for Predicting the Sub-Chronic Toxicity Benchmarks for a Variety of Chemicals

Awarded

PR-CI-05-10965Federal

Submission Closed03/10/2006, 12:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541715

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Federal

NextGen IACMAC Industry Day

Solicitation # FA807527R0001-NextGen_IACMAC_Industry_Day

The NextGen Information Analysis Centers Multiple Award Contract (NextGen IACMAC) is an Indefinite Delivery Indefinite Quantity (IDIQ) research and development marketplace valued at over 80 billion dollars. Managed by the Office of Assistant Secretary of War for Critical Technologies and the 774ESS, this competitive ecosystem is designed to connect the government with industry, academia, laboratories, and non-traditional innovators to solve complex technology problems. The program follows a lifecycle of discovery, competition, development, demonstration, and transition, focusing on key technology areas including Applied Artificial Intelligence, Biomanufacturing, Confused Logistics Technologies, Scaled Directed Energy, and Scaled Hypersonics. The government is currently hosting an Industry Day on October 30, 2026, at the Mark Center in Alexandria, Virginia, to discuss technical priorities, the acquisition strategy, and the upcoming requirement. This event serves as a planning and informational session to gather industry feedback regarding Sources Sought Notice FA807527R0001 and is not a formal Request for Proposal. Interested parties must register by October 26, 2026, and obtain a Visit Access Request for attendance. Primary points of contact for the initiative include Rebecca Robeson and Kelly Lybolt.

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Cryptographic Module Engineering (NSA HAD)This subcontract opportunity with the Naval Air Warfare Center Air Division involves the development and integration of modular embedded cryptographic modules for Department of Defense tactical communications projects. The selected provider will engineer modules that adhere to NSA High Assurance Device requirements and ensure seamless integration with DoD battery-backed key storage systems. The scope of work requires the implementation of Risk Management Framework controls and Zero Trust architecture to deliver a fully certified embedded cryptographic module. Interested parties must respond by November 23, 2026, under NAICS code 541715.

Naval Air Warfare Center Air Division

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AI/ML and Super Intelligence ConsultingThis subcontract for AI/ML and Super Intelligence Consulting supports prime contractors on TSA Horizon25 projects under the Department of Homeland Security. The scope of work involves the development of advanced machine learning models for predictive analytics, the implementation of autonomous agents, and the utilization of High-Performance Computing to deliver AI-driven analytical tools. A critical component of the engagement is the strict adherence to AI safety standards, specifically NIST AI 100-1 and NIST AI 100-2 regarding Adversarial ML. The performance of these services is centered in Springfield, Virginia, under NAICS code 541715.

Transportation Security Administration

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Checkpoint Visualization and Digital Twin DevelopmentThe Checkpoint Visualization and Digital Twin Development subcontract, issued by the Transportation Security Administration under the Department of Homeland Security, focuses on creating digital twin environments and visualization tools for prime contractors on TSA Horizon25 projects. The primary objective is to detect operational bottlenecks and simulate passenger flow through the development of 3D digital twins. This will be achieved by implementing specialized detection algorithms and visualizing real-time operational data leveraging computer vision, edge analytics, and sensor technologies. The project requires strict adherence to NIST AI 100-1 and NIST AI 100-2 standards to ensure the secure and ethical deployment of artificial intelligence. The final deliverable is a comprehensive digital twin visualization platform. Performance for this contract is centered in Springfield, Virginia, and falls under NAICS code 541715.

Transportation Security Administration

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AI Research & PrototypingThe AI Research and Prototyping subcontract supports Department of the Air Force CDAO projects by developing research products, functional prototypes, and test results for new AI environment capabilities. The scope of work includes conducting research on AI environment architectures and executing tests for new AI tools to create operational capabilities for prime contractors. Due to the sensitive nature of the work, a TS/SCI clearance is required for personnel. The project is managed under the Department of Defense via the FA7014 Afdw Pk agency, with a response deadline of November 2, 2026. Final deliverables consist of comprehensive research reports, functional prototypes, and validated test results.

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AI/ML Model Development & Algorithmic DesignThis subcontract focuses on the design, development, fine-tuning, and testing of advanced AI/ML models to support prime contractors on Department of the Air Force CDAO projects. The scope of work involves applying supervised, unsupervised, and reinforcement learning, deep neural networks, and probabilistic modeling. Technical execution requires the use of accelerated computing resources, such as GPUs and TPUs, alongside industry-standard frameworks including PyTorch and TensorFlow to deliver validated algorithmic capabilities. Due to the sensitive nature of the Department of Defense projects, all personnel must possess a TS/SCI security clearance. The contract is categorized under NAICS code 541715 and is associated with the agency FA7014 Afdw Pk. Interested parties should note the response deadline of November 2, 2026.

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Historical Research & Archival ServicesThis subcontract for Historical Research and Archival Services supports prime contractors on DPAA projects under the Department of Defense, specifically through Washington Headquarters Services. The selected provider will utilize professional historical expertise and government record access to perform complex research aimed at contextualizing loss incidents. Key responsibilities include conducting archival research, developing detailed case narratives of individuals or conflicts, and generating targeted lists of potential recovery locations based on historical evidence. The work is designated under NAICS code 541715 and will be performed in Alexandria, Virginia. Interested parties must submit their responses by November 9, 2026, at 3:00 PM. The primary deliverables for this engagement are the completed case narratives and the identified lists of potential recovery sites.

Washington Headquarters Services

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Common Autonomous Multi-Domain Launcher (CAML)-Lite Prototype Effort

Solicitation # W50RAJ27CAML_LITE

The Common Autonomous Multi-Domain Launcher (CAML)-Lite Prototype Effort is a competitive procurement conducted under 10 U.S.C. section 4022 Other Transaction Authority to develop a mobile, optionally manned, autonomous launcher for cross-domain offensive and defensive fires. The program is structured in two phases, beginning with Phase 1, which requires a prototype demonstration at Talisman Sabre 2027 in August 2027. This initial phase includes a priced option for the acquisition of additional prototype units, New Equipment Training, and Contractor Logistics Support. Phase 2 focuses on prototype maturation and integration into a common CAML architecture. The government seeks solutions that utilize a Modular Open Systems Approach to ensure interchangeable modules and autonomous munition resupply with minimal human intervention. The procurement process begins with the submission of a Solutions Brief, with a deadline of October 26, 2026. The government will evaluate these briefs based on technical soundness, credibility in addressing objectives, and the feasibility of the maturation path to select the most meritorious respondents for a subsequent Request for Prototype Proposal. Award for Phase 1 is expected by December 18, 2026. Selected performers must assume full responsibility for international logistics and compliance for transporting systems to Australia. Funding for the demonstration will be provided at initial award, though performer investment is required and may positively influence selection. Final acceptance of the effort is contingent upon successful performance verification, cybersecurity Authority to Operate, and government approval of the Technical Data Package.

W6DV Peo M & S Redstone

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RTI Connext Site License Renewal

Solicitation # 80TECH27QA010

NASA It Procurement Office

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Timed Emitters Transmitting Highly Energized Radiation (TETHER)

Solicitation # N00173-27-RFI-EN01

The Naval Research Laboratory Space Systems Development Division is issuing a sources-sought Request for Information under solicitation N00173-27-RFI-EN01 for the Timed Emitters Transmitting Highly Energized Radiation TETHER effort. As a follow-on to the Target Accuracy Precision Emitters program, this initiative focuses on space-to-ground research to provide precise timing, frequency, and geodesy support for the warfighter. The primary objective is to advance high-precision timing and frequency technologies to achieve femtosecond-level accuracy using large apertures and complex clock ensembles, including atomic clocks, hydrogen masers, and atomic fountain clocks. Key technical requirements include delivering certified timing with accuracy of less than 2 nanoseconds and maintaining picosecond precision with 3 parts per trillion stability. Performance will occur at NRL facilities, government field sites, and other locations within and outside the Continental United States. The government is seeking capabilities statements from interested industry parties, including both large and small businesses, to gauge interest and experience. Key personnel must possess a final DoD-granted Top Secret security clearance with SCI eligibility and a minimum of 10 years of experience in high-precision RF generation facilities. Additionally, certain staff must meet DoD 8140 series cybersecurity workforce qualifications. Responses are due by November 9, 2026, and will be used to inform future solicitation planning and potential small business set-aside decisions.

Naval Research Laboratory

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Protein Palace Proposers Day

Solicitation # DARPA-SN-27-01

The Defense Advanced Research Projects Agency (DARPA) is initiating the Protein Palace program to develop a universal, tunable protein purification platform. This initiative aims to replace the traditional lock-and-key paradigm with a system capable of purifying multiple proteins from a single system by leveraging unique physicochemical characteristics to improve specificity, generalizability, and scalability in biomanufacturing. The program is structured into two distinct phases: a 24-month Phase 1 focused on proving feasibility and specificity by separating eight different proteins, followed by an 18-month Phase 2 focused on increasing throughput and volume, demonstrated on two additional proteins that are difficult to purify using current state-of-the-art methods. To support this effort, DARPA is hosting an in-person Proposers Day on November 17, 2026, from 9:00 a.m. to 4:00 p.m. ET at the Executive Conference Center in Arlington, Virginia. Interested parties must register by November 9, 2026, and provide government-issued photo identification for entry. While the current Special Notice DARPA-SN-27-01 is for information and planning purposes and does not constitute a formal solicitation, DARPA anticipates releasing the full solicitation on sam.gov prior to the event. The Proposers Day will be held at the unclassified level, and any presented materials must be suitable for unlimited public release.

Defense Advanced Research Projects Agcy

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HYDROSPHERE, BIOSPHERE, & GEOPHYSICS (HBG) SUPPORT SERVICES II - FINAL REQUEST FOR PROPOSAL (FRFP)

Solicitation # 80GSFC27R0015

The National Aeronautics and Space Administration Goddard Space Flight Center is soliciting proposals for the Hydrosphere, Biosphere, and Geophysics (HBG) Support Services II contract, under solicitation number 80GSFC27R0015. This small business set-aside is a hybrid Indefinite Delivery Indefinite Quantity (IDIQ) contract with a five-year effective ordering period. The contract allows for the issuance of both Cost Plus Fixed Fee (CPFF) and Firm-Fixed Price (FFP) task orders to support science research and computing activities across various laboratories, including the Cryospheric Sciences, Ocean Ecology, Hydrological Sciences, Biospheric Sciences, Geodesy and Geophysics, and the Terrestrial Information Systems Laboratory. The primary objective is to develop and apply space, field-deployed, and laboratory-based technologies to address societal issues related to water resources, ecosystems, sea level change, and the Earth's magnetic and gravity fields. The scope of work encompasses scientific modeling, simulation, data assimilation, satellite instrument performance analysis, and the planning and execution of field campaigns. Performance will occur at the Goddard Space Flight Center and the contractor's facilities, with acceptance managed by the Contracting Officer or a designated representative. Award selection will be based on a tradeoff approach, prioritizing Mission Suitability as the most important factor, followed by Cost and Past Performance. Proposals must be submitted in four volumes, including a numerically scored Mission Suitability volume and a detailed Cost volume. Additionally, the contractor must adhere to strict security requirements, including the provision of a Cyber Supply Chain Risk Management plan and compliance with NDAA Section 889 regarding telecommunications and surveillance equipment.

NASA Goddard Space Flight Center

POSTED

1 day ago

DEADLINE

in about 1 month

AI Contract Overview

The U.S. Environmental Protection Agency's National Homeland Security Research Center is seeking a contractor to develop predictive models that estimate sub-chronic toxicity benchmarks for various chemicals. These models will be based on experimental sub-chronic toxicity data such as LOAEL, BMD, or BMDL10, and will utilize Quantitative Structure-Toxicity Relationships (QSTRs) to assess toxicity through both oral and inhalation exposure routes. The contract requires the creation of separate QSTR models tailored to each toxicity benchmark and route of exposure. The solicitation, issued by the Cincinnati Acquisition Division of the EPA, aims to support the development of statistically based QSTR models to improve the prediction of chemical toxicity. This initiative is central to enhancing risk assessment capabilities by providing more reliable toxicity estimates for chemicals under different exposure conditions. The contract was posted as a presolicitation in July 2005 and does not indicate any set-aside status or specific NAICS code. The work is managed by an EPA office based in Cincinnati, Ohio.