Bioinformatic Analysis – Differential Expression and Functional Enrichment

The contract requires the performance of bioinformatic analysis focused on differential gene expression across developmental stages and genders using established tools such as DESeq2 and edgeR. The analysis must comprehensively compare gene expression profiles to identify significantly regulated transcripts under varying biological conditions. Following differential expression, functional enrichment analyses are mandated using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA) to interpret biological meaning, pathway involvement, and regulatory networks linked to the observed gene expression changes. The work demands rigorous statistical validation and clear interpretation of results to support biological insights. The contract is classified as a subcontract under NAICS code 541690 and is issued by the FDA Office of Acquisition and Grant Services under the Department of Health and Human Services. The proposal response is due by August 10, 2026, with the work to be performed in Jefferson, Arkansas, ZIP 72079. The solicitation was posted on August 3, 2026, and interested parties must submit their bids through the official SAM.gov portal. No set-aside provisions apply, and the contract does not specify point of contact details beyond the public posting.