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This Combined Synopsis/Solicitation opportunity from Department Of Health And Human Services was posted on August 10, 2023. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

Comprehensive toxicity analysis of individual ENDS

Closed
FDA-RFP-75F40123R00115Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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General Info

Agency

Department Of Health And Human Services → FDA Office Of Acq Grant Svcs

NAICS

541690 - Other Scientific and Technical Consulting Services

Place of Performance

MD, USA

Set-Aside

NONE

Documents

1

FDA Solicitation 75F40123R00115 - Comprehensive Toxicity Analysis of Individual ENDS

PDF, High priority: read this firstrfp
High

AI Contract Breakdown

Uniform Contract Format

Contract not broken down yet

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Timeline

2 updates
PhaseClosed
Posted

Combined Synopsis

Deadline changed

Response deadline changed from Aug 4, 2023 to Aug 11, 2023.

Deadline changed

Response deadline changed from Aug 11, 2023 to Aug 21, 2023.

Response Deadline

Deadline has passed

Submission Closed

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → FDA Office Of Acq Grant Svcs
Contacts2 people available
OfficeBeltsville, MD, 20705, USA
Organization / AgencyDepartment Of Health And Human Services → FDA Office Of Acq Grant Svcs
Office AddressBeltsville, MD, 20705, USA
Contacts
Lisa Jackson
contact@example.gov
+1 (555) 000-0000
Erika Eam
contact@example.gov

Full Description

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The Contractor shall investigate the toxicity of 125 flavor ingredient chemicals alone and combined with metal using high throughput assays. The FDA will produce a final library of 125 flavor ingredient chemicals based on the predicted propensity of flavor ingredient chemicals to interact with metals. The Contractor shall perform cytotoxicity assays and measurements of cytokine levels in the supernatant to determine appropriate sublethal concentrations of flavor ingredient chemicals and metals to use in subsequent mutagenic and genotoxic assays, which consist of assays in cells lines and in bacteria. The Contractor shall determine based on measurables of the mutagenic and genotoxic experiments a list of 20 flavor ingredient chemicals and 20 flavor-metal combinations and their concentrations to be tested in the reconstructed human lung tissue model to measure the effects on metabolism, membrane integrity, cell viability, inflammation, and DNA damage. The Contractor shall perform all data analyses, provide FDA all of the raw data, and write study reports.

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Same awarding agency

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