Custom Generation of Conditional Knock In Mouse and Delivery

This is a combined synopsis/solicitation, to procure Custom Generation of conditional Knock In mouse and Delivery, in accordance with the format of FAR Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation, quotes are being not requested and a written solicitation will not be issued. This procurement is being issued as a Notice of intent (NOI8255) This solicitation and its incorporated provisions and clauses are those in effect through Federal Acquisition Circular FAC-23 January 25, 2008. This acquisition will be processed under Simplified Acquisition Procedures (SAP) and is a small business set-aside. The North American Industry Classification System Code Number 112990 and the small business size standard $0.75 dollars. The National Institute of Allergy and Infectious Diseases (NIAID) intend to procure Custom Generation and delivery of Genetically Modified Mouse Models from Taconic/Artemis. The vendor must have a proven record of success with conditional gene targeting technologies and provide the CRE-LOX, CreER, and FLP-FRT systems to allow for further temporal or tissue specific gene modifications in vivo. The vendor must create the targeting vector incorporating these conditional knockout systems to the investigator's specifications and transfect the vector into C57BL6 ES cells. Isolated targeted clones must be validated with both internal and external probes, and a minimum of 2 clones must be injected into diploid blastocysts. Chimeras must be crossbred to generate heterozygous conditional knockout mice and the selection marker must be deleted in vivo with the FLP-FRT system. The mouse model must be fully licensed to customer with positive/negative selection (PNS) and isogenic DNA patents. The expected time line for generation of heterozygous mice should be 46 weeks. The following Federal Acquisition Regulations provisions and clauses apply to the acquisition: FAR 52.225-3Buy American Act; FAR 52.212-1 Instructions to Offerors Commercial Items; Far 52.212-3 Offeror Representation and Certifications Commercial Items; Far 52.212-4 Contract Terms and Conditions Commercial Items; FAR 52.212-5 Contract Terms and Conditions Required to Implement Statues or Executive Orders Commercial Items; FAR 52.212-2 Evaluation-Commercial Items; and FAR 52.406-7 Central Contractor Registration (2003). A completed copy of provisions at FAR 52.212-3 Offerors Representation and Certifications Commercial Items must be included which can be found at online Representations and Certifications Application (ORCA) https://orca.bpn.gov/. (B) (1) By submission of an offer, the Offeror acknowledges the requirement that a prospective awardees shall be registered in the CCR database prior to award, during performance, and through final payment of any contract, basic agreement, basic ordering agreement, or blanket purchasing agreement resulting from this solicitation. The CCR website is http://www/ccr.dllis.dlamil Copies of the aforementioned clauses are available upon request by telephone to Diane Jeffers at (301)-405-6684. All responsible sources may submit offers that shall be considered by this agency. Offers must be submit no later than 5:00 p.m Eastern Standard Time (EST), June 23, 2008. For delivery though the U.S Postal Service, the address is NIH/NIAID/AMOB, 10401 Fernwood Road, Room 2NE70F, Bethesda MD 20817-4811. Requests for information concerning this requirement shall be addressed to Diane Jeffers at (301) 402-6684. Collect calls will not be accepted.