Cyprotex Contract - Development of a 2D Human Neural Network Formation Assay (To

The Food and Drug Administration is seeking external contract research support to develop a novel 2D human neural network formation assay within its high-priority research area of developmental neurotoxicity. This effort aims to advance in vitro methods for assessing the neurotoxic effects of substances during critical stages of nervous system development, aligning with the FDA’s goal to improve chemical safety evaluation through human-relevant models. The work will involve designing, optimizing, and validating a scientifically robust assay platform that accurately recapitulates key aspects of human neural network formation and function, with potential application in regulatory decision-making. The contract opportunity is classified under NAICS code 541990 for other scientific and technical consulting services and is posted as a forecast with no set-aside designation. The place of performance and specific funding details are not yet defined, and the contracting officer position remains listed as to be determined. All inquiries and communications should be directed to the HFP Acquisition Liaison at hfpacquisitions@fda.hhs.gov. This initiative underscores the FDA’s commitment to modernizing toxicological testing by integrating human-derived cellular systems to better predict and prevent developmental neurotoxicity.