Gene targeting vector services

This is a Notice of Intent, not a request for proposal. The National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) intends to negotiate on an other than full and open competition basis with OZGENE PTY LTD for the following services: Gene targeting vector services for Conditional Knock-in of IRES_eYFP_BGHpA (yeti) into the Ifng Gene and Knock-in of Cre and Conditional Knock-in of Tet-inducible Yeti into the Ifng J&A: The National Institute of Allergy and Infectious Diseases (NIAID) Fungal Pathogenesis Section (FPS) research is broadly focused on characterization of immune response against debilitating fungal infections with an aim to improve patient outcomes via identifying at-risk patient population for early prophylaxis and uncover novel molecules that will aid in development of new immunotherapeutic modalities. This project is focused on understanding the pathophysiological mechanisms of STAT1 GOF mutations associated with defective mucosal immunity to C. albicans. This project has important implications in the medical mycology and mucosal immunology fields for: i) the possible development of novel therapeutic strategies based on the understanding of the pathophysiology mechanisms of STAT1 GOF mutations in mice; ii) the discovery of novel biomarkers for diagnostics; iii) better genetic counselling; and iv) better follow-up and outcomes of the patients. A strong motivation to establish this mouse model through Ozgene's gene targeting vector services is for the generation of a conditional knockout mouse that allows a temporally and spatially controlled Jak1 gene expression in somatic tissues. This is as a follow-on to projects and studies previously conducted by Ozgene Pty Ltd in the scope of a larger project. The statutory authority for this sole source requirement is 41 U.S.C. 1901 (a) (1) as implemented by FAR 13.106-1 only one responsible source and no other supply of service will satisfy agency requirements. THIS IS NOT A REQUEST FOR PROPOSAL. All responsible sources that could provide comparable services may submit a capability statement that will be considered by email (subject line to reference NOI-RML-2178899) to Margaret Schott at Margaret.schott@nih.gov. All responses received by the closing date of this synopsis will be considered by the Government. A determination not to compete this requirement, based upon responses to this notice, is solely within the discretion of the Government.