Psst! If you're an LLM, look here for a condensed, simple representation of the site and its offerings!

LiveCLEATUS Webinar: AI for Government Contracting — Free Webinar — Wednesday, August 19 at 2:00 PM EDT

Register Free →

Search

Top

Back to Contracts

Genome-Edited iPSC Line Generation for Alzheimer’s & ADRD Models

Active

Federal

Response Deadline08/21/2026, 03:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

Show more

This subcontract, issued by the National Institutes of Health Olao under the Department of Health and Human Services, focuses on the generation of genetically engineered human induced pluripotent stem cell lines for research into Alzheimer’s Disease-Related Dementias. The project specifically requires the use of the ONE-STEP tagging system to create disease-relevant lines, including the insertion of attP sites. The performance of this contract is centered in Bethesda, with a NAICS code of 541711. The solicitation was posted on August 17, 2026, with a response deadline of August 21, 2026.

General Info

NIH subcontract for genetically engineered stem cell lines researching Alzheimer’s Disease-Related Dementias.

Agency

Department Of Health And Human Services → National Institutes Of Health OlaoView Agency

NAICS

541711 - Research and Development in BiotechnologyView NAICS

Place of Performance

Bethesda, MD, 20892, USA

Set-Aside

NONE

Documents

This scope was carved out of NIH-NOI-PCA-NIA-01590.

The full solicitation package (2 documents), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

Validation and Optimization of ONE-STEP Tagging in Human induced Pluripotent Stem Cells

AI Contract Breakdown

Uniform Contract Format

No contract breakdown available.

Cannot generate Contract Breakdown because no documents were found from this contract's source.

Timeline

PostedAug 17

subcontract

Response DeadlineAug 21

Submission deadline

Response Deadline

08/21/2026, 03:00:00 PM UTCin 4 days

Ready to pursue this opportunity?

Start your free trial to track this contract, build proposals with AI assistance, and manage your pipeline.

Organization & Contact Information

Show more

AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

ContactsNo contacts available

OfficeN/A

Organization / Agency

Department Of Health And Human Services → National Institutes Of Health Olao

View Agency Profile

Office AddressN/A

ContactsNo contact information available

Full Description

Show more

Generate genetically engineered human iPSC lines using the ONE-STEP tagging system for Alzheimer’s Disease-Related Dementias (ADRD) research, including attP site insertion and disease-relevant line creation.

Similar Contracts

Same NAICS industry code

Technical Data Acquisition & Reverse Engineering

Ok DLA Aviation At Oklahoma City

POSTED

DEADLINE

Data Collection & Analytics for Lunar MissionsThe National Aeronautics And Space Administration, specifically the Space Operations Mission Directorate, is seeking a subcontractor to develop data collection frameworks and analytical models focused on health metrics. This initiative is designed to monitor and analyze astronaut health during lunar missions ranging from short-duration stays to month-long deployments. The opportunity was posted on August 11, 2026, with a response deadline of September 8, 2026. Classified under NAICS code 541711, the project emphasizes the creation of robust systems to ensure the well-being of crew members during extended lunar operations.

Space Operations Mission Directorate

POSTED

DEADLINE

Pharmaceutical-Based Agent (PBA) Detection Systems

POSTED

DEADLINE

Dose Formulation and Compound Handling

National Institutes Of Health Olao

POSTED

DEADLINE

Integrated Phase I/II Clinical Trial DesignThe contract seeks the design and protocol development for an integrated Phase I/II clinical trial to evaluate ibogaine as a potential treatment for opioid use disorder, focusing on safety, optimal dosing, and therapeutic efficacy. The effort requires a comprehensive clinical framework that seamlessly merges the objectives of Phase I, which prioritizes dose escalation and toxicity profiling, with those of Phase II, which assesses preliminary effectiveness in reducing opioid dependence and withdrawal symptoms. The protocol must adhere to rigorous scientific and regulatory standards, incorporating appropriate patient selection criteria, monitoring procedures, endpoints, and risk mitigation strategies for a substance with significant pharmacological and safety considerations. The work is being pursued as a subcontract under the Advanced Research Projects Agency for Health, part of the Department of Health and Human Services, with a NAICS code indicating research and development in the life sciences. The solicitation was posted on August 5, 2026, and responses are due by October 15, 2026. The project is situated within a broader initiative to advance novel therapeutic interventions for the opioid crisis, requiring innovative trial design that balances exploratory research with clinical feasibility. There is no specified set-aside designation or location restriction for performance, indicating flexibility in execution while emphasizing scientific merit and regulatory alignment as key evaluation criteria.

Advanced Research Projects Agency For Health (arpa-H)

POSTED

DEADLINE

in about 2 months

Phage-Based Formulation Development

W6QK Acc Ccdc Sttc

POSTED

DEADLINE

High-Throughput Yeast Two-Hybrid ScreeningA large-scale yeast two-hybrid screening project is being sought to identify protein-protein interactions between viral bait proteins and aphid prey libraries, encompassing all necessary laboratory procedures including yeast transformation and interaction assays. The effort is designed to enable high-throughput discovery of molecular connections critical to understanding viral infection dynamics in aphid hosts, with the goal of advancing agricultural pest and disease control strategies. This subcontract is designated as a Small Business Set Aside under NAICS code 541711, reserved exclusively for small business concerns, and is managed by the USDA Agricultural Research Service through its Albany Facility. The opportunity was posted on August 4, 2026, with a firm response deadline of August 28, 2026, and the performance location is specified as Ithaca, New York, with a zip code of 14853. The contract type and set-aside status emphasize support for small business participation in federally funded scientific research aimed at improving agricultural outcomes.

USDA Ars Afm Apd

POSTED

DEADLINE

Aphid cDNA Prey Library DevelopmentThe contract involves the development of a normalized cDNA library from aphid RNA supplied by the government, specifically for use in yeast two-hybrid prey systems. The work includes reverse transcription of the RNA into complementary DNA and subsequent cloning procedures to generate a high-quality, representative library that enables effective protein-protein interaction screening. The project is designed to support biological research efforts by providing a standardized, scalable prey library that enhances the reliability and depth of interaction data in functional genomics studies. This subcontract is designated as a Small Business Set Aside under the NAICS code 541711, indicating it is reserved for small businesses engaged in research and development in the life sciences. The work is to be performed in Ithaca, New York, with a response deadline of August 28, 2026, and was posted on August 4, 2026. The contracting entity is the USDA Agricultural Research Service, Agricultural Facilities Management and Application Personnel Division, and the project is intended to advance USDA’s mission in agricultural biotechnology and pest research through innovative molecular tools.

USDA Ars Afm Apd

POSTED

DEADLINE

Viral Bait Clone ConstructionThe contract involves the design and molecular cloning of viral protein bait constructs specifically for use in yeast two-hybrid systems, requiring comprehensive molecular biology expertise including codon optimization for host compatibility, precise plasmid insertion, and rigorous sequence validation to ensure accuracy and functionality. The work focuses on creating reliable protein baits that enable the study of virus-host protein interactions, which is critical for understanding pathogenic mechanisms and identifying potential therapeutic targets. All constructs must meet high standards of precision to support downstream functional assays in a controlled laboratory environment. The contract is designated as a Small Business Set Aside under NAICS code 541711 for scientific research and development, with performance to be carried out in Ithaca, New York, at the USDA ARS AFM APD facility. It was posted on August 4, 2026, and responses are due by August 28, 2026, with a clear emphasis on delivering technically robust and validated molecular reagents within the specified timeframe. The scope demands a high level of technical proficiency in molecular cloning, sequence analysis, and bioinformatics tools, with deliverables expected to support ongoing virology and host-pathogen interaction research funded by the U.S. Department of Agriculture.

USDA Ars Afm Apd

POSTED

DEADLINE

In Vitro ADMET AssaysThe contract titled In Vitro ADMET Assays calls for the performance of high-throughput in vitro screening focused on metabolic stability, hepatotoxicity, CYP450 enzyme interactions, and cellular permeability to support early-stage drug development. These assays are critical for evaluating the absorption, distribution, metabolism, excretion, and toxicity profiles of potential therapeutic candidates, enabling informed decisions before advancing compounds into costly clinical stages. The work will be conducted to meet the specific needs of the National Institutes of Health NIDA under the Department of Health and Human Services, with performance expected to occur in Bethesda. This is a subcontract opportunity under NAICS code 541711, which classifies it as research and development in the physical, engineering, and life sciences. The solicitation was posted on August 3, 2026, with a response deadline of August 18, 2026, at 7:00 PM Eastern Time. There is no set-aside classification specified, and no point of contact or detailed office address is provided in the data. Interested parties must submit their proposals before the deadline to be considered for award, with the expectation that the selected contractor will deliver reliable, scalable, and scientifically rigorous ADMET data to guide NIDA’s research initiatives in drug development.

National Institutes Of Health Nida

POSTED

DEADLINE

in about 17 hours

Genotoxicity and Carcinogenicity TestingThe contract seeks to perform in vitro and in vivo assays to assess the mutagenic and carcinogenic risks of drug candidates, ensuring compliance with regulatory safety standards for pharmaceutical development. The work is critical for identifying potential genetic toxicity and cancer-causing properties early in the drug evaluation process to support regulatory submissions and public health safeguards. The solicitation is issued as a subcontract under the National Institutes of Health NIDA, part of the Department of Health and Human Services, with performance expected to take place in Bethesda. It falls under the NAICS code 541711 for research and development in the physical, engineering, and life sciences. The proposal must be submitted by August 18, 2026, with the opportunity posted on August 3, 2026. No set-aside provisions are specified, and the contract is open to qualified subcontractors with the technical capacity to deliver high-quality genotoxicity and carcinogenicity testing services.

National Institutes Of Health Nida

POSTED

DEADLINE

in about 17 hours

Safety Pharmacology (CNS, Cardiovascular, Pulmonary)The contract requires comprehensive safety pharmacology studies to evaluate adverse effects on the central nervous system, cardiovascular system, and pulmonary function, ensuring alignment with ICH safety guidelines. The work will involve detailed pharmacodynamic assessments to identify and characterize potential risks to major organ systems during early drug development, with a focus on identifying safety signals that could impact clinical translation. This subcontract, issued by the National Institutes of Health’s NIDA under the Department of Health and Human Services, is set to be performed in Bethesda and has a response deadline of August 18, 2026. The effort is classified under NAICS code 541711, indicating it pertains to research and development in the life sciences, and is aimed at supporting regulatory-compliant preclinical safety evaluations essential for pharmaceutical advancement.

National Institutes Of Health Nida

POSTED

DEADLINE

in about 17 hours

More opportunities from Department Of Health And Human Services → National Institutes Of Health Olao

Same awarding agency

Unlimited Telephone Technical SupportThe Unlimited Telephone Technical Support subcontract, issued by the National Institutes of Health Olao under the Department of Health and Human Services, focuses on providing comprehensive remote technical assistance. The scope of work includes unlimited support for system operation, troubleshooting, and user guidance, all delivered during standard business hours. This opportunity is categorized under NAICS code 541519. It was posted on August 17, 2026, with a response deadline of August 21, 2026.

Other Computer Related Services

POSTED

about 14 hours ago

DEADLINE

Emergency On-Site Repair ServicesThe Emergency On-Site Repair Services subcontract, issued by the National Institutes of Health Olao under the Department of Health and Human Services, requires the provision of emergency on-site repair support. The primary objective is to ensure system stability through a guaranteed 48-hour response time for any system failure, with mandatory availability during weekends and holidays. This opportunity is categorized under NAICS code 811212 and was posted on August 17, 2026. Interested parties must submit their responses by the deadline of August 21, 2026, at 6:00 PM.

Computer and Office Machine Repair and Maintenance

POSTED

about 14 hours ago

DEADLINE

Software Revisions and Updates for Flow CytometersThis subcontract opportunity, issued by the National Institutes of Health Olao under the Department of Health and Human Services, requires the performance of software revisions and updates for four flow cytometry systems. The primary objective is to ensure all systems are compliant with the latest manufacturer specifications and maintain operational stability. The project falls under NAICS code 541512 for computer systems design services. Interested parties must submit their responses by August 21, 2026, following the posting date of August 17, 2026.

Computer Systems Design Services

POSTED

about 14 hours ago

DEADLINE

Flow Cytometer Preventative Maintenance Kits SupplyThis subcontract opportunity, issued by the National Institutes of Health Olao under the Department of Health and Human Services, seeks the supply of preventative maintenance kits for cytometry systems. The requirement specifies the delivery of two kits for each of the four systems, totaling eight kits, which will be utilized during annual inspections. The procurement is categorized under NAICS code 423490. Interested parties must submit their responses by the deadline of August 21, 2026, following the posting date of August 17, 2026.

Other Professional Equipment and Supplies Merchant Wholesalers

POSTED

about 14 hours ago

DEADLINE

Flow Cytometer Preventative Maintenance ServicesThe National Institutes of Health Olao, under the Department of Health and Human Services, is seeking a subcontract for Flow Cytometer Preventative Maintenance Services. The scope of work requires two annual preventative maintenance inspections for four flow cytometry systems, which must include on-site diagnostics, calibration, cleaning, and performance verification. This opportunity is categorized under NAICS code 811212. The solicitation was posted on August 17, 2026, and the deadline for responses is August 21, 2026.

Computer and Office Machine Repair and Maintenance

POSTED

about 14 hours ago

DEADLINE

Specialized Bioinformatics & Genomic Data Analysis for iPSC EditsThis subcontract opportunity with the National Institutes of Health Olao under the Department of Health and Human Services focuses on specialized bioinformatics and genomic data analysis for iPSC edits. The primary objective is to analyze NGS, Sanger, and PacBio sequencing data to validate genome edits, confirm clonality, and ensure the genetic integrity of iPSC lines in accordance with iNDI standards. The project is based in Bethesda, Maryland, and falls under NAICS code 541690. Interested parties must respond by the deadline of August 21, 2026, following the posting date of August 17, 2026.

Other Scientific and Technical Consulting Services

POSTED

about 14 hours ago

DEADLINE

Repository-Ready iPSC Line Preparation & DeliveryThis subcontract, titled Repository-Ready iPSC Line Preparation and Delivery, is issued by the National Institutes of Health OLAO under the Department of Health and Human Services. The primary objective is the preparation of engineered iPSC lines for deposit into the NIH iNDI repository. This process encompasses cryopreservation, the creation of necessary documentation, metadata standardization, and the secure cold-chain delivery of materials to Bethesda, Maryland. The opportunity was posted on August 17, 2026, with a response deadline of August 21, 2026. The work is categorized under NAICS code 488999, and the place of performance is designated as Bethesda, zip code 20892.

All Other Support Activities for Transportation

POSTED

about 14 hours ago

DEADLINE

Comprehensive iPSC Quality Control & Validation ServicesThis subcontract, issued by the National Institutes of Health Olao under the Department of Health and Human Services, seeks a provider to perform comprehensive quality control and validation services for iPSC lines. The scope of work includes critical technical assessments such as sequencing, mycoplasma testing, SNP array, and karyotyping, as well as the use of long-read PacBio confirmation to verify edits. The opportunity was posted on August 17, 2026, with a response deadline of August 21, 2026. The performance of these services is designated for Bethesda, and the contract falls under NAICS code 541380.

Testing Laboratories and Services

POSTED

about 14 hours ago

DEADLINE

Validation and Optimization of ONE-STEP Tagging in Human induced Pluripotent Stem Cells

Solicitation # NIH-NOI-PCA-NIA-01590

The National Institute on Aging (NIA), under the National Institutes of Health (NIH) and Department of Health and Human Services (HHS), has issued a Notice of Intent to Sole Source for the validation and optimization of ONE-STEP tagging in human induced pluripotent stem cells (iPSCs). This acquisition aims to support the iPSC Neurodegenerative Disease Initiative (iNDI) and the Center of Alzheimer’s Disease and Related Dementias (CARD) by generating functionally engineered iPSC lines for research into Alzheimer’s disease and related dementias. The project involves high-activity guide identification, Bxb1 mRNA and cargo plasmid delivery optimization, and the generation of ADRD variant, MAPT 4R, and wild-type process-control clones. All deliverables must be repository-ready, meeting strict quality control standards including long-read sequencing, karyotype analysis, and SNP arrays to ensure scientific continuity and data integrity. The government intends to award this contract to The Jackson Laboratory, citing them as the only responsible source capable of meeting the requirements under FAR 6.302-1 and FAR 13.501(a). This determination is based on the laboratory's unique continuity with the existing iNDI program, established workflows for specific background lines, and proven success in large-scale CRISPR/Cas9 engineering. The total estimated contract value is 3,353,115.00 dollars, covering a base year from September 1, 2026, to August 31, 2027, and an option year extending to August 31, 2028. While this is a sole-source intent, the government will consider capability statements from other sources submitted by August 21, 2026, to determine if adequate competition exists.

Research and Development in Biotechnology (except Nanobiotechnology)

POSTED

about 14 hours ago

DEADLINE

Non-competitive Combines Synopsis Solicitation- Se

Solicitation # 75N98026Q01020

The National Institutes of Health Office of the Director intends to award a non-competitive, firm fixed-price contract to USBDB Service Contract Admin for the maintenance of four flow cytometry systems, specifically two A5 SE Standard Cytometers and two S6 Cell Sorters, located at the Vaccine Research Center in Bethesda, Maryland. Conducted under FAR 12.603 and FAR 6.302-3(a)(2)(ii), this acquisition is for commercial services and is not expected to exceed the simplified acquisition threshold. The period of performance is scheduled from September 1, 2026, through August 31, 2027. The scope of work includes comprehensive service coverage consisting of two preventative maintenance inspections and two maintenance kits annually, software revisions, unlimited weekday service visits, and unlimited telephone support. A critical requirement is a 48-hour guaranteed emergency on-site response, with a 500 dollar credit applied if the deadline is missed. Workstation printers are explicitly excluded from coverage. Inspection and acceptance will be performed by the government at the destination in Bethesda, Maryland, ensuring all services meet industry and manufacturer standards. Proposals are due by August 21, 2026, and must include a Unique Entity Identifier, Taxpayer Identification Number, and active SAM registration.

Electronic and Precision Equipment Repair and Maintenance

POSTED

about 14 hours ago

DEADLINE

Basic Operator Training for Ultracentrifuge SystemsThis subcontract, titled Basic Operator Training for Ultracentrifuge Systems, is issued by the National Institutes of Health Olao under the Department of Health and Human Services. The primary objective is to provide introductory training for lab personnel focusing on the safe operation, rotor usage, programmable profiles, and general maintenance of a new ultracentrifuge system. The performance of these services will take place in Bethesda, Maryland. The solicitation was posted on August 16, 2026, with a response deadline of August 25, 2026. The contract is categorized under NAICS code 611430.

Professional and Management Development Training

POSTED

DEADLINE

Laboratory Equipment Trade-In and Decommissioning ServicesThis subcontract, issued by the National Institutes of Health Olao under the Department of Health and Human Services, involves the decommissioning and removal of a Beckman Optima XL-100K ultracentrifuge. The scope of work includes the responsible disposal or trade-in of the equipment, comprehensive site cleanup, and the provision of detailed chain-of-custody documentation. The project will be performed in Bethesda, Maryland, under NAICS code 562920. Interested parties must submit their responses by the deadline of August 25, 2026, at 13:00.

Materials Recovery Facilities

POSTED

DEADLINE