This Government Contract opportunity from Department Of Health And Human Services was posted on August 17, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Validation and Optimization of ONE-STEP Tagging in Human induced Pluripotent Stem Cells

Closed

NIH-NOI-PCA-NIA-01590Federal

Submission Closed08/21/2026, 03:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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AI Contract Overview

The National Institute on Aging (NIA), under the National Institutes of Health (NIH) and Department of Health and Human Services (HHS), has issued a Notice of Intent to Sole Source for the validation and optimization of ONE-STEP tagging in human induced pluripotent stem cells (iPSCs). This acquisition aims to support the iPSC Neurodegenerative Disease Initiative (iNDI) and the Center of Alzheimer’s Disease and Related Dementias (CARD) by generating functionally engineered iPSC lines for research into Alzheimer’s disease and related dementias. The project involves high-activity guide identification, Bxb1 mRNA and cargo plasmid delivery optimization, and the generation of ADRD variant, MAPT 4R, and wild-type process-control clones. All deliverables must be repository-ready, meeting strict quality control standards including long-read sequencing, karyotype analysis, and SNP arrays to ensure scientific continuity and data integrity. The government intends to award this contract to The Jackson Laboratory, citing them as the only responsible source capable of meeting the requirements under FAR 6.302-1 and FAR 13.501(a). This determination is based on the laboratory's unique continuity with the existing iNDI program, established workflows for specific background lines, and proven success in large-scale CRISPR/Cas9 engineering. The total estimated contract value is 3,353,115.00 dollars, covering a base year from September 1, 2026, to August 31, 2027, and an option year extending to August 31, 2028. While this is a sole-source intent, the government will consider capability statements from other sources submitted by August 21, 2026, to determine if adequate competition exists.

General Info

NIA sole source contract to Jackson Laboratory for iPSC tagging and cellular modeling.

Agency

Department Of Health And Human Services → National Institutes Of Health Olao

Contract Value

$1,673,413

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Bethesda, MD, 20892, USA

Set-Aside

NONE

Awardee

JACKSON LABORATORY

Award Issued Date

09/01/2026, 12:00:00 AM UTC

Documents

JOFOC for Validation and Optimization of ONE-STEP Tagging in Human iPSCs

justification-and-authorization

High

Notice of Intent to Sole Source PCA-NIA-01590

special-notice

Low

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseClosed

PostedAug 17

special-notice

Response DeadlineAug 21

Deadline has passed

Submission Closed

08/21/2026, 03:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

Contacts2 people available

OfficeBETHESDA, MD, 20892, USA

Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

Office AddressBETHESDA, MD, 20892, USA

Contacts

Linda Smith

contact@example.gov

Danielle Tines

contact@example.gov

Full Description

NOTICE OF INTENT TO SOLE SOURCE
Notice ID: PCA-NIA-01590

Department/Ind. Agency: Department of Health and Human Services (HHS)
Sub-tier: National Institutes of Health (NIH)
Office: National Institute on Aging (NIA)

Notice Type: Special Notice / Notice of Intent to Sole Source
Posted Date: August 17, 2026
Response Date: August 21, 2026, 11:00 AM EST
NAICS Code: 541714 – Research and Development in Biotechnology (except Nanobiotechnology)
PSC Code: B529 – Special Studies/Analysis – Scientific Data

Description

This is a Notice of Intent to Sole Source and is issued for informational purposes only.

The National Institute on Aging (NIA), National Institutes of Health (NIH), Department of Health and Human Services (HHS), intends to negotiate and award a sole source contract to:

The Jackson Laboratory
600 Main Street
Bar Harbor, ME 04609-1500
UEI: XR6LMXNKDJJ1

for the acquisition titled:

Validation and Optimization of ONE-STEP Tagging in Human induced Pluripotent Stem Cells

The Government anticipates awarding this requirement under the authority of FAR 13.501(a) and FAR 6.302-1, Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements.

This Is Not a Request for Quotes

This notice is not a Request for Quotations (RFQ), Request for Proposals (RFP), or Invitation for Bids (IFB). The Government does not intend to solicit competitive quotes or proposals in response to this notice. No solicitation package is available.

This notice shall not be construed as a commitment by the Government to issue a solicitation, award a contract, or pay for any information submitted in response to this notice.

However, any responsible source that believes it is capable of satisfying the Government’s requirement may submit a capability statement for consideration. Capability statements must be submitted by the response deadline identified in this notice. The Government will review all timely responses solely for the purpose of determining whether adequate competition exists to support a competitive procurement.

Background

The National Institute on Aging requires highly specialized human induced pluripotent stem cell (iPSC) engineering services to support the iPSC Neurodegenerative Disease Initiative (iNDI) and the Center of Alzheimer’s Disease and Related Dementias (CARD). The purpose of this acquisition is to validate and optimize the ONE-STEP tagging system and generate functionally engineered iPSC lines for Alzheimer’s disease and related dementias (ADRD) research.

This work is part of an ongoing NIA/CARD effort to create rigorously characterized, genetically defined cellular models and distribute them to the research community as standardized resources. The requirement builds upon prior iNDI engineering efforts and requires continuity of methods, quality control, and repository-compatible deliverables.

Required Services

The contractor shall provide all personnel, materials, equipment, facilities, and technical expertise necessary to perform the required work, including but not limited to:

identification of high-activity guides for monoallelic and biallelic attP insertion at safe harbor loci;
optimization of Bxb1 mRNA and cargo plasmid delivery;
testing of novel landing pad designs and alternative reagents;
validation of monoallelic and biallelic ONE-STEP tagging across multiple loci;
validation of cargo design for ONE-STEP tagging;
generation of functionalized iPSC lines, including ADRD variant lines, MAPT 4R lines, wild-type process-control clones, and Discovery background CRISPR machinery lines;
advanced quality control and sequencing validation; and
repository-ready delivery of engineered cell lines.

Sole Source Rationale

The Jackson Laboratory is the only known source capable of meeting the Government’s requirement due to its unique combination of:

direct continuity with the existing iNDI engineering program;
demonstrated success in large-scale CRISPR/Cas9 engineering of human iPSCs;
established workflows for KOLF2.1J, FA13.1J, and Discovery background lines;
validated quality control pipelines, including long-read sequencing and repository deposition; and
prior successful performance on related NIA iNDI and iNDI+ efforts.

Award to another source would result in unacceptable duplication of cost, schedule delay, and scientific risk due to the need to re-establish workflows and demonstrate comparability with the existing iNDI collection.

Period of Performance

Base Year: September 1, 2026 – August 31, 2027
Option Year 1: September 1, 2027 – August 31, 2028

Submission Instructions

Interested organizations may submit a capability statement demonstrating their ability to satisfy the Government’s requirement. Capability statements must clearly address the organization’s ability to provide:

specialized iPSC engineering services at the required scale;
validated workflows compatible with the existing iNDI program;
experience with KOLF2.1J, FA13.1J, and related Discovery background lines;
advanced sequencing-based quality control and validation; and
repository-ready delivery of engineered cell lines.

Capability statements shall be limited to a reasonable length and must include sufficient technical detail to allow the Government to evaluate the respondent’s capability.

Responses must be received no later than:

August 21, 2026, 11:00 AM EST

Responses shall be submitted via email to both of the points of contact listed below.

Primary Point of Contact

Linda Smith
Email: linda.smith2@nih.gov

Secondary Point of Contact

Danielle Tines
Email: danielle.tines@nih.gov

Contracting Office Address

Office of Acquisitions
National Institutes of Health
Department of Health and Human Services
Bethesda, MD 20892