This Government Contract opportunity from Department Of Veterans Affairs was posted on August 14, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.
Q301--Zymo Epigenome Sequencing Services
Contract Overview
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The Department of Veterans Affairs, specifically the VA Bedford Healthcare System, intends to award a sole source, firm-fixed-price contract to Zymo Research Corporation for Reduced Representation Bisulfite Sequencing services. This project involves DNA methylation profiling of 269 post-mortem human choroid plexus tissue samples, encompassing sample handling, quality control, bisulfite conversion, library preparation, sequencing, and data alignment. The scope of work includes generating approximately 30 million read pairs per sample and producing genome browser tracks. This procurement is conducted as a sole source under authority RFO 6.103-1 because Zymo Research Corporation previously generated a prefrontal cortex dataset for the same study. Utilizing the same vendor is critical to avoid technical confounds that would compromise the scientific validity of the cross-tissue comparison. The requirement falls under NAICS code 541714 and PSC Q301. Interested parties must submit responses by August 21, 2026, at 11:00am EST.
General Info
Contract Value
$81,075Place of Performance
ME, USASet-Aside
Awardee
ZYMO RESEARCH CORPORATIONAward Issued Date
Timeline
Submission Closed
Organization & Contact Information
Full Description
This is not a solicitation. The Department of Veterans Affairs, VA Bedford Healthcare System intends to award a sole source, firm-fixed-price contract to Zymo Research Corporation for Reduced Representation Bisulfite Sequencing (RRBS) services for DNA methylation profiling of 269 post-mortem human choroid plexus tissue samples. Description of Supplies/Services: RRBS services on 269 post-mortem human choroid plexus tissue samples, including sample handling and QC assessment, bisulfite conversion, library preparation and QC assessment, sequencing (~30 million read pairs per sample), and raw data alignment, methylation calling, and genome browser track generation. This requirement supports an ongoing VA research study requiring DNA methylation data from choroid plexus tissue that is directly comparable, at the laboratory-batch level, to an existing dorsolateral prefrontal cortex methylation dataset previously generated in its entirety by Zymo Research Corporation for the same study. Introducing a second laboratory to generate the choroid plexus data would create a vendor-of-origin technical confound that is inseparable from the biological comparison the study is designed to detect, and this confound cannot be reliably resolved through statistical correction after the fact. Zymo Research Corporation is the only vendor that can generate this data using the same laboratory, personnel, and protocol as the existing dataset, thereby preserving the scientific validity of the planned cross-tissue comparison. The contractor will provide the required services. Since the intent is to procure this on a sole source basis, no solicitation will be posted to Contracting Opportunities SAM.gov. A Sources Sought Notice (36C241-26-AP-4037) was previously posted for this requirement; responses received did not identify a source able to meet this specific requirement without introducing the technical confound described above. The authority for this action is RFO 6.103-1, Only One Responsible Source and No Other Supplies or Services Will Satisfy the Agency's Requirements. The NAICS code is 541714. The size standard is 1,000 employees. The PSC is Q301. Interested persons may contact the Contract Specialist by email at [email] regarding this procurement. The determination to conduct a competitive procurement based on responses to this notice is solely within the discretion of the Contracting Officer. Response must be received by 8/21/26 NLT 11:00am EST.
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