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Genome Editing Construct and Delivery System Optimization

Active

Grant

Response Deadline10/10/2028, 04:00:00 AM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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This subcontract focuses on the design and optimization of genome editing constructs and biologic delivery systems to support prime contractors on NIH/NINDS genomic therapy projects. The scope of work involves utilizing CRISPR/Cas technology along with viral and non-viral vectors to refine editing constructs and delivery mechanisms. The selected provider will be responsible for assessing critical metrics including bioactivity, target engagement, durability, pharmacokinetics, and bioavailability. The final deliverables for this engagement consist of optimized therapeutic leads accompanied by comprehensive bioactivity and pharmacokinetics data reports.

General Info

Subcontract for designing genome editing constructs and delivery systems for NIH genomic therapy projects.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

This scope was carved out of RFA-NS-28-012.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)

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Timeline

PostedNov 3

subcontract

Response DeadlineOct 10

Submission deadline

Response Deadline

10/10/2028, 04:00:00 AM UTCin almost 2 years

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health

ContactsNo contacts available

OfficeN/A

Organization / Agency

Department Of Health And Human Services → National Institutes Of Health

Office AddressN/A

ContactsNo contact information available

Full Description

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Performs the design and optimization of genome editing constructs and biologic delivery systems for prime contractors on NIH/NINDS genomic therapy projects. Optimizes editing constructs and delivery systems using CRISPR/Cas or viral/non-viral vectors. Assesses bioactivity, target engagement, durability, pharmacokinetics, and bioavailability. Delivers optimized therapeutic leads and supporting bioactivity/PK data reports.

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