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This Solicitation opportunity from Government of Canada was posted on November 25, 2025. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

High throughput device for rapid cellular metabolic characterization

Closed
25-58185International

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The National Research Council of Canada is seeking a high-throughput instrument for rapid cellular metabolic characterization to support its cell culture scale-up team. The device will be used to screen phenotypes and metabolic requirements of cell lines used in large-scale bioreactors for the production of vaccines, viral vectors, and recombinant proteins. Key technical requirements include the ability to measure multiple metabolites in parallel within live cells at temperatures between 32oC and 37oC, with a specific focus on mitochondrial activity, respiration, and the evaluation of compounds to enhance cell growth and productivity. This federal solicitation, numbered 25-58185, requires all deliverables to be received within two months of the contract award date. Interested parties can coordinate with the primary point of contact, Veronica Exari, regarding this procurement for the Government of Canada.

General Info

NRC seeks high-throughput metabolic characterization instrument for cell culture scale-up within two months.

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Organization & Contact Information

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AgencyGovernment of Canada → National Research Council of Canada
Contacts1 person available
OfficeN/A

Full Description

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Description: OBJECTIVE: The cell culture scale-up team (CCSU) has a requirement for an instrument for rapid cellular metabolic characterization. The instrument will be used to characterize and screen the phenotype and the metabolic requirements of cell lines developed at the NRC and used in large-scale bioreactors. BACKGROUND: Cell lines can be used to produce monoclonal antibodies, recombinant proteins, viral vectors, vaccines, viruses and virus-like-particles. In large-scale bioreactor, the metabolic profile of a cell line has a critical impact on its productivity. The presence of certain nutrients in the cell culture media is also a strong determinant of the cell line performance. Therefore, we are looking for an instrument that will enable measurements of multiple metabolites in parallel at 32oC to 37oC in live cells. We are particularly interested in measurements of metabolites involved in mitochondrial activity and respiration. We also need to screen different compounds that might improve cell growth and productivity in a high-throughput fashion. All the deliverables must be received within 2 months after the contract award date.

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