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Limited Competition: Small Grant Program for NHLBI K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)

Active

RFA-HL-27-004Grant

Response Deadline11/07/2028, 05:00:00 AM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

Notice of Funding Opportunity RFA-HL-27-004 is a limited competition solicitation from the National Institutes of Health and the National Heart, Lung, and Blood Institute designed to facilitate the transition to research independence for current or recently completed NHLBI K01, K08, K23, and K25 awardees. The program provides R03 small grant support for projects that can be completed within two years, with direct costs limited to 85,000 dollars per year. Eligible projects include pilot or feasibility studies, proof of concept studies, secondary analysis of existing data, and the development of new research methodologies or technologies. The primary objective is to generate critical preliminary data to support a subsequent R01-equivalent independent grant application. Applicants must maintain a minimum of 40 percent protected research effort and provide a detailed plan and timeline for submitting future R01 applications. Required documentation includes a summary of K award research progress, an institutional commitment letter, and a data management and sharing plan. Applications are evaluated based on significance, innovation, approach, investigator expertise, and the environment, with a specific focus on how the proposed work evolved from the previous K award. The funding opportunity remains open through November 8, 2028, with the NHLBI intending to commit total funding across fiscal years 2027 through 2030. All awards are subject to federal regulations 42 CFR Part 52 and 2 CFR Part 200, and recipients must adhere to strict cybersecurity incident reporting and clinical trial training requirements.

General Info

NHLBI R03 grants for K awardees to generate preliminary data for R01 applications.

Agency

Department Of Health And Human Services → National Institutes Of Health

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

RFA-HL-27-004 Revised Full Announcement

28 pages · presolicitation

High

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseSolicitation

PostedMay 12

Solicitation

Response DeadlineNov 7

Submission deadline

Response Deadline

11/07/2028, 05:00:00 AM UTCin about 2 years

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health

Contacts1 person available

OfficeUSA

Organization / Agency

Department Of Health And Human Services → National Institutes Of Health

Office AddressUSA

Contacts

National Institutes of Health

contact@example.gov

+1 (555) 000-0000

Full Description

This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that invites applications from eligible organizations to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered. The purpose of this NOFO is to solicit current or recently completed NHLBI K01, K08, K23, and K25 awardees for small grant support to expand their current research objectives or to branch out to a new study emerging from their K award research. This NOFO is intended to facilitate the transition to research independence for these NHLBI K awardees. Current NHLBI K01, K08, K23, and K25 awardees may apply for this R03 support starting in the third year of their K award Project Period. Recently completed NHLBI K01, K08, K23, and K25 award recipients are eligible to apply or resubmit A1 applications if the earliest potential R03 award start date is within two years of the end of their K award Project Period.The R03 grant mechanism supports research projects that can be completed within two years and with limited resources. These projects are expected to generate preliminary data to bolster a subsequent R01-equivalent application. Eligible projects include, but are not limited to, pilot or feasibility studies; proof of concept studies; secondary analysis of existing data; small, self-contained research projects; development of new research methodologies or technologies, or creation of novel experimental model systems.Applicants are required to maintain a minimum of 40% protected research effort during the R03 award period. This requirement can be fulfilled through a combination of effort on the proposed R03 project and other research projects, irrespective of funding source.For current and former K23 awardees, the research proposed in the R03 application may or may not include patient-oriented research.