Miniaturized Two-Photon Microscope System Design & Integration

The contract requires the full design, engineering, and integration of a miniaturized head-mounted two-photon microscope system tailored for in vivo neural imaging in freely moving animals. This involves the seamless fusion of optical, mechanical, and electronic components into a turn-key solution capable of delivering high-resolution imaging during natural animal behavior. The system must be lightweight, robust, and engineered for long-duration use without compromising signal quality or animal mobility, with all subsystems coordinated to function as a unified, field-ready instrument. The project is issued as a subcontract under the NAICS code 334516 for medical equipment and supplies manufacturing, sponsored by the National Institutes of Health through the Department of Health and Human Services. The proposal deadline is July 7, 2026, and while no set-aside or location details are specified, the successful bidder must demonstrate expertise in neuroimaging hardware, wearable micro-optics, and real-time data acquisition systems. The final deliverable must be a fully functional, self-contained system ready for immediate deployment in preclinical research environments, with no additional assembly or customization required by the end user.