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This Solicitation opportunity from Department Of Health And Human Services was posted on March 13, 2023. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

National Cancer Institute (NCI) Small Business Innovation Research (SBIR) Innovative Concept Award Program - Fiscal Year 2024

Closed
75N91023R00034Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 54171
New
Federal
System Vicarious Calibration (SVC) of the NASA Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) Ocean Color Instrument (OCI) Using HyperNAV
Solicitation # NASA-SVC-PACE-OCI
NASA Headquarters is seeking a firm-fixed-price contract for the sustained operation and maintenance of eight HyperNav hyperspectral radiometric systems. This effort supports the System Vicarious Calibration of the NASA Plankton, Aerosol, Cloud, ocean Ecosystem PACE Ocean Color Instrument. The scope includes conducting eight rotational 60-day deployments annually across sites in Hawaii, Puerto Rico, and Mo'orea, French Polynesia, maintaining the float fleet, and delivering daily SVC-qualified radiometric products to the NASA PACE Ocean Ecology Lab. The contractor is required to deliver a minimum of 160 quality-assured in-situ SVC observations over the period of performance. NASA intends to award this as a sole source contract to Oregon State University, citing their unique specialized knowledge and role as the developer of the HyperNav system. Performance will take place at the contractor's facility and at the deployment sites. Key deliverables include daily SVC measurements, annual progress reports, and a final scientific and technical report. Payment is structured around milestones, with 30 percent of the total price allocated to monthly operations and data delivery. The contract requires adherence to NIST SP 800-161 for IT security and compliance with the Federal Records Act and NASA's Open Science and Data Management Plan.
NASA Headquarters

POSTED

5 days ago

DEADLINE

in 13 days
NAICS: 54171
New
Federal
Pipeline Safety Research and Development (R&D) - Research Announcement 12
Solicitation # 693JK326RA001
The Department of Transportation's Pipeline and Hazardous Materials Safety Administration (PHMSA) is soliciting applications for pipeline safety research projects under Research Announcement 12 (693JK326RA001). These projects will be funded through Other Transaction Agreements (OTAs) on a fixed-price basis. The research focuses on five priority areas: Anomaly and Threat Detection, Liquid Leak Detection, Liquefied Natural Gas (LNG), Repair and Rehabilitation, and Threat Prevention. A primary goal is to transition technologies from Technology Readiness Level (TRL) 5 to TRL 6 or 7 through operational testing and validated performance results. Applicants must be registered in the System for Award Management (SAM) and PHMSA's R&D Management Information System (MIS). Proposals are limited to 20 pages and are evaluated by a Merit Review Panel based on criteria including technical approach, team expertise, cost appropriateness, and technology transfer plans. A mandatory cost-share is required, with a minimum of 50 percent for technology development and 20 percent for knowledge development. Additionally, all awarded projects must establish a Technical Advisory Panel (TAP) including at least two academic representatives to review final reports. Full proposal packages must include Appendices A and B, along with six specific attachments, including a budget summary and a technical milestone schedule. All documents must be submitted in PDF format, except for the milestone schedule, which requires an editable Excel file. The deadline for electronic submission via the MIS portal is 5:00 p.m. EST on November 2, 2026. Payments are tied to the completion of project items as verified by a Technical Manager and Agreement Administrator.
693JK3 Acquisition Services Division

POSTED

6 days ago

DEADLINE

in 13 days
NAICS: 54171
Federal
2026 Distributed Wind Turbine Competitiveness Improvement Project
Solicitation # RFX-2026-10008
The 2026 Distributed Wind Turbine Competitiveness Improvement Project (CIP), solicitation RFX-2026-10008, is a best-value selection effort managed by the National Laboratory of the Rockies (NLR) for the Department of Energy. The project aims to enhance U.S. leadership in distributed energy by assisting domestic manufacturers in reducing the Levelized Cost of Energy (LCOE) for wind turbines with a rated power of 1000 kW or smaller. The scope is divided into thirteen topic areas across three primary categories: wind turbine development, power electronics development, and common areas such as manufacturing process innovation, technology commercialization, and field validation. The project emphasizes increasing the number of certified turbines in the U.S. market and requires adherence to professional engineering standards, including ANSI/ACP 101-1-2021 for small turbines and UL electrical safety standards. Subcontracts will be awarded as Firm Fixed Price with Price Participation, with maximum award amounts ranging from 200,000 to 800,000 dollars depending on the topic area. The standard period of performance is twenty-one months, though field validation projects may extend up to sixty months. Evaluation is based on a combination of technical factors, team qualifications, and listing plans, with additional programmatic weight given to manufacturer, geographic, system configuration, topic, and turbine size diversity to ensure a balanced cohort of small American businesses. Eligible offerors must be U.S. companies performing work within the United States. Key administrative requirements include electronic invoicing via the NLR Accounts Payable office and strict adherence to DOE public affairs and classified information directives.
Llc - DOE Contractor Alliance For Energy Innovation

POSTED

21 days ago

DEADLINE

in 24 days
NAICS: 54171
Federal
Chain Reaction Innovations - Energy Technology Innovation
Solicitation # 6-BB47-P-00203-00
The Chain Reaction Innovations program, managed by Argonne National Laboratory for the Department of Energy, is seeking innovators for its 2027 cohort to accelerate the commercialization of early-stage physical science and energy technology. This initiative embeds selected innovators within the laboratory for up to 24 months, providing access to specialized facilities, technical mentorship, and funding. Support is structured through a first-year ORISE fellowship, which includes a personal stipend, travel allowance, and health benefits, with the possibility of a second-year renewal based on a midpoint performance review. All participants must enter into a standard, non-negotiable Cooperative Research and Development Agreement (CRADA) and obtain DOE approval for site access. Eligibility is limited to individuals who are U.S. citizens or lawful permanent residents with at least five years of research and development experience; incorporated entities are prohibited from applying. Applicants are evaluated on their technical strength, entrepreneurial drive, the potential economic impact of their project concept, and the alignment of their technology with the DOE mission. Required application materials include a personal narrative, a technical vision, a business idea, a one-page resume, and a five-page technical deck, all submitted via the program's online portal. The program emphasizes high-impact innovations that enhance national, economic, and energy security.
Argonne National Labor - DOE Contractor

POSTED

about 1 month ago

DEADLINE

in 10 days
NAICS: 54171
Federal
N0016425SC001 CSO
Solicitation # N0016425SC001
The Naval Surface Warfare Center, Crane Division (NSWC Crane) is utilizing a Commercial Solutions Opening (CSO) under solicitation N0016425SC001 to rapidly acquire innovative commercial products and services. The objective is to identify and integrate advanced technologies across three primary mission areas: Expeditionary Warfare, Strategic Missions, and Electromagnetic Warfare. This competitive, three-phased process consists of an initial Solution Brief, a Pitch session, and a final written proposal. Awards are issued on a fixed-price basis and may take the form of FAR-based contracts, Purchase Orders, Bailment Agreements, or prototype Other Transaction (OT) agreements. Specific Areas of Interest (AOIs) have been released for various high-priority projects, including the Miniature Aiming System (MAS) Machine Gun Optic, the Small Modular Optic and Laser Designator (SMOLDr), the Hypervelocity Improved Capability Assault Rifle (HICAR), the Modular Kinetic Lethal Drone (MKLD), and the Flyweight Assault Machine Gun (FAMG). These projects focus on enhancing lethality and readiness through advancements in electro-optic systems, man-portable belt-fed weapons, and autonomous loitering munitions. Successful completion of a prototype OT project, validated through milestones such as User Evaluation and Operational Testing, may lead to a follow-on production contract without further competition.
Nswc Crane

POSTED

4 months ago

DEADLINE

in over 1 year
NAICS: 54171
Federal
Defense Innovation Unit Commercial Solutions Opening
Solicitation # HQ0845-20-S-C001
The Defense Innovation Unit (DIU) is utilizing a streamlined Commercial Solutions Opening (CSO) to award funding agreements to traditional and nontraditional defense contractors for prototype projects. These projects aim to enhance military effectiveness and national security through the adoption of innovative commercial technologies, processes, or business practices. Awards are executed as Other Transaction Agreements (OTAs) under the authority of 10 U.S.C. 2371b, allowing for an iterative prototyping process that includes concept demonstrations, pilots, and agile development. The procurement is administered by the DIU in coordination with the Washington Headquarters Service and the Army Contracting Command. The competitive process consists of three distinct phases: the submission of a Solution Brief in response to specific Areas of Interest (AOI), an invitation to a pitch session to demonstrate technical and business viability, and the submission of a full written proposal. Evaluation is based on the merit of the proposed concept, specifically focusing on relevance to the AOI, innovation, uniqueness, and technical feasibility. Eligible respondents must be registered in the System for Award Management (SAM), possess a DUNS number, and be determined responsible by the Agreements Officer. While the government requires a total price proposal for the prototype project, the Agreements Officer will negotiate final terms, conditions, and payments directly with the selected company, including the potential consideration of company-proposed service or user license agreements.
Defense Innovation Unit

POSTED

6 months ago

DEADLINE

N/A
NAICS: 54171
Federal
Washington Headquarters Services (WHS) Commercial Solutions Opening (CSO)
Solicitation # HQ0034259WHSCSO
The Washington Headquarters Services Acquisition Directorate, through its Emerging Capabilities and Defense Prototyping Division, is utilizing a Commercial Solutions Opening to accelerate the attainment of defense capabilities. This five-year solicitation seeks innovative commercial products, services, and technologies, including concept demonstrations, pilots, and agile development activities. The program operates by publishing specific Areas of Interest that solicit solutions from commercial entities, with a particular emphasis on engaging non-traditional defense contractors and small businesses. Awards are issued as Other Transaction agreements under authorities including 10 U.S.C. Section 3458 and 4022, meaning they are not governed by the Federal Acquisition Regulation, though they remain subject to federal law and specific non-negotiable terms. The competitive process is multi-phased, requiring the submission of unclassified solution briefs, pitches, and prototype proposals. Solution briefs are evaluated based on the solution concept and business viability, including the company's go-to-market strategy and fundraising history. Successful projects are determined by the Agreements Officer based on the achievement of key technical goals or success metrics. To be eligible for an award, companies must maintain active registration in the System for Award Management and the Wide Area Work Flow for invoicing. The government protects confidential commercial information and trade secrets under applicable federal laws and executive orders, while requiring offerors to identify any intellectual property restrictions associated with their proposed solutions.
Washington Headquarters Services

POSTED

7 months ago

DEADLINE

in over 3 years
NAICS: 54171
Federal
LPS Qubit Collaboratory (LQC)
Solicitation # W911NF21S0009
The LPS Qubit Collaboratory (LQC), a partnership between the U.S. Army Research Office and the NSA's Laboratory for Physical Sciences, is soliciting research proposals to advance disruptive fundamental research in quantum information science and technology. The program focuses on qubit development for quantum computing and sensing, aiming to solve long-term challenges in qubit device physics, such as material selection, gate fidelity, and the operation of superconducting qubits. The LQC operates as a center without walls, fostering collaborative partnerships between academia, industry, FFRDCs, and government laboratories to build a future quantum workforce and create pathways for technology transition. Proposals are accepted in three categories: Incubator opportunities for single investigators or small groups to develop concepts; Collaboratory proposals for multi-sector teams to pursue proof-of-concept experiments over one to three years; and QuaCR Research Fellowships for U.S. citizen graduate and postdoctoral researchers. Eligible applicants include domestic and foreign institutions of higher education, nonprofits, and for-profit businesses. Awards are evaluated based on scientific and technical merit, potential contribution to quantum computing feasibility, investigator qualifications, and cost reasonableness. The current response deadline for submissions is April 30, 2027.
W6QK Acc-Apg Durham

POSTED

7 months ago

DEADLINE

in 6 months
NAICS: 54171
Federal
AFRL/RX Functional Materials Open BAA
Solicitation # FA8650-22-S-5002
The Air Force Research Laboratory Materials and Manufacturing Directorate is soliciting white papers and full proposals under Broad Agency Announcement FA8650-22-S-5002 to advance functional materials technologies. The program focuses on the full maturity spectrum from scientific discovery through transition into components and systems, with specific interests in Photonic Materials, including Optical Materials and Processes and Hardened Materials and Processing. The objective is to exploit innovative materials from academia, defense, and commercial sectors to enhance warfighting capabilities, specifically improving size, weight, and power characteristics. Total program funding is approximately 500 million dollars, with individual contract awards capped at 75 million dollars. The solicitation utilizes a two-step process requiring an initial white paper followed by a technical and cost proposal for selected offerors. Awards are anticipated to be Cost Plus Fixed Fee contracts with periods of performance ranging from 12 to 72 months. Evaluation is based on peer or scientific review, agency importance, and funding availability, with technical merit as the primary priority. Due to the sensitive nature of the research, strict security requirements are in place, including a Security Risk Review to mitigate foreign influence, adherence to the AFRL Wright Research Site Security Requirements, and potential Secret level safeguarding as specified in DD Form 254. Deliverables include scientific and technical reports, proof-of-concepts, and prototype hardware or software.
FA8650 USAF Afmc Afrl Pzl Afrl/pzl

POSTED

8 months ago

DEADLINE

in about 2 years

General Info

Contract Value

$355,000

NAICS

54171

Place of Performance

MD

Set-Aside

SBA

Award Issued Date

Documents

2

NCI SBIR FY24 Innovative Concept Award Program Solicitation 75N91023R00034

PDF, High priority: read this firstrfp
High

NCI SBIR FY24 Phase I Concept Award Technical Proposal Form

PDF, High priority: read this firsttechnical-proposal
High

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Timeline

PhaseClosed
Posted

Presolicitation

Type Changed

Presolicitation → Solicitation

Response Deadline

Deadline has passed

Submission Closed

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → NIH Nci
Contacts2 people available
OfficeBethesda, MD, 20892, USA
Office AddressBethesda, MD, 20892, USA
Contacts

Full Description

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The National Cancer Institute is soliciting proposals from small business concerns to perform key activities to demonstrate technical feasibility and proof-of-concept for the development of highly innovative and potentially transformative technologies in the following areas: Development of therapeutic technologies for treatment or prevention of Pediatric Cancers and/or Rare Cancers. Development of devices or diagnostic technologies for treatment, detection, and diagnosis of Pediatric Cancers and/or Rare Cancers. For this solicitation rare cancers with a 5-year survival rate of less than 50 % are encouraged and rare cancers would be defined as including all the cancers listed by the NIH Genetics and Rare Diseases Information Center. The list can be found here: https://rarediseases.info.nih.gov/diseases/diseases-by-category/1/rare-cancers. Access the NCI Surveillance, Epidemiology, and End Results Program (SEER) database (https://seer.cancer.gov/) for more information regarding 5-year cancer survival rates. Preliminary data is not required; however, the ideas should have sound scientific premise either based on the offeror's own research or literature evidence. Proposals will need to identify an anticipated product that will be developed and clearly lay out the anticipated development path. Proposals will need to clearly identify the clinical problem and cancer type(s) that the proposal will focus on with adequate justification. In addition, the offerors should propose experiments to obtain initial de-risking and proof-of-concept data. Awards will also include requirements to enhance entrepreneurship skills and to develop or refine a business model and commercialization plan. This solicitation is a Concept Award program that could serve as a pipeline for the federal Small Business Innovation Research (SBIR) program. Background for the SBIR program can be found in the Small Business Administration's policy directive found here: https://www.sbir.gov/sites/default/files/SBA_SBIR_STTR_POLICY_DIRECTIVE_OCT_2020_v2.pdf The RFP is anticipated to result in approximately 5-10 awards. NCI will make awards to the offerors based on the following considerations: Technical Evaluation; Areas of high program relevance; Program balance (i.e., balance among areas of research); Availability of funds; and, Cost/Price reasonableness. Awards are anticipated in February 2024. Awards are anticipated to be Firm Fixed Price (FFP). The duration of the contract(s) is anticipated to be twelve (12) months with a budget up to $300,000. This advertisement does not commit the United States Federal Government to award any contract. The NAICS code for this acquisition is 54171, Research and Development in the Physical, Engineering, and Life Sciences with a size standard of 500 employees.

More opportunities from Department Of Health And Human Services → NIH Nci

Same awarding agency

NAICS: 622110
Federal
NCI 2026 Cervical Cancer Screening Follow-Up
Solicitation # NCI-SBSS-DCEG-TDRP-0001
The National Cancer Institute (NCI) has issued a Small Business Sources Sought notice, NCI-SBSS-DCEG-TDRP-0001, to identify qualified small business sources for the 2026 Cervical Cancer Screening Follow-Up project. The primary objective is to obtain de-identified clinical and risk factor history and follow-up data for women previously enrolled in cervical cancer screening studies at Kaiser Permanente Northern California. This data, which includes HPV and cytology-based testing, colposcopy, biopsy, and treatment procedures, will be used to generate long-term risk estimates. The acquisition falls under NAICS code 622110 for General Medical and Surgical Hospitals, with a size standard of 47 million dollars. The anticipated period of performance is five years, spanning from January 25, 2027, to January 24, 2032, consisting of a 12-month base year and four 12-month option years. The selected contractor will be required to deliver five annual data sets in .txt, SAS, or EXCEL formats via NCI-approved secure encrypted methods, ensuring compliance with Section 508 ICT accessibility requirements. Additionally, the contractor must participate in quarterly WebEx meetings to review progress. Interested small businesses, including HUBZone, veteran-owned, 8(a), and woman-owned concerns, must submit a tailored capability statement of no more than five pages to the designated contracting officers by 8:00 AM Eastern Time on October 26, 2026.
General Medical and Surgical Hospitals

POSTED

13 days ago

DEADLINE

in 5 days
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