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Non-Optical Methods for High Speed Protein Control

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DARPA-SN-26-89Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

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The Defense Advanced Research Projects Agency Biological Technologies Office is utilizing the Expedited Research Innovation System marketplace to identify innovative, awardable solutions for a new class of rapidly switchable, non-optogenetic protein domains. The goal is to develop bio-compatible, modular protein domains for real-time cellular control that are regulated by massless, non-optical external signals, such as magnetic fields or focused ultrasound. To be considered, solutions must demonstrate activation and deactivation kinetics of 2 seconds or less, maintain robust performance for at least 300 repetitions within a living cell, and function in both split-protein and allosteric configurations. Proposals focusing on existing chemical or light-based optogenetic systems are explicitly excluded from this scope. This shopping notice is open from June 8, 2026, to December 31, 2026, with solutions reviewed on a rolling basis. Anticipated awards will have a 12-month period of performance. Evaluation is based on standard ERIS criteria, with specific emphasis on the provider's understanding of the current state of the art, technical innovation in protein engineering, team expertise in biophysics and synthetic biology, and the potential for the tool to impact biomanufacturing, biosensing, and cell-based therapeutics. Interested parties must submit their solutions via the ERIS portal as video submissions or flag existing awardable solutions via email to the designated point of contact.

General Info

DARPA seeks non-optogenetic, rapidly switchable protein domains for real-time cellular control via ERIS.

Agency

Department Of Defense → Defense Advanced Research Projects Agcy

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

VA

Set-Aside

NONE

Documents

2

DARPA-SN-26-89 Amendment 01 to Special Notice

PDF, High priority: read this firstamendment
High

DARPA-SN-26-89 Notice of Intent to Review Marketplace Solutions

PDF, High priority: read this firstshopping-notice
High

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Timeline

2 updates
Posted

special-notice

Notice updated

Response deadline changed from Dec 8, 2026 to Dec 31, 2026. The notice description changed.

Notice updated

Response deadline changed from Dec 31, 2026 to Jan 1, 2027. The point of contact changed.

Response Deadline

Submission deadline

Response Deadline

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Organization & Contact Information

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AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy
Contacts1 person available
OfficeARLINGTON, VA, 222032114, USA
Organization / AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy
Office AddressARLINGTON, VA, 222032114, USA
Contacts
Dr. Matthew Pava DARPA/BTO
contact@example.gov

Full Description

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UPDATE: The purpose of Amendment 1 to DARPA-SN-26-89, the Non-Optical Methods for High Speed Protein Control Special Notice (SN), is to clarify the notice deadline.

DARPA BTO will be actively “shopping” the ERIS Marketplace for innovative, post-competitive, awardable solutions that address the need for a new class of rapidly switchable, non-optogenetic protein domains for real-time cellular control. This effort seeks to develop a robust and versatile molecular tool for massless information transfer across a cell membrane, intended to supplement existing synthetic biology platforms.

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