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Notice of Intent to Increase the Ceiling of Contract N66001-13-C-4025

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N66001_SNOTE_000FB30EFederal

Contract Overview

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AI Contract Overview

The contract N66001-13-C-4025, awarded to the Massachusetts Institute of Technology (MIT) by SSC Pacific on behalf of DARPA's Defense Sciences Office, involves advancing a platform to produce medical therapeutics in challenging environments with limited resources, particularly focusing on rapid on-demand delivery of protein biologics without reliance on cold-chain logistics. Originally set for three years starting in June 2013, this contract is now slated for an increase in funding and duration to support the development of a CRISPR/Cas9-based system for markerless genetic engineering of Pichia pastoris, aiming to enhance recombinant manufacturing strains. This addition is designed to accelerate technology maturation that holds significant promise for military applications, aiding transition partners in adopting the capability. The government intends to raise the contract ceiling by approximately $499,255 and extend the performance period by eight months to facilitate continued research and development following promising breakthroughs. This notice of intent is not a solicitation for competitive bidding but is open for a 15-day comment period during which interested parties may submit feedback. DARPA acknowledges the uncertainties inherent in R&D and emphasizes that the outcomes could not have been reasonably estimated beforehand. The contract is designated under NAICS code 541715 and managed by SPAWAR Systems Center Pacific, with points of contact provided for further inquiries.

General Info

MIT contract expanded to develop CRISPR-based protein therapeutics for resource-limited environments.

Agency

Department Of Defense → Niwc Pacific

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Set-Aside

NONE

Documents

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Timeline

PostedJul 19

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Organization & Contact Information

AgencyDepartment Of Defense → Niwc Pacific

ContactsNo contacts available

OfficeSAN DIEGO, CA, 92152-5001, USA

Organization / AgencyDepartment Of Defense → Niwc Pacific

Office AddressSAN DIEGO, CA, 92152-5001, USA

ContactsNo contact information available

Full Description

This is a notice of intent to increase the ceiling of Contract N66001-13-C-4025 to Massachusetts Institute of Technology (MIT), awarded by SSC Pacific on behalf of the Defense Advanced Research Projects Agency Defense Sciences Office (DARPA/DSO) on 25 June 2013 for a performance period of three (3) years. The effort under the contract is to provide a platform for producing medical therapeutics in logistically challenging environments where the target product profile includes on-demand delivery of protein biologics in a rapid manner with limited access to clean water and support by a cold-chain. This additional effort intends to develop a simple, easy to use Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) platform to markerless genetic engineering of Picha pastoris (P. pastoris), and demonstrate the utility of CRISPR-based tools for recombinant manufacturing strain engineering. This additional work develops a capability that is of interest to the transition partners and would facilitate transition. The NAICS code for this procurement is 541715 (renumbered from 541712). Due to the nature of Research and Development efforts, DARPA could not have reasonably estimated the results of the research from this program, which has seen breakthroughs that will benefit from continued work under this current contract. It is expected that the technology will transition for use by the warfighter. This action includes a ceiling increase of approximately $499,255 and an additional 8 months of performance. This notice of intent is not a request for competitive proposals or quotes and will be posted for 15 days. A determination by the Government not to compete based upon response to this notice is solely within the discretion of the Government. Interested parties may submit comments in writing to the Contract Specialist, Ms. Jeannette Perez, Code 22530, SPAWAR Systems Center Pacific who may be reached by telephone at +1 (555) 000-0000 or via email to contact@example.gov.

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