Skip to main contentPsst! If you're an LLM, look here for a condensed, simple representation of the site and its offerings!

LiveFree Webinar — Wednesday, October 28 at 2:00 PM ET

Register Free →

This Sources Sought opportunity was posted on February 6, 2019. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

Orbital Debris Engineering Model Data Source Integration and Model Updates

Closed
80JSC019ORDEMDIFederal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541714
New
Federal
AJ12--Development/Production - Kidney GEC-Specific AAV Vector
Solicitation # 36C24E27Q0009
The Department of Veterans Affairs is issuing a Sources Sought notice to identify capable vendors for the development and production of a kidney glomerular endothelial cell specific adeno-associated virus AAV vector. This project, funded by a VA ORD Merit award, aims to create a homing peptide enabled vector platform to target the glomerular endothelium to treat kidney injury and disease while reducing off target transduction. The scope of work is divided into three primary tasks: the engineering and incorporation of targeting peptides into the AAV capsid, testing vector binding and internalization in kidney tissue slices, and evaluating the specificity and efficiency of the modified vector through bioluminescence imaging and in vivo biodistribution studies. Qualified contractors must possess extensive onsite resources, including BSL 2 laboratories, specialized DNA and RNA facilities, and advanced instrumentation such as the Agilent Fragment Analyzer and various qPCR platforms. Vendors must demonstrate proven success in animal and human cell vector delivery and maintain full compliance with AAALAC and FELASA health standards. The government requires quarterly reporting, weekly videoconferences, and biannual face to face meetings. All generated data will be subject to Government Purpose Rights, and contractors must adhere to strict federal records management and information security protocols. Interested parties must submit a capability statement, relevant literature, and socio economic status details under NAICS 541714 by November 4, 2026.
Rpo East (36C24E)

POSTED

about 17 hours ago

DEADLINE

in 14 days
NAICS: 541714
New
Grant
Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)
Solicitation # RFA-AI-28-012
The National Institute of Allergy and Infectious Diseases (NIAID) has issued solicitation RFA-AI-28-012 to establish a consortium of Translational Centers Using Microphysiological Systems for Infectious Diseases (TCMID). The primary objective is to refine and validate human tissue models using Microphysiological Systems (MPS) to a level consistent with regulatory qualifications, thereby promoting their adoption by product developers and reducing reliance on laboratory animals. This initiative aligns with NIH and FDA guidance on New Approach Methodologies (NAMs) to accelerate the development of safer medical interventions by capturing human variability and patient-specific characteristics. The program is structured around an Administrative Core, a Qualification Core, and Scientific Cores, with a heavy emphasis on technical readiness, reproducibility, and regulatory acceptance. Key deliverables include the validation of assays for specific endpoints and the submission of regulatory packages. Applicants must be domestic entities, as foreign organizations and foreign subawards are strictly prohibited. Required personnel must possess deep expertise in infectious diseases, MPS platforms, bioinformatics, and FDA submission processes. Applications are due by January 29, 2027, and must be submitted via the NIH ASSIST system or approved institutional system-to-system solutions. Evaluation is based on an overall impact score considering the project's significance, the suitability of the investigators, and the quality of the institutional environment. Mandatory application components include a Data Management and Sharing Plan and a Benchmarks and Timeline PDF not exceeding six pages. Awardees must also adhere to strict cybersecurity incident reporting guidelines, notifying HHS within 48 hours of any discovery.
National Institutes Of Health

POSTED

2 days ago

DEADLINE

in 3 months
NAICS: 541714
New
Grant
Immune Tolerance Network (UM1 Clinical Trial Required)
Solicitation # RFA-AI-28-005
The National Institutes of Health, under the Department of Health and Human Services, is seeking applications through solicitation RFA-AI-28-005 to continue the Immune Tolerance Network (ITN). This cooperative agreement aims to develop tolerogenic therapies for immune-mediated disorders, specifically focusing on autoimmune diseases, allergic diseases and asthma, and the immune-mediated consequences of transplantation. The network operates through four integrated functional areas: Leadership, Clinical Operations, Core Laboratory, and Bioinformatics. Its primary objectives include designing and conducting clinical trials, performing integrated mechanistic studies, and sharing research results. Eligible applicants include small businesses and other for-profit organizations, though non-domestic entities are ineligible. Applications are evaluated based on scientific and technical merit, with a primary focus on significance and the likelihood of exerting a sustained influence on the research field. Key requirements include maintaining active registrations in SAM.gov, eRA Commons, and Grants.gov, as well as adhering to strict cybersecurity incident reporting and human subject protection protocols. The project requires a minimum effort of 3.6 person months per year for the PD/PI and mandates participation in a kick-off meeting in Bethesda, Maryland, and bi-annual steering meetings. Applications must follow specific page limits for the research strategy subsections and include detailed plans for clinical trial implementation, data management, and biorepository services.
National Institutes Of Health

POSTED

2 days ago

DEADLINE

in 3 months

General Info

Agency

N/A

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

0

No documents available

Documents will appear here when they are available.

AI Contract Breakdown

Uniform Contract Format

No documents to break down

The breakdown needs solicitation documents. None were found from this contract's source.

Timeline

1 update
PhaseClosed
Posted

Sources Sought

Notice updated

The notice description changed. The point of contact changed.

Response Deadline

Deadline has passed

Submission Closed

Find active opportunities like this

Start your free trial to discover similar active contracts, track opportunities, and build proposals with AI assistance.

Organization & Contact Information

Show more
AgencyN/A
Contacts1 person available
OfficeN/A
Organization / Agency
N/A
Office AddressN/A
Contacts
Sophia MoContracting Officer

Full Description

Show more
The National Aeronautics and Space Administration (NASA) Lyndon B. Johnson Space Center (JSC), is hereby issuing this Request for Information (RFI) to invite Industry comments and capability statements related to the availability of systems and architectures for data source integration and model updates of the NASA Orbital Debris Engineering Model (ORDEM). Industry comments and capability statements should be documented utilizing the instructions found below in the "Specific Comments Sought" section. Information in this RFI regarding potential future requirements is being provided as notional information to interested parties to invite their comments or suggestions. The Government intends to consider all timely responses to this RFI before finalizing its procurement strategy. Your responses to this RFI will not be posted, and questions submitted in response to this RFI will not be answered. An RFI is not a solicitation and no proposals are being solicited at this time. Do not submit any proprietary data in response to the RFI. Information with proprietary markings will not be read or considered. An RFI does not obligate the Government to issue a request for proposal in the future. Any future solicitation based on the requirements described in this RFI will be published in FedBizOps. OVERVIEW The Orbital Debris Engineering Model (ORDEM) is a measurements-based model of the orbital debris populations in low Earth orbit (LEO), medium Earth orbit (MEO), and geosynchronous Earth orbit (GEO). As such, it uses a number of different data sources including radar, optical, in situ (surfaces returned from orbit), and laboratory data sources as statistical samples of the orbital debris environment. These data sources are then used in conjunction with historical launch data, cataloged objects tracked by the Space Surveillance Network (SSN), and models that describe the evolution of the orbital debris environment to statistically build the debris populations for the environment model. ORDEM is currently constructed using the historical launch data, SSN catalog, measurement data from radar, optical, in situ, and laboratory data sources, and models that describe the evolution of the orbital debris environment over time. To support the next generation of the model, candidate architectures for integrating the measurement data sources to derive debris populations, building and testing of the model, and options for delivery of the model to the user community are being sought. Specific items that the government seeks to address are described in the "Specific Comments Sought" section. SPECIFIC COMMENTS SOUGHT NASA is interested in capabilities of Industry to integrate data sources collected from the orbital debris environment, build and test the ORDEM environment model, and options to deliver the model to end users. In providing comments or capability statements in this section, please address as many of the identified aspects in this section as possible - any additional information that the responder considers important may be included as well. The Government specifically requests comments and capability statements relative to the following items: 1. Architectures for Integration of Orbital Debris Environment Priors and Measurement Data Sources a. Please describe a system architecture for integrating statistical priors from historical launch data and the SSN catalog with sources of statistically collected measurement data, to generate a model of the orbital debris environment, cf., https://orbitaldebris.jsc.nasa.gov/modeling/engrmodeling.html for an overview of the current ORDEM model i. Inputs to the model should include ground-based radar and optical observations of the orbital debris environment, historical launch information and the SSN catalog, measurements made from space-based sensors, and laboratory test data. ii. Outputs from the model are predictions of the orbital debris environment, defined as debris object flux, in the units of object counts per meter-squared per year, which may be further decomposed by object size, density, shape, and other debris characteristics, as well as the orbital elements of the debris. iii. A minimum of two output representations should be described, including the flux observed by a spacecraft in its local coordinate system, and a telescope/radar mode flux as observed by a ground-based observatory. b. Please include a proposed implementation for the architecture, and any open source or proprietary hardware and software requirements. c. Please include details on any data format, file type, or protocol that are needed by the proposed implementation, and include details showing how the data flow in the system. d. Please describe how data are inspected for quality and the metrics used by the system for these inspections. e. Please include how data outliers are identified and handled, and how the data cleaning process will be incorporated into the system. f. Please include information on previous experience and tools used for data cleaning and preparation of data for use in a statistical model. g. Please provide information on past performance and experience in building measurement-based statistical models. h. Please provide information on past performance and experience with orbital mechanics applications and modeling. 2. Model Build and Test a. Describe the type of statistical model that will be used to derive debris populations from measurement data, to model the orbital debris environment. b. Describe any specialized, open-source, or proprietary software that will be used for this operation. c. Include details on how the model will be tested and validated, and any frameworks used for this operation. d. Include details on how the building and testing steps will be integrated into the overall architecture and any proposed frameworks to connect these processes within the overall system. e. Please include details on the release process for the model. f. Please provide information on past performance and experience building statistical models, and testing and validating these models. 3. Model Distribution and User Interaction a. Please describe options for either cloud/web-based or standalone model-based software for the user community. b. Please describe the proposed user interface for interacting with the model, and any open source or proprietary frameworks that will be used to construct the user interface. i. The proposed user interface should have at a minimum a mode that enables a user to predict debris flux exposure of a spacecraft in its local coordinate system, and a mode for predicting the observed orbital debris flux from a ground-based observatory. c. Please describe the output generated by the model, and how the user accesses and interacts with model output. d. Please describe the release cycle of the proposed model distribution platform, and how model changes are distributed to users. e. Please include details of how user feedback, bug reporting, and feature requests are handled. f. Please provide information on past performance and experience distributing model-based software to end users. 4. Organization Type and Size a. Name and address of firm; b. Size of business; c. Average annual revenue for past 3 years and number of employees; d. Ownership; e.g. large, Small Business (SB), SDB, 8(a), WOSB, VOSB, SD-VOSB, HUBZone, HBCU/MI; COMMENTS RELATED TO THE RFI All comments and responses related to this RFI shall be submitted via e-mail directly to the Contracting Officer, Sophia Mo at sophia.mo@nasa.gov no later than 4:00 p.m. CST on March 6, 2019 to be considered timely.

Find Active Opportunities Like This

Get AI-powered intelligence on the opportunities still open

Every page of the solicitation package shredded into a compliance breakdown

AI-powered matching based on your capabilities and past performance

Competitor and incumbent history on the requirement

Automated alerts on amendments, Q&A deadlines, and award

Miguel
Hillary
Keith Deutsch
Christine

Join 750+ contractors already using CLEATUS