Rapid Comprehensive Diagnostic Test for Multi-System Autoimmune Disease

This contract seeks the development of innovative, rapid diagnostic assays aimed at addressing the critical need for early and accurate detection of multi-system autoimmune diseases. The intended diagnostic tool would enable primary care physicians to identify and predict tissue-specific manifestations of autoimmune conditions, improving patient management by facilitating timely specialist referrals. This approach leverages recent advancements in technology that allow for the detection of immune-mediated tissue stress through analysis of circulating cells and tissue-specific molecular markers. The solicitation is a total small business set-aside under the Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) mandate, targeting companies with fewer than 500 employees. Issued by the Department of Health and Human Services through the ARPA-H agency, the contract emphasizes accelerating translational technologies that can be implemented in primary care settings. Responses to the solicitation are due by July 10, 2026, and interested parties are encouraged to explore the detailed requirements and submission guidelines on the official SBIR portal.