This Sources Sought opportunity from Department Of Health And Human Services was posted on April 1, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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RFI/SSN for Host Directed Therapeutics for the Prevention of Progression to ARDS

Closed

RPP-26-12-PreventARDS_RFI_SSNFederal

Submission Closed04/15/2026, 07:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541714

New

Federal

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AJ12--Development/Production - Kidney GEC-Specific AAV Vector

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Immune Tolerance Network (UM1 Clinical Trial Required)

Solicitation # RFA-AI-28-005

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Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)

Solicitation # RFA-AI-28-012

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Solicitation # 75N93027R00003

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Alternative Protein Technologies for Military Field Feeding

Solicitation # W911QY27ALTPROTEINS

The US Army Combat Capabilities Development Command Soldier Center is seeking information from Massachusetts-based offerors to identify innovative alternative protein technologies for integration into military rations. The objective is to enhance food supply chain resilience and provide nutrient-dense, lightweight food options for warfighters. Areas of interest include fermentation and biomanufacturing processes, innovative product development for shelf-stable rations, consumer research for military acceptability, and the optional provision of GRAS-certified food samples. Specifically, the government is excluding any solutions involving cell-cultured, lab-grown meat, or insect proteins, focusing instead on technologies between TRL 4 and 6. This is a Sources Sought Announcement for market research purposes and not a formal solicitation or a promise of future funding. Interested parties must submit a BAA preproposal by November 23, 2026, including a technical approach, past performance, and a rough order of magnitude cost estimate. Submissions must be sent via email to the designated points of contact and include the offeror's business size, NAICS code, and CAGE code to verify their Massachusetts location.

W6QK Acc-Apg Natick

POSTED

2 days ago

DEADLINE

in about 1 month

General Info

Agency

Department Of Health And Human Services → Barda - Aspr / Daappo / Barda Dcma

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Washington, DC, 20024, USA

Set-Aside

NONE

Documents

BARDA RPP-26-12 Host-Directed Therapeutics for ARDS Prevention

rpp

High

RFI Sources Sought Notice for Host Directed Therapeutics to Prevent ARDS Progression

rfi

High

RPP-26-12 Prevent ARDS RFI Attachment A Vendor Questions

rfi

Low

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseClosed

PostedApr 1

Sources Sought

Response DeadlineApr 15

Deadline has passed

Submission Closed

04/15/2026, 07:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → Barda - Aspr / Daappo / Barda Dcma

Contacts1 person available

OfficeWASHINGTON, DC, 20515, USA

Organization / AgencyDepartment Of Health And Human Services → Barda - Aspr / Daappo / Barda Dcma

Office AddressWASHINGTON, DC, 20515, USA

Contacts

Laura Saddison

contact@example.gov

Full Description

Objective

The objective of this combined Request for Information (RFI) / Sources Sought Notice (SSN) is for BARDA program officials to better refine the requirements for host directed therapeutics for the prevention of progression to acute respiratory distress syndrome (ARDS) in support of BARDA’s Influenza and Emerging Infectious Diseases Division (IEIDD). BARDA is considering establishing long-term partnerships with multiple contractors. The information requested from this RFI will serve as market research while also assisting with requirements development of this vital program. None of the information in this RFI is intended to suggest a particular approach or contract solution.

Project Scope

BARDA seeks Performer(s) to support the continuation of the ARDS Preparedness and Response Program. This project supports advancing the late-stage clinical development of host-directed therapeutics for the prevention of progression to ARDS in hospitalized patients with viral respiratory infection who require supplemental oxygen. The Proposal would include a Phase 3 clinical development plan including dose selection for a host-directed therapeutic product that has supportive Phase 2 data demonstrating efficacy in preventing worsening of severe disease in hospitalized patients with viral respiratory infection. A product that is in an ongoing Phase 3 trial is preferred. 

**Please see Attachment B – Draft RPP for detailed information.

SAM.Gov Sources Sought Notice (SSN)

This RFI also constitutes as a Sources Sought Notice. BARDA anticipates awards will be made to multiple contractors with the best solutions and capabilities.

Mandatory Eligibility Criteria: Proposed host-directed therapeutic(s) must meet the following minimum criteria to be considered for award: 

Data demonstrating a robust therapeutic mechanism of action that is applicable to the resolution of severe disease due to influenza infection. 
Demonstrated preclinical and/or clinical efficacy against severe disease due to viral respiratory infection. 
Relevance to viral respiratory infection, including influenza, through intended enrollment of appropriate patients. 
Rationale behind dose selection for a Phase 3 study. 
Feedback and concurrence from FDA on the study design of a proposed or current Phase 3 study.

Note: Failure to adequately document compliance of the above mandatory requirement will result in the elimination of the Offeror from further consideration. No further discussions will be held.

BARDA encourages qualified contractors to respond so we can better understand the current state of the science.

This SSN/RFI is issued for information and planning purposes only and does not constitute a solicitation. All information received in response to the SSN/RFI that is marked as proprietary will be handled accordingly by the Government. Responses to this SSN/RFI are not considered offers and cannot be accepted by BARDA to form a binding contract. Responders are solely responsible for all expenses associated with responding to this SSN/RFI. All information submitted in response to this SSN/RFI shall remain with the Government and will not be returned.

*BARDA may compete the resulting RPP amongst eligible respondents of this RFI only.

RFI Response Format:

Interested parties are invited to submit responses to any of the questions in Attachment A as well as a technical capabilities statement. Responses to this RFI should explore the listed questions as well as similar issues to best support the successful advancement of this effort. Responses should consist of a cover page that provides administrative and contact information (contact name, title, email address, phone number) and organizational information of the responder (entity name, headquarters, mailing address). Respondents are also invited to review the draft RPP included as Attachment B and provide general feedback via track changes. Respondents are requested to provide:

Responses to questions in Attachment A – RFI Questions
Technical Capabilities Statement
General Feedback on Attachment B – Draft RPP via track changes

Respondents must clearly mark all copyrighted information, data, and materials with appropriate restrictive legends (e.g., confidential, privileged, proprietary, trade secret). To aid in protecting your information, please segregate proprietary information. DO NOT SUBMIT ANY CLASSIFIED INFORMATION.

Responses to this RFI should explore the listed questions as well as similar issues to best support the successful advancement of this effort.

Please submit responses by email to laura.saddison@hhs.gov no later than 3:00 pm EDT April 15, 2026.

Responses:

BARDA encourages qualified performers to respond so we can better understand the current state of the science.

The full draft RPP is being provided to allow for advance planning purposes and to allow additional time for potential proposal development and/or partnering.

Please note that non-federal employees performing advisory and assistance services will have access to any submission under this RFI. All non-federal employees are required to sign a non-disclosure agreement prior to accessing the RFI responses.

Thank you for your participation in this RFI. Please contact laura.saddison@hhs.gov with any questions or concerns.