Strategic Marburg Advanced Research and Development, Preparedness, Registration, Evaluation and Procurement (SMART-PREP)

The Strategic Marburg Advanced Research and Development, Preparedness, Registration, and Procurement (SMART-PREP) contract, awarded under solicitation number 75A50126C00001, authorizes BARDA to utilize Project BioShield funds to advance the development, regulatory approval, procurement, and logistics of a monovalent Marburg virus vaccine. The scope includes funding for clinical development stages, FDA licensure activities, procurement of the finished product, transportation, and the implementation of vendor-managed inventory systems to ensure rapid deployment readiness. The contract employs a hybrid cost-reimbursement and fixed-price structure due to uncertainties in requirements that preclude a purely fixed-price arrangement, allowing flexibility to adapt as technical and regulatory pathways evolve. The contract is managed by BARDA within the Office of the Assistant Secretary for Preparedness and Response under the U.S. Department of Health and Human Services, with performance taking place in Washington, D.C. The North American Industry Classification System code 541714 identifies the focus on research and development in biotechnology. No set-aside provisions apply, making it open to all eligible vendors. Primary point of contact is Yifan Yang, with Greg Smith as secondary contact, both reachable via HHS email addresses. The contract was officially posted on May 7, 2026, and can be accessed through the SAM.gov platform for further details.